CYP4A11 - cytochrome P450 family 4 subfamily A member 11 Gene

Homo sapiens

Also known as CP4Y; CYP4A2; CYP4AII; CYPIVA11

Gene ID: 1579 | Gene type: protein coding

About CYP4A11

Cytogenetic location: 1p33 Genomic coordinates (GRCh38): 1:46,929,188-46,941,476 (from NCBI)

This gene has 8 transcripts (splice variants), 376 orthologues and 12 paralogues. Biased expression in liver (RPKM 280.4) and kidney (RPKM 130.2).

Summary

This gene encodes a member of the Cytochrome P450 superfamily of Enzymes. The Cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of Cholesterol, Steroids and Other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as laurate and myristate. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jan 2016]

CYP4A11 Products(3)

mRNA	Protein	Name
NM_000778.4	NP_000769.2	cytochrome P450 4A11 isoform 1
NM_001319155.2	NP_001306084.1	cytochrome P450 4A11 isoform 2
NM_001363587.2	NP_001350516.1	cytochrome P450 4A11 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables alkane 1-monooxygenase activity	IDA IDA: Inferred from direct assay	18433732	GOA
enables arachidonate epoxygenase activity	IDA IDA: Inferred from direct assay	9618440	GOA
enables leukotriene-B4 20-monooxygenase activity	IDA IDA: Inferred from direct assay	9799565	GOA
enables long-chain fatty acid omega-hydroxylase activity	IDA IDA: Inferred from direct assay	15145985	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in arachidonate metabolic process	IDA IDA: Inferred from direct assay	10660572	GOA
involved in epoxygenase P450 pathway	IDA IDA: Inferred from direct assay	9618440	GOA
involved in leukotriene metabolic process	IDA IDA: Inferred from direct assay	9799565	GOA
involved in long-chain fatty acid metabolic process	IDA IDA: Inferred from direct assay	18433732	GOA
involved in positive regulation of icosanoid secretion	IMP IMP: Inferred from mutant phenotype	18391101	GOA
involved in pressure natriuresis	IEP IEP: Inferred from expression pattern	10660572	GOA
involved in renal water homeostasis	IEP IEP: Inferred from expression pattern	10660572	GOA
involved in sodium ion homeostasis	IEP IEP: Inferred from expression pattern	10660572	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	10660572	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	10660572	GOA
located in intracellular membrane-bounded organelle	IDA IDA: Inferred from direct assay	9618440	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CYP4A11 Protein Structure

p450

0
100
200
300
400
519 a.a.

Protein Preferred Names

Protein Names

cytochrome P450 4A11

20-HETE synthase

CYP4A11 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82342	Cytochrome P450 4A Antibody (YA2087)	WB, IHC-P, IP	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Peroxisomal Acyl-Coa Oxidase Deficiency

Pseudoneonatal Adrenoleukodystrophy	Straight-Chain Acyl-Coa Oxidase Deficiency
Pseudoadrenoleukodystrophy	PSEUDO-NALD
Pseudo-Neonatal Adrenoleukodystrophy	Acyl-Coa Oxidase Deficiency
Peroxisomal Acyl-Coenzyme A Oxidase	Acyl-Coenzyme A Oxidase Deficiency
Adrenoleukodystrophy, Pseudoneonatal	Deficiency, Peroxisomal Acyl-Coa Oxidase

Bietti Crystalline Corneoretinal Dystrophy

BCD	Bietti Crystalline Dystrophy
Bietti Tapetoretinal Degeneration With Marginal Corneal Dystrophy	Bietti Crystalline Retinopathy
Bietti'S Crystalline Dystrophy	Crystalline Retinopathy
Dystrophy, Corneoretinal, Crystalline, Bietti

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Gliosarcoma

Glioblastoma With Sarcomatous Component

Sarcomatous Glioblastoma

Autosomal Recessive Congenital Ichthyosis

Lamellar Ichthyosis	Congenital Ichthyosiform Erythroderma
Li	Congenital Nonbullous Ichthyosiform Erythroderma
Arci	Congenital Lamellar Ichthyosis
Nonbullous Congenital Ichthyosiform Erythroderma	Cie
Congenital Non-Bullous Ichthyosiform Erythroderma	Erythrodermic Ichthyosis
Nbcie	Ncie
Non-Bullous Congenital Ichthyosiform Erythroderma	Collodion Baby
Ichthyosis, Lamellar	Non Bullous Congenital Ichthyosiform Erythroderma
Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form	Ichthyosiform Erythroderma, Congenital, Nonbullous, 1
Collodion Baby Syndrome	Ichthyoses, Lamellar
Nbie	Nonbullous Ichthyosiform Erythroderma
Classic Lamellar Ichthyosis	Ichthyosiform Erythroderma Nonbullous Congenital
Ichthyosiform Erythroderma Congenital	Ichthyosis, Congenital, Autosomal Recessive
Ichthyosiform Erythroderma, Congenital	Collodion Fetus
Non-Bullous Ichthyosiform Erythroderma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-151810	TP0472993	Inhibitor	98.69%	Unkown
HY-151809	CYP4A11/CYP4F2-IN-1	Inhibitor	99.82%	Unkown
HY-149770	CYP4A11/CYP4F2-IN-2	Inhibitor	/	Unkown
HY-E70477	Human CYP4A11,Low-Reductase		/	Unkown
HY-E70478	Human CYP4A11,High-Reductase		/	Unkown
HY-E70489	Human CYP4A11,High-Reductase+b5		/	Unkown
HY-RS03476	CYP4A11 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03478	CYP4F11 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W472509	11-HETE	Activator	/	Unkown

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