Il2rg - interleukin 2 receptor, gamma chain Gene

Mus musculus

Also known as gc; p64; [g]c; CD132; gamma(c)

Gene ID: 16186 | Gene type: protein coding

About Il2rg

Summary

This gene encodes a transmembrane protein that is a common subunit of several interleukin receptor complexes. These receptors are comprised of alpha and beta subunits in addition to this gamma subunit. Signalling through this pathway in important in immune cell differentiation and function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]

Il2rg Products(2)

mRNA	Protein	Name
NM_001308535.1	NP_001295464.1	cytokine receptor common subunit gamma isoform b precursor
NM_013563.4	NP_038591.1	cytokine receptor common subunit gamma isoform a precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables interleukin-2 binding	IPI IPI: Inferred from physical interaction	8262055	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of B cell differentiation	IMP IMP: Inferred from mutant phenotype	9252128	MGI
acts upstream of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation	IMP IMP: Inferred from mutant phenotype	16227984	MGI
acts upstream of T cell differentiation in thymus	IMP IMP: Inferred from mutant phenotype	9252128	MGI
acts upstream of gene expression	IMP IMP: Inferred from mutant phenotype	18958875	MGI
acts upstream of lymphocyte differentiation	IMP IMP: Inferred from mutant phenotype	23918385	MGI
acts upstream of mature B cell differentiation	IMP IMP: Inferred from mutant phenotype	23918385	MGI
acts upstream of or within positive regulation of B cell differentiation	IMP IMP: Inferred from mutant phenotype	9252128	MGI
acts upstream of or within positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation	IMP IMP: Inferred from mutant phenotype	16227984	MGI
acts upstream of or within positive regulation of T cell differentiation in thymus	IMP IMP: Inferred from mutant phenotype	9252128	MGI
acts upstream of or within positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	18958875	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	9916699	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	8262055	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cytokine receptor common subunit gamma

IL-2 receptor subunit gamma	IL-2R subunit gamma
common gamma chain	gamma C receptor
interleukin-2 receptor subunit gamma

Recombinant Il2rg Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70693	IL-2R gamma/CD132 Protein, Mouse (HEK293, His)	Q3UPA9 (S25-A263)	≥95%
HY-P74807	IL-2R gamma/CD132 Protein, Mouse (HEK293, His-Fc)	P34902/NP_038591.1 (W23-A263)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06750	IL2RG Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Il2rg	NCBI	NCBI:3561
Macaca fascicularis	Il2rg	NCBI	NCBI:102144912

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