CYP2J2 - cytochrome P450 family 2 subfamily J member 2 Gene

Homo sapiens

Also known as CPJ2; CYPIIJ2

Gene ID: 1573 | Gene type: protein coding

About CYP2J2

Cytogenetic location: 1p32.1 Genomic coordinates (GRCh38): 1:59,893,308-59,969,212 (from NCBI)

This gene has 5 transcripts (splice variants), 151 orthologues and 15 paralogues. Biased expression in small intestine (RPKM 44.5), heart (RPKM 35.2) and 10 other tissues.

Summary

This gene encodes a member of the Cytochrome P450 superfamily of Enzymes. The Cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of Cholesterol, Steroids and Other lipids. This protein localizes to the endoplasmic reticulum and is thought to be the predominant Enzyme responsible for epoxidation of endogenous arachidonic acid in cardiac tissue. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jan 2016]

CYP2J2 Products(1)

mRNA	Protein	Name
NM_000775.4	NP_000766.2	cytochrome P450 2J2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables arachidonate 11,12-epoxygenase activity	IDA IDA: Inferred from direct assay	11901223	GOA
enables arachidonate 14,15-epoxygenase activity	IDA IDA: Inferred from direct assay	11901223	GOA
enables arachidonate epoxygenase activity	IDA IDA: Inferred from direct assay	8631948	GOA
enables isomerase activity	IDA IDA: Inferred from direct assay	19737933	GOA
enables linoleic acid epoxygenase activity	IDA IDA: Inferred from direct assay	11901223	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in epoxygenase P450 pathway	IDA IDA: Inferred from direct assay	8631948	GOA
involved in icosanoid metabolic process	IDA IDA: Inferred from direct assay	19737933	GOA
involved in linoleic acid metabolic process	IDA IDA: Inferred from direct assay	11901223	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CYP2J2 Protein Structure

p450

0
100
200
300
400
502 a.a.

Protein Preferred Names

Protein Names

cytochrome P450 2J2

albendazole monooxygenase (hydroxylating)

Related Diseases

Diseases

Alias

Atherosclerosis Susceptibility

Atherosclerosis	Atherosclerosis, Susceptibility To
ATHS	Atherogenic Lipoprotein Phenotype
Alp	Arteriosclerosis

Hemopericardium

Haemopericardium	Pericardial Effusion
Haematopericardium	Pneumohemopericardium
Pericardium Haemorrhage	Haemorrhagic Pericarditis

Cardiovascular System Disease

Abnormality Of The Cardiovascular System	Cardiovascular Disease
Disease Of Subdivision Of Hemolymphoid System	Disorder Of Cardiovascular System
Cardiovascular Diseases

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0319	Salvianolic acid C	Inhibitor	99.94%	Unkown
HY-N0515	Ophiopogonin D		99.54%	Unkown
HY-117026	LKY-047	Inhibitor	98.85%	Unkown
HY-RS03465	CYP2J2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CYP2J2	RGD	RGD:620007
Macaca mulatta	CYP2J2	VGNC	VGNC:99873
Felis catus	CYP2J2	VGNC	VGNC:103321
Canis familiaris	CYP2J2	VGNC	VGNC:50354

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