2. Gene
  3. Hspd1 - heat shock protein 1 (chaperonin) Gene

Hspd1 - heat shock protein 1 (chaperonin) Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as 60kDa; CPN60; Hsp60; HSP-60; HSP-65

Gene ID: 15510 | Gene type: protein coding

About Hspd1

Summary

Enables lipopolysaccharide binding activity. Involved in positive regulation of T cell activation. Acts upstream of or within T cell activation; cellular response to interleukin-7; and positive regulation of cytokine production. Located in mitochondrion; plasma membrane; and secretory granule. Is expressed in several structures, including brain; eye; and urinary system. Used to study hereditary spastic paraplegia 13. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autistic disorder; glucose intolerance; hereditary spastic paraplegia (multiple); and hypomyelinating leukodystrophy 4. Orthologous to human HSPD1 (heat shock protein family D (Hsp60) member 1). [provided by Alliance of Genome Resources, Apr 2022]

Hspd1 Products(2)

mRNA Protein Name
NM_001356512.1 NP_001343441.1 60 kDa heat shock protein, mitochondrial
NM_010477.4 NP_034607.3 60 kDa heat shock protein, mitochondrial
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables lipopolysaccharide binding IDA
IDA: Inferred from direct assay
17164250 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within T cell activation IDA
IDA: Inferred from direct assay
15371451 MGI
acts upstream of or within T cell activation IGI
IGI: Inferred from genetic interaction
17164250 MGI
NOT involved in adhesion of symbiont to host IDA
IDA: Inferred from direct assay
20633027 MGI
acts upstream of or within cellular response to interleukin-7 IDA
IDA: Inferred from direct assay
29581031 MGI
acts upstream of interferon-alpha production IDA
IDA: Inferred from direct assay
17164250 MGI
involved in positive regulation of T cell activation IDA
IDA: Inferred from direct assay
17164250 MGI
acts upstream of or within positive regulation of interferon-alpha production IDA
IDA: Inferred from direct assay
17164250 MGI
acts upstream of or within positive regulation of type II interferon production IDA
IDA: Inferred from direct assay
15371451 MGI
involved in positive regulation of type II interferon production IDA
IDA: Inferred from direct assay
17164250 MGI
acts upstream of or within positive regulation of type II interferon production IGI
IGI: Inferred from genetic interaction
17164250 MGI
acts upstream of type II interferon production IDA
IDA: Inferred from direct assay
15371451 MGI
acts upstream of type II interferon production IGI
IGI: Inferred from genetic interaction
17164250 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
21874024 MGI
located in intracellular membrane-bounded organelle IDA
IDA: Inferred from direct assay
15136728 MGI
located in membrane IMP
IMP: Inferred from mutant phenotype
20080761 MGI
located in migrasome IDA
IDA: Inferred from direct assay
34048705 MGI
is active in mitochondrion IDA
IDA: Inferred from direct assay
26644517 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
1516759 MGI
located in secretory granule IDA
IDA: Inferred from direct assay
1516759 MGI
located in sperm plasma membrane IDA
IDA: Inferred from direct assay
15252132 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

60 kDa heat shock protein, mitochondrial

60 kDa chaperonin

chaperonin 60

heat shock 60kDa protein 1 (chaperonin)

heat shock protein 60

heat shock protein, 60 kDa

mitochondrial matrix protein P1

Recombinant Hspd1 Proteins

Cat. No. Product Name Accession Purity
HY-P73916 HSP60 Protein, Mouse (His, solution) P63038 (L2-F573) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-115715 EN219 98.56% Unkown
HY-RS06447 HSPD1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hspd1 NCBI NCBI:3329