PLEKHG4B - pleckstrin homology and RhoGEF domain containing G4B Gene

Homo sapiens

Gene ID: 153478 | Gene type: protein coding

About PLEKHG4B

This gene has 4 transcripts (splice variants), 144 orthologues and 22 paralogues. Biased expression in thyroid (RPKM 1.2), testis (RPKM 0.6) and 8 other tissues.

Summary

This gene encodes a large protein that contains a pleckstrin homology domain and may function as a guanine nucleotide exchange factor. [provided by RefSeq, May 2017]

PLEKHG4B Products(1)

mRNA	Protein	Name
NM_052909.5	NP_443141.4	pleckstrin homology domain-containing family G member 4B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables guanyl-nucleotide exchange factor activity	IDA IDA: Inferred from direct assay	32203420	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	27107012	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell-cell adhesion	IDA IDA: Inferred from direct assay	33310911	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in basal plasma membrane	IDA IDA: Inferred from direct assay	38088892	GOA
located in cell-cell junction	IDA IDA: Inferred from direct assay	33310911	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	33310911	GOA
located in nucleus	IDA IDA: Inferred from direct assay	33310911	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLEKHG4B Protein Structure

RhoGEF

0
200
400
600
800
1000
1200
1271 a.a.

Protein Preferred Names

Protein Names

pleckstrin homology domain-containing family G member 4B

PH domain-containing family G member 4B

PLEKHG4B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PLEKHG4B	Q96PX9	ARHGEF11	Homo sapiens	O15085-1	Anti Tag CoIP	32203420
Intra	PLEKHG4B	Q96PX9	FHL3	Homo sapiens	Q13643	Validated Y2H	27107012
Intra	PLEKHG4B	Q96PX9	ARHGEF12	Homo sapiens	Q9NZN5-1	Anti Tag CoIP	32203420

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Cri-Du-Chat Syndrome

5p Deletion Syndrome	5p Partial Monosomy Syndrome
Monosomy 5p	Cat Cry Syndrome
Chromosome 5p Deletion Syndrome	Cri Du Chat Syndrome
5p- Syndrome	5p Minus Syndrome
Chromosome 5p- Syndrome	Chromosome 5 Short Arm Deletion Syndrome
Chromosome 5p Deletion	Deletion 5p
Cri Du Chat	5p Partial Deletion Syndrome
Partial Deletion Of Short Arm Of Chromosome 5 Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10692	PLEKHG4B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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