MALL - mal, T cell differentiation protein like Gene

Homo sapiens

Also known as BENE

Gene ID: 7851 | Gene type: protein coding

About MALL

Cytogenetic location: 2q13 Genomic coordinates (GRCh38): 2:110,083,870-110,118,139 (from NCBI)

This gene has 3 transcripts (splice variants), 126 orthologues and 14 paralogues. Biased expression in esophagus (RPKM 101.4), duodenum (RPKM 83.6) and 10 other tissues.

Summary

This gene encodes an element of the machinery for raft-mediated trafficking in endothelial cells. The encoded protein, a member of the MAL proteolipid family, predominantly localizes in glycolipid- and cholesterol-enriched membrane (GEM) rafts. It interacts with caveolin-1. [provided by RefSeq, Jul 2008]

MALL Products(3)

mRNA	Protein	Name
NM_001371559.1	NP_001358488.1	MAL-like protein isoform 2
NM_001371560.1	NP_001358489.1	MAL-like protein isoform 3
NM_005434.5	NP_005425.1	MAL-like protein isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11294831	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi membrane	IDA IDA: Inferred from direct assay	11294831	GOA
located in clathrin-coated vesicle	IDA IDA: Inferred from direct assay	11294831	GOA
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	11294831	GOA
located in membrane raft	IDA IDA: Inferred from direct assay	11294831	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	11294831	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MALL Protein Structure

MARVEL

0
100
153 a.a.

Protein Preferred Names

Protein Names

MAL-like protein

Related Diseases

Diseases

Alias

Cascade Stomach

Hourglass Stricture Or Stenosis Of Stomach	Hourglass Contraction Of Stomach
Hourglass Stenosis Of Stomach	Hourglass Stricture Of Stomach

Joubert Syndrome 4

JBTS4	Joubert Syndrome With Renal Defect
Joubert Syndrome With Renal Anomalies	Js-R
Joubert Syndrome, Type 4

Nephronophthisis

Medullary Cystic Disease	Medullary Cystic Kidney
Nph	Nphp
Kidney Disease, Cystic, Medullary

Leukoencephalopathy With Vanishing White Matter

Cree Leukoencephalopathy	Vanishing White Matter Disease
Ovarioleukodystrophy	Vanishing White Matter Leukodystrophy
Childhood Ataxia With Central Nervous System Hypomyelinization	Cach
Cach Syndrome	Myelinosis Centralis Diffusa
VWM	Cle
Childhood Ataxia With Central Nervous System Hypomyelination	Childhood Ataxia With Diffuse Central Nervous System Hypomyelination
Cach/Vwm	Cach/Vwm Syndrome
Childhood Ataxia With Central Nervous System Hypomyelination/Vanishing White Matter	Cree Leukoencehalopathy
Late Infantile Cach Syndrome	Juvenile Or Adult Cach Syndrome
Congenital Or Early Infantile Cach Syndrome	Leukodystrophy With Vanishing White Matter

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07993	MALL Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MALL	VGNC	VGNC:31154
Canis familiaris	MALL	VGNC	VGNC:42934
Felis catus	MALL	VGNC	VGNC:68141
Rattus norvegicus	MALL	RGD	RGD:1310869
Mus musculus	MALL	MGD	MGI:2385152
Susscrofa domestica	MALL	NCBI
Macaca mulatta	MALL	NCBI	NCBI:696102
Others	MALL	NCBI

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