Ifnb1 - interferon beta 1, fibroblast Gene

Mus musculus

Also known as Ifb; IFNB; If1da1; IFN-beta

Gene ID: 15977 | Gene type: protein coding

About Ifnb1

Summary

Enables cytokine activity and type I interferon receptor binding activity. Involved in B cell proliferation; cellular response to virus; and type I interferon signaling pathway. Acts upstream of or within several processes, including cellular response to organic cyclic compound; defense response to Other organism; and negative regulation of osteoclast differentiation. Located in extracellular space. Is expressed in embryo and liver. Human ortholog(s) of this gene implicated in COVID-19. Orthologous to human IFNB1 (interferon beta 1). [provided by Alliance of Genome Resources, Apr 2022]

Ifnb1 Products(1)

mRNA	Protein	Name
NM_010510.2	NP_034640.1	interferon beta precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cytokine activity	IDA IDA: Inferred from direct assay	15240719	MGI
enables type I interferon receptor binding	IPI IPI: Inferred from physical interaction	23872679	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in B cell proliferation	IMP IMP: Inferred from mutant phenotype	14597717	MGI
acts upstream of or within adaptive immune response	IDA IDA: Inferred from direct assay	17277142	MGI
acts upstream of or within cellular response to dexamethasone stimulus	IDA IDA: Inferred from direct assay	21606371	MGI
involved in cellular response to dsRNA	IEP IEP: Inferred from expression pattern	18596219	MGI
involved in cellular response to virus	IDA IDA: Inferred from direct assay	24882218	MGI
acts upstream of or within defense response to bacterium	IDA IDA: Inferred from direct assay	15240719	MGI
acts upstream of or within defense response to virus	IDA IDA: Inferred from direct assay	17277142	MGI
involved in defense response to virus	IDA IDA: Inferred from direct assay	10708458	MGI
involved in defense response to virus	IMP IMP: Inferred from mutant phenotype	27129230	MGI
acts upstream of or within humoral immune response	IDA IDA: Inferred from direct assay	17277142	MGI
involved in negative regulation of Lewy body formation	IMP IMP: Inferred from mutant phenotype	26451483	MGI
acts upstream of or within negative regulation of osteoclast differentiation	IDA IDA: Inferred from direct assay	17442941	MGI
involved in neuron cellular homeostasis	IMP IMP: Inferred from mutant phenotype	26451483	MGI
involved in positive regulation of autophagy	IMP IMP: Inferred from mutant phenotype	26451483	MGI
involved in type I interferon-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	27129230	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	17277142	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

interferon beta

interferon 1da1

Recombinant Ifnb1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73130	IFN-beta Protein, Mouse (HEK293)	P01575 (I22-N182)	≥95%
HY-P73131	IFN-beta Protein, Mouse (HEK293, Fc)	P01575 (I22-N182)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-138682	STING-IN-2	Inhibitor	99.71%	Unkown
HY-RS06585	IFNB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990036	Dazukibart	Inhibitor	99.76%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ifnb1	NCBI	NCBI:3456
Macaca mulatta	Ifnb1	NCBI	NCBI:711414

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