Casp12 - caspase 12 Gene

Rattus norvegicus

Gene ID: 156117 | Gene type: protein coding

About Casp12

Primary_assembly 8: 2,642,434-2,674,037 forward strand.mRatBN7.2:CM026981.1

This gene has 3 transcripts (splice variants), 273 orthologues, 12 paralogues and is associated with 31 phenotypes. Biased expression in Adrenal (RPKM 149.4), Liver (RPKM 16.3) and 8 other tissues.

Summary

Enables cysteine-type peptidase activity; endopeptidase activity; and protease binding activity. Involved in several processes, including cellular response to manganese ion; positive regulation of striated muscle cell apoptotic process; and protein autoprocessing. Located in cytosol and nucleus. Used to study sciatic neuropathy. Biomarker of several diseases, including diabetes mellitus (multiple); heart disease (multiple); neurodegenerative disease (multiple); post-traumatic stress disorder; and ureteral obstruction. Orthologous to human CASP12 (Caspase 12 (gene/pseudogene)). [provided by Alliance of Genome Resources, Apr 2022]

Casp12 Products(1)

mRNA	Protein	Name
NM_130422.1	NP_569106.1	caspase-12

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables cysteine-type peptidase activity	IDA IDA: Inferred from direct assay	18316105	RGD
enables endopeptidase activity	IDA IDA: Inferred from direct assay	18332441	RGD
enables protease binding	IDA IDA: Inferred from direct assay	18332441	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	20818395	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	29568958	RGD
involved in cellular response to manganese ion	IEP IEP: Inferred from expression pattern	23934647	RGD
involved in intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	10638761	RGD
involved in luteolysis	IEP IEP: Inferred from expression pattern	25332219	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	17083921	RGD
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	17083921	RGD
involved in positive regulation of striated muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	26801321	RGD
involved in protein autoprocessing	IDA IDA: Inferred from direct assay	18332441	RGD
involved in protein catabolic process	IDA IDA: Inferred from direct assay	18316105	RGD
involved in response to anoxia	IEP IEP: Inferred from expression pattern	17083921	RGD
involved in response to endoplasmic reticulum stress	IEP IEP: Inferred from expression pattern	16979584	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	17433554	RGD
involved in response to iron(III) ion	IEP IEP: Inferred from expression pattern	19594550	RGD
involved in response to kainic acid	IEP IEP: Inferred from expression pattern	17251432	RGD
involved in response to nicotine	IEP IEP: Inferred from expression pattern	18477628	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	16236330	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Casp12 Protein Structure

CARD_CASP1-like

CASc

0
100
200
300
420 a.a.

Protein Preferred Names

Protein Names

caspase-12

CASP-12

Casp12 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Casp12	Q920D5	RIGI	Homo sapiens	O95786	IF	20818395
Cross	Casp12	Q920D5	RIGI	Homo sapiens	O95786	Pull Down	20818395

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01945	CASP12 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01946	Casp12 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01947	Casp12 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Casp12	NCBI	NCBI:100506742

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