Inhba - inhibin beta-A Gene

Mus musculus

Gene ID: 16323 | Gene type: protein coding

About Inhba

Summary

This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. The encoded protein also plays a role in eye, tooth and testis development. Homozygous knockout mice for this gene lack whiskers and exhibit tooth and palate defects, leading to neonatal lethality. [provided by RefSeq, Aug 2016]

Inhba Products(1)

mRNA	Protein	Name
NM_008380.2	NP_032406.1	inhibin beta A chain preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	1646080	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Sertoli cell differentiation	IMP IMP: Inferred from mutant phenotype	32274496	MGI
acts upstream of or within androgen metabolic process	IMP IMP: Inferred from mutant phenotype	32274496	MGI
acts upstream of or within androst-4-ene-3,17-dione biosynthetic process	IMP IMP: Inferred from mutant phenotype	32954300	MGI
involved in eyelid development in camera-type eye	IGI IGI: Inferred from genetic interaction	14551263	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	32274496	MGI
acts upstream of or within hematopoietic progenitor cell differentiation	IDA IDA: Inferred from direct assay	7799920	MGI
acts upstream of or within lipid metabolic process	IMP IMP: Inferred from mutant phenotype	32274496	MGI
acts upstream of or within male gonad development	IMP IMP: Inferred from mutant phenotype	32274496	MGI
acts upstream of or within mesoderm formation	IDA IDA: Inferred from direct assay	7799920	MGI
acts upstream of or within mesodermal cell differentiation	IDA IDA: Inferred from direct assay	7799920	MGI
involved in positive regulation of DNA-templated transcription	IGI IGI: Inferred from genetic interaction	14551263	MGI
involved in positive regulation of ovulation	IMP IMP: Inferred from mutant phenotype	17609433	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10391928	MGI
acts upstream of or within steroid biosynthetic process	IMP IMP: Inferred from mutant phenotype	32954300	MGI
acts upstream of or within steroid metabolic process	IMP IMP: Inferred from mutant phenotype	32274496	MGI
acts upstream of or within testosterone biosynthetic process	IMP IMP: Inferred from mutant phenotype	32274496	MGI
acts upstream of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10391928	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	8133077	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

inhibin beta A chain

activin A

activin beta-A chain

Recombinant Inhba Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73241	Activin A Protein, Mouse (HEK293, His)	Q3UY39/NP_032406.1 (S21-S424)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06813	INHBA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990720	Elritercept	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Inhba	NCBI	NCBI:3624
Rattus norvegicus	Inhba	NCBI	NCBI:29200

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