SH3YL1 - SH3 and SYLF domain containing 1 Gene

Homo sapiens

Also known as RAY

Gene ID: 26751 | Gene type: protein coding

About SH3YL1

Cytogenetic location: 2p25.3 Genomic coordinates (GRCh38): 2:218,136-264,824 (from NCBI)

This gene has 29 transcripts (splice variants) and 200 orthologues. Ubiquitous expression in kidney (RPKM 16.8), thyroid (RPKM 9.9) and 24 other tissues.

Summary

Enables Phosphatase binding activity and phosphatidylinositol binding activity. Predicted to act upstream of or within phosphatidylinositol biosynthetic process and regulation of ruffle assembly. Located in ruffle membrane. [provided by Alliance of Genome Resources, Apr 2022]

SH3YL1 Products(4)

mRNA	Protein	Name
NM_001159597.3	NP_001153069.1	SH3 domain-containing YSC84-like protein 1 isoform 2
NM_001282682.2	NP_001269611.1	SH3 domain-containing YSC84-like protein 1 isoform 3
NM_001282687.2	NP_001269616.1	SH3 domain-containing YSC84-like protein 1 isoform 4
NM_015677.4	NP_056492.2	SH3 domain-containing YSC84-like protein 1 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables phosphatase binding	IDA IDA: Inferred from direct assay	21624956	GOA
enables phosphatidylinositol binding	IDA IDA: Inferred from direct assay	21624956	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in ruffle membrane	IDA IDA: Inferred from direct assay	21624956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SH3YL1 Protein Structure

Ysc84

SH3_9

0
100
200
300
342 a.a.

Protein Preferred Names

Protein Names

SH3 domain-containing YSC84-like protein 1

SH3 domain containing, Ysc84-like 1

SH3YL1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SH3YL1	Q96HL8	SH3D19	Homo sapiens	Q5HYK7-2	Y2H Array	32296183
Intra	SH3YL1	Q96HL8	SH3D19	Homo sapiens	Q5HYK7-2	Y2H Prey Pooling	32296183
Intra	SH3YL1	Q96HL8	SH3D19	Homo sapiens	Q5HYK7-2	Anti Tag CoIP	28514442
Intra	SH3YL1	Q96HL8	SH3D19	Homo sapiens	Q5HYK7	Y2H Array	25416956
Intra	SH3YL1	Q96HL8	SH3D19	Homo sapiens	Q5HYK7	Anti Tag CoIP	33961781
Intra	SH3YL1	Q96HL8	VPS37B	Homo sapiens	Q9H9H4	Validated Y2H	32296183
Intra	SH3YL1	Q96HL8	VPS37B	Homo sapiens	Q9H9H4	Y2H Array	25416956
Intra	SH3YL1	Q96HL8	VPS37B	Homo sapiens	Q9H9H4	Y2H Array	32296183
Intra	SH3YL1	Q96HL8	VPS37B	Homo sapiens	Q9H9H4	Y2H	21516116
Intra	SH3YL1	Q96HL8	VPS37B	Homo sapiens	Q9H9H4	Y2H Prey Pooling	32296183
Intra	SH3YL1	Q96HL8	ZBTB7B	Homo sapiens	O15156	Validated Y2H	25416956
Intra	SH3YL1	Q96HL8	ZBTB7B	Homo sapiens	O15156	Y2H Array	25416956
Intra	SH3YL1	Q96HL8	ZBTB7B	Homo sapiens	O15156	Y2H Prey Pooling	25416956
Intra	SH3YL1	Q96HL8	GFAP	Homo sapiens	P14136	Y2H Prey Pooling	25416956
Intra	SH3YL1	Q96HL8	GFAP	Homo sapiens	P14136	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Meier-Gorlin Syndrome 4

MGORS4

Meier-Gorlin Syndrome, Type 4

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12849	SH3YL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SH3YL1	VGNC	VGNC:77338
Felis catus	SH3YL1	VGNC	VGNC:65117
Mus musculus	SH3YL1	MGD	MGI:1346118
Rattus norvegicus	SH3YL1	RGD	RGD:1306440
Canis familiaris	SH3YL1	VGNC	VGNC:46137
Bos taurus	SH3YL1	VGNC	VGNC:34584

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