2. Gene
  3. AMOT - angiomotin Gene

AMOT - angiomotin Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 154796 | Gene type: protein coding

About AMOT

Cytogenetic location: Xq23 Genomic coordinates (GRCh38): X:112,774,877-112,840,831 (from NCBI)

This gene has 5 transcripts (splice variants), 203 orthologues and 2 paralogues. Broad expression in placenta (RPKM 13.4), brain (RPKM 9.3) and 21 other tissues.

Summary

This gene belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. The encoded protein is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

AMOT Products(4)

mRNA Protein Name
NM_001113490.2 NP_001106962.1 angiomotin isoform 1
NM_001386998.1 NP_001373927.1 angiomotin isoform 1
NM_001386999.1 NP_001373928.1 angiomotin isoform 1
NM_133265.5 NP_573572.1 angiomotin isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables angiostatin binding IDA
IDA: Inferred from direct assay
11257124 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11257124 GOA
enables signaling receptor activity IDA
IDA: Inferred from direct assay
11257124 GOA
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within hippo signaling IGI
IGI: Inferred from genetic interaction
21205866 GOA
acts upstream of or within negative regulation of angiogenesis IDA
IDA: Inferred from direct assay
11257124 GOA
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
21205866 GOA
involved in negative regulation of vascular permeability IDA
IDA: Inferred from direct assay
16043488 GOA
involved in positive regulation of blood vessel endothelial cell migration IDA
IDA: Inferred from direct assay
16043488 GOA
acts upstream of or within regulation of cell migration IDA
IDA: Inferred from direct assay
11257124 GOA
Cellular Component GO Annotation Evidence Reference Source
part of COP9 signalosome IDA
IDA: Inferred from direct assay
18850735 GOA
located in actin filament IDA
IDA: Inferred from direct assay
11257124 GOA
located in bicellular tight junction IDA
IDA: Inferred from direct assay
16043488 GOA
located in cell surface IDA
IDA: Inferred from direct assay
16043488 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
16043488 GOA
located in endocytic vesicle IDA
IDA: Inferred from direct assay
11257124 GOA
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
11257124 GOA
located in lamellipodium IDA
IDA: Inferred from direct assay
11257124 GOA
located in membrane IDA
IDA: Inferred from direct assay
16043488 GOA
located in ruffle IDA
IDA: Inferred from direct assay
11257124 GOA
located in stress fiber IDA
IDA: Inferred from direct assay
16043488 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AMOT Protein Structure

Angiomotin_C

Angiomotin_C: Angiomotin C terminal (599 - 807)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1084 a.a.
Protein Preferred Names Protein Names

angiomotin

AMOT Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
AMOT Q4VCS5 NF2 Homo sapiens P35240
Anti Tag CoIP
21481793
Intra
AMOT Q4VCS5 NF2 Homo sapiens P35240
Y2H Fragment Pooling
23414517
Intra
AMOT Q4VCS5 NF2 Homo sapiens P35240
Anti Tag CoIP
24366813
Intra
AMOT Q4VCS5 NF2 Homo sapiens P35240
Anti Tag CoIP
19615732
Intra
AMOT Q4VCS5 NF2 Homo sapiens P35240
Anti Bait CoIP
21481793
Intra
AMOT Q4VCS5 ARHGAP17 Homo sapiens Q68EM7
Anti Bait CoIP
21481793
Cross
AMOT Q4VCS5 Nf2 Mus musculus P46662
Anti Tag CoIP
25026211
Intra
AMOT Q4VCS5 IKBKG Homo sapiens Q9Y6K9
Anti Bait CoIP
30561431
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Papilloma

Papillomatosis
Neurofibromatosis, Type Ii

Neurofibromatosis 2

Neurofibromatosis, Type 2

NF2

Neurofibromatosis Type Ii

Bilateral Acoustic Neurofibromatosis

Banf

Acn

Central Neurofibromatosis

Neurofibromatosis, Central Type

Acoustic Schwannomas, Bilateral

Acoustic Neurinoma, Bilateral

Bilateral Acoustic Neurinoma

Bilateral Acoustic Schwannomas

Familial Acoustic Neuromas
Sveinsson Chorioretinal Atrophy

SCRA

Atrophia Areata

Helicoid Peripapillary Chorioretinal Degeneration

Hpcd

Aa

Peripapillary Chorioretinal Degeneration, Icelandic Type

Helicoidal Peripapillary Chorioretinal Degeneration

Atrophy, Chorioretinal, Sveinsson
Meningioma, Familial

Meningioma

Familial Meningioma

Meningioma, Familial, Susceptibility To

Meningeal Neoplasm

Meningeal Neoplasms

Meningiomas

Meningioma, Nf2-Related, Somatic

Meningioma, Sis-Related

Meningothelial Cell Tumor

Neoplasm Of The Meninges

Primary Meningeal Tumor

Familial Multiple Meningioma

MNGMA

Meningioma, Benign, No Icd-O Subtype

Intracranial Meningioma

Meningothelial Cell Neoplasm

Supratentorial Meningioma

Primary Neoplasm Of Spinal Meninges

Benign Intracranial Meningioma

Benign Meningioma

Meningeal Tumours

Meningeal Sarcoma Of Unspecified Site

Meningothelial Sarcoma Of Unspecified Site
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00663 AMOT Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris AMOT VGNC VGNC:37835
Felis catus AMOT VGNC VGNC:59769
Rattus norvegicus AMOT RGD RGD:1564027
Mus musculus AMOT MGD MGI:108440
Bos taurus AMOT VGNC VGNC:25870
Macaca mulatta AMOT VGNC VGNC:69627