CYP4B1 - cytochrome P450 family 4 subfamily B member 1 Gene

Homo sapiens

Also known as CYPIVB1; P-450HP

Gene ID: 1580 | Gene type: protein coding

About CYP4B1

Cytogenetic location: 1p33 Genomic coordinates (GRCh38): 1:46,799,046-46,819,413 (from NCBI)

This gene has 14 transcripts (splice variants), 182 orthologues and 12 paralogues. Biased expression in lung (RPKM 169.4), fat (RPKM 49.5) and 3 other tissues.

Summary

This gene encodes a member of the Cytochrome P450 superfamily of Enzymes. The Cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of Cholesterol, Steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jan 2016]

CYP4B1 Products(5)

mRNA	Protein	Name
NM_000779.4	NP_000770.2	cytochrome P450 4B1 isoform b
NM_001099772.2	NP_001093242.1	cytochrome P450 4B1 isoform a
NM_001319161.2	NP_001306090.1	cytochrome P450 4B1 isoform c
NM_001319162.2	NP_001306091.1	cytochrome P450 4B1 isoform d
NM_001319163.2	NP_001306092.1	cytochrome P450 4B1 isoform e

CYP4B1 Protein Structure

p450

0
100
200
300
400
511 a.a.

Protein Preferred Names

Protein Names

cytochrome P450 4B1

cytochrome P450, family 4, subfamily B, polypeptide 1

Related Diseases

Diseases

Alias

Bladder Cancer

Urinary Bladder Cancer	Bladder Carcinoma
Urinary Bladder Carcinoma	Bladder Neoplasm
Bladder Tumor	Cancer, Bladder
Malignant Neoplasm Of Urinary Bladder	Carcinoma Of Bladder
Bladder Cancer, Somatic	Tumor Of The Bladder
Carcinoma Of Urinary Bladder	Bladder Carcinoma Urinary
Cancer Of The Urinary Bladder	Cancer, Urinary Bladder
Malignant Bladder Neoplasm	Malignant Bladder Tumor
Neoplasm Of The Bladder	Neoplasm Of The Urinary Bladder
Tumor Of The Urinary Bladder	Urinary Bladder Neoplasm
BLC	Urothelial Carcinoma Of The Bladder
Bladder Tumors	Urinary Bladder Neoplasms
Bladder Cancer Nos	Vesical Cancer Nos
Malignant Neoplasm Of Bladder, Part Unspecified	Malignant Tumour Of Urinary Bladder
Primary Malignant Neoplasm Of Bladder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03477	CYP4B1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CYP4B1	VGNC	VGNC:99874
Rattus norvegicus	CYP4B1	RGD	RGD:2480
Mus musculus	CYP4B1	MGD	MGI:103225
Canis familiaris	CYP4B1	VGNC	VGNC:50363
Felis catus	CYP4B1	VGNC	VGNC:103324

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