2. Gene
  3. CLEC14A - C-type lectin domain containing 14A Gene

CLEC14A - C-type lectin domain containing 14A Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as CEG1; EGFR-5; C14orf27

Gene ID: 161198 | Gene type: protein coding

About CLEC14A

Cytogenetic location: 14q21.1 Genomic coordinates (GRCh38): 14:38,254,000-38,256,093 (from NCBI)

This gene has 1 transcript (splice variant), 288 orthologues and 8 paralogues.

Summary

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. This family member plays a role in cell-cell adhesion and angiogenesis. It functions in filopodia formation, cell migration and tube formation. Due to its presence at higher levels in tumor endothelium than in normal tissue endothelium, it is considered to be a candidate for tumor vascular targeting. [provided by RefSeq, Jan 2012]

CLEC14A Products(1)

mRNA Protein Name
NM_175060.3 NP_778230.1 C-type lectin domain family 14 member A precursor
Protein Preferred Names Protein Names

C-type lectin domain family 14 member A

ClECT and EGF-like domain containing protein

CLEC14A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
CLEC14A Q86T13 MGST2 Homo sapiens Q99735
Validated Y2H
32296183
Intra
CLEC14A Q86T13 CLDN19 Homo sapiens Q8N6F1-2
Validated Y2H
32296183
Intra
CLEC14A Q86T13 TMEM243 Homo sapiens Q9BU79
Validated Y2H
32296183
Intra
CLEC14A Q86T13 LHFPL5 Homo sapiens Q8TAF8
Validated Y2H
32296183
Intra
CLEC14A Q86T13 MALL Homo sapiens Q13021
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CLEC14A Proteins

Cat. No. Product Name Accession Purity
HY-P700693 CLEC14A Protein, Human (HEK293, His) Q86T13 (E22-A397) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02783 CLEC14A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CLEC14A VGNC VGNC:27425
Mus musculus CLEC14A MGD MGI:1914114
Macaca mulatta CLEC14A VGNC VGNC:108292
Rattus norvegicus CLEC14A RGD RGD:1306232
Canis familiaris CLEC14A VGNC VGNC:39327
Felis catus CLEC14A VGNC VGNC:60943
Others CLEC14A NCBI