DGKQ - diacylglycerol kinase theta Gene

Homo sapiens

Also known as DAGK; DAGK4; DAGK7

Gene ID: 1609 | Gene type: protein coding

About DGKQ

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:958,887-973,569 (from NCBI)

This gene has 5 transcripts (splice variants), 186 orthologues and 9 paralogues. Ubiquitous expression in small intestine (RPKM 9.9), duodenum (RPKM 8.3) and 25 other tissues.

Summary

The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. [provided by RefSeq, Jul 2008]

DGKQ Products(1)

mRNA	Protein	Name
NM_001347.4	NP_001338.2	diacylglycerol kinase theta

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP-dependent diacylglycerol kinase activity	IDA IDA: Inferred from direct assay	9099683	GOA
enables ATP-dependent diacylglycerol kinase activity	IMP IMP: Inferred from mutant phenotype	23091060	GOA
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	17664281	GOA
enables kinase binding	IPI IPI: Inferred from physical interaction	15632189	GOA
enables phospholipase binding	IPI IPI: Inferred from physical interaction	12799190	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10066731	GOA
enables transmembrane receptor protein tyrosine kinase activator activity	IGI IGI: Inferred from genetic interaction	22732145	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	24369117	GOA
involved in cAMP-mediated signaling	IDA IDA: Inferred from direct assay	17664281	GOA
involved in cellular response to bile acid	IMP IMP: Inferred from mutant phenotype	23767959	GOA
involved in diacylglycerol metabolic process	IDA IDA: Inferred from direct assay	9099683	GOA
involved in glycerolipid metabolic process	IDA IDA: Inferred from direct assay	22627129	GOA
involved in lipid phosphorylation	IDA IDA: Inferred from direct assay	9099683	GOA
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	24369117	GOA
involved in negative regulation of peptidyl-threonine phosphorylation	IDA IDA: Inferred from direct assay	22732145	GOA
involved in negative regulation of peptidyl-threonine phosphorylation	IGI IGI: Inferred from genetic interaction	22732145	GOA
involved in phosphatidic acid biosynthetic process	IDA IDA: Inferred from direct assay	9099683	GOA
involved in phosphatidic acid biosynthetic process	IMP IMP: Inferred from mutant phenotype	23610160	GOA
involved in phospholipase C-activating G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	15632189	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	24369117	GOA
involved in positive regulation of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	22732145	GOA
involved in regulation of G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	22732145	GOA
involved in regulation of TORC1 signaling	IMP IMP: Inferred from mutant phenotype	23767959	GOA
involved in regulation of cholesterol metabolic process	IMP IMP: Inferred from mutant phenotype	24369117	GOA
involved in regulation of cortisol biosynthetic process	IMP IMP: Inferred from mutant phenotype	24369117	GOA
involved in regulation of gluconeogenesis	IMP IMP: Inferred from mutant phenotype	23767959	GOA
involved in regulation of progesterone biosynthetic process	IMP IMP: Inferred from mutant phenotype	24369117	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17664281	GOA
involved in response to cAMP	IDA IDA: Inferred from direct assay	23610160	GOA
involved in thrombin-activated receptor signaling pathway	IDA IDA: Inferred from direct assay	15632189	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15632189	GOA
located in cytoskeleton	IDA IDA: Inferred from direct assay	10066731	GOA
located in cytosol	IDA IDA: Inferred from direct assay	10066731	GOA
located in endosome	IDA IDA: Inferred from direct assay	22732145	GOA
located in nuclear speck	IDA IDA: Inferred from direct assay	12799190	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15632189	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	10066731	GOA
located in vesicle membrane	IDA IDA: Inferred from direct assay	23091060	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DGKQ Protein Structure

C1_1

DAGK_cat

DAGK_acc

0
200
400
600
800
942 a.a.

Protein Preferred Names

Protein Names

diacylglycerol kinase theta

DAG kinase theta

DGKQ Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DGKQ	P52824	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Prey Pooling	32296183
Intra	DGKQ	P52824	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Retinal Degeneration

Degeneration Of Retina

Gaucher Disease, Type I

Glucocerebrosidase Deficiency	Acid Beta-Glucosidase Deficiency
Gba Deficiency	GD1
Gd I	Gaucher Disease, Noncerebral Juvenile
Gaucher Disease Type 1	Gaucher Disease Type I
Gaucher'S Disease Type I	Gaucher Disease
Gd 1	Non-Cerebral Juvenile Gaucher Disease
GD	Gaucher Disease 1
Adult Non-Neuronopathic Gaucher Disease	Noncerebral Juvenile Gaucher Disease
Type 1 Gaucher Disease	Gaucher Disease, Type 1

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03723	DGKQ Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	DGKQ	VGNC	VGNC:28031
Mus musculus	DGKQ	MGD	MGI:102918
Felis catus	DGKQ	VGNC	VGNC:61463
Rattus norvegicus	DGKQ	RGD	RGD:2320722
Macaca mulatta	DGKQ	VGNC	VGNC:71788
Canis familiaris	DGKQ	VGNC	VGNC:39923

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