Il7 - interleukin 7 Gene

Mus musculus

Also known as Il-7; hlb368; A630026I06Rik

Gene ID: 16196 | Gene type: protein coding

About Il7

Summary

The protein encoded by this gene is a hematopoietic growth factor important for B and T cell development. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]

Il7 Products(4)

mRNA	Protein	Name
NM_001313888.1	NP_001300817.1	interleukin-7 isoform b
NM_001313889.1	NP_001300818.1	interleukin-7 isoform c
NM_001313890.1	NP_001300819.1	interleukin-7 isoform b
NM_008371.5	NP_032397.1	interleukin-7 isoform a precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cytokine activity	IDA IDA: Inferred from direct assay	12490655	MGI
enables growth factor activity	IDA IDA: Inferred from direct assay	12970760	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of B cell proliferation	IGI IGI: Inferred from genetic interaction	7671324	MGI
acts upstream of or within T cell lineage commitment	IMP IMP: Inferred from mutant phenotype	9252127	MGI
acts upstream of or within bone resorption	IDA IDA: Inferred from direct assay	12490655	MGI
acts upstream of extrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	10429671	MGI
acts upstream of or within homeostasis of number of cells within a tissue	IMP IMP: Inferred from mutant phenotype	9252127	MGI
acts upstream of or within negative regulation of catalytic activity	IDA IDA: Inferred from direct assay	8950980	MGI
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	10429671	MGI
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IDA IDA: Inferred from direct assay	8950980	MGI
acts upstream of organ growth	IGI IGI: Inferred from genetic interaction	9252127	MGI
acts upstream of organ growth	IMP IMP: Inferred from mutant phenotype	9252127	MGI
acts upstream of or within positive regulation of B cell differentiation	IDA IDA: Inferred from direct assay	16797412	MGI
acts upstream of or within positive regulation of B cell proliferation	IDA IDA: Inferred from direct assay	12970760	MGI
acts upstream of or within positive regulation of B cell proliferation	IGI IGI: Inferred from genetic interaction	7671324	MGI
acts upstream of or within positive regulation of T cell differentiation	IDA IDA: Inferred from direct assay	12431371	MGI
acts upstream of or within positive regulation of gene expression	IDA IDA: Inferred from direct assay	16797412	MGI
acts upstream of or within positive regulation of organ growth	IGI IGI: Inferred from genetic interaction	9252127	MGI
acts upstream of or within positive regulation of organ growth	IMP IMP: Inferred from mutant phenotype	9252127	MGI
acts upstream of or within regulation of gene expression	IDA IDA: Inferred from direct assay	8950980	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	9252127	MGI
acts upstream of or within regulation of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	29581031	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	8950980	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

interleukin-7

Recombinant Il7 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7082	IL-7 Protein, Mouse (CHO)	P10168/Q544C8/NP_032397.1 (E26-I154)	≥95%
HY-P70566	IL-7 Protein, Mouse (HEK293, His)	P10168/Q544C8/NP_032397.1 (E26-I154)	≥95%
HY-P73226	IL-7 Protein, Mouse	P10168/Q544C8/NP_032397.1 (E26-I154)	≥95%
HY-P700217AF	Animal-Free IL-7 Protein, Mouse (His)	P10168/Q544C8/NP_032397.1 (E26-I154)	≥95%

Related Agents

Clinical Phase

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99412	Lusvertikimab	Antagonist	/	Phase 2
HY-P99908	Efineptakin alfa	Activator	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06779	IL7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06780	IL7R Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Il7	NCBI	NCBI:3574
Macaca fascicularis	Il7	NCBI	NCBI:102135001
Rattus norvegicus	Il7	NCBI	NCBI:25647

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