INHBA - inhibin subunit beta A Gene

Homo sapiens

Also known as EDF; FRP

Gene ID: 3624 | Gene type: protein coding

About INHBA

Cytogenetic location: 7p14.1 Genomic coordinates (GRCh38): 7:41,685,114-41,705,406 (from NCBI)

This gene has 5 transcripts (splice variants), 281 orthologues, 31 paralogues and is associated with 1 phenotype. Broad expression in endometrium (RPKM 12.3), gall bladder (RPKM 11.3) and 15 other tissues.

Summary

This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. The encoded protein also plays a role in eye, tooth and testis development. Elevated expression of this gene may be associated with Cancer cachexia in human patients. [provided by RefSeq, Aug 2016]

INHBA Products(1)

mRNA	Protein	Name
NM_002192.4	NP_002183.1	inhibin beta A chain preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cytokine activity	IDA IDA: Inferred from direct assay	9884026	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	2575216	GOA
enables peptide hormone binding	IPI IPI: Inferred from physical interaction	16198295	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	2575216	GOA
enables type II activin receptor binding	IPI IPI: Inferred from physical interaction	7890768	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in GABAergic neuron differentiation	IDA IDA: Inferred from direct assay	25804741	GOA
involved in activin receptor signaling pathway	IDA IDA: Inferred from direct assay	9884026	GOA
involved in endodermal cell differentiation	IDA IDA: Inferred from direct assay	21828274	GOA
involved in extrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	9884026	GOA
involved in hair follicle development	IGI IGI: Inferred from genetic interaction	10932194	GOA
involved in hematopoietic progenitor cell differentiation	IDA IDA: Inferred from direct assay	15451575	GOA
involved in hemoglobin biosynthetic process	IDA IDA: Inferred from direct assay	1310063	GOA
involved in male gonad development	IGI IGI: Inferred from genetic interaction	10932194	GOA
involved in negative regulation of G1/S transition of mitotic cell cycle	IDA IDA: Inferred from direct assay	9884026	GOA
involved in negative regulation of cell growth	IDA IDA: Inferred from direct assay	9884026	GOA
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	11948405	GOA
involved in odontogenesis	IGI IGI: Inferred from genetic interaction	10932194	GOA
involved in ovarian follicle development	IGI IGI: Inferred from genetic interaction	10932194	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	21281489	GOA
involved in positive regulation of SMAD protein signal transduction	IDA IDA: Inferred from direct assay	19736306	GOA
involved in positive regulation of erythrocyte differentiation	IDA IDA: Inferred from direct assay	9032295	GOA
involved in positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	IDA IDA: Inferred from direct assay	8267637	GOA
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	23812417	GOA
involved in positive regulation of protein metabolic process	IDA IDA: Inferred from direct assay	21828274	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12702211	GOA
involved in progesterone secretion	IGI IGI: Inferred from genetic interaction	10932194	GOA
involved in regulation of follicle-stimulating hormone secretion	IGI IGI: Inferred from genetic interaction	10932194	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11948405	GOA
involved in roof of mouth development	IGI IGI: Inferred from genetic interaction	10932194	GOA
involved in striatal medium spiny neuron differentiation	IDA IDA: Inferred from direct assay	25804741	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of activin A complex	IDA IDA: Inferred from direct assay	7890768	GOA
part of enzyme activator complex	IDA IDA: Inferred from direct assay	12660162	GOA
located in extracellular region	IDA IDA: Inferred from direct assay	12213882	GOA
part of inhibin A complex	IDA IDA: Inferred from direct assay	7890768	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

INHBA Protein Structure

TGFb_propeptide

TGF_beta

0
100
200
300
400
426 a.a.

Protein Preferred Names

Protein Names

inhibin beta A chain

FSH-releasing protein

INHBA Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	INHBA	P08476	Fst	Rattus norvegicus	P21674	ITC	16482217

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant INHBA Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70311	Activin A Protein, Human/Mouse/Rat (HEK293)	P08476 (G311-S426)	≥95%
HY-P700159AF	Animal-Free Activin A Protein, Human/Mouse/Rat (His)	P08476 (G311-S426)	≥95%

INHBA Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83035	Inhibin beta A Antibody (YA2780)	WB	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Ovary Adenocarcinoma

Ovarian Adenocarcinoma	Adenocarcinoma Of The Ovary
Ovarian Adenoacanthoma	Adenocarcinoma Of Ovary

Sex Cord-Gonadal Stromal Tumor

Sex Cord-Gonadal Stromal Tumour	Sex Cord Stromal Tumour
Sex Cord-Stromal Neoplasm	Specialized Gonadal Neoplasm
Specialized Gonadal Tumor	Specialized Gonadal Tumour
Sex Cord-Gonadal Stromal Tumors	Sex Cord-Stromal Tumor
Malignant Testicular Sex Cord-Stromal Tumor	Sex Cord Stromal Tumor Of Testis

Clear Cell Adenocarcinoma

Mesonephroma	Water-Clear Cell Adenocarcinoma
Adenocarcinoma, Clear Cell	Malignant Mesonephroma
Mesonephroid Clear Cell Carcinoma	Mesonephroma, Malignant
Water-Clear Cell Carcinoma	Wolffian Duct Neoplasm
Adenocarcinoma Clear Cell	Mesonephric Tumor

Esophageal Cancer

Esophageal Carcinoma	Carcinoma Of Esophagus
Esophageal Squamous Cell Carcinoma, Somatic	Esophageal Carcinoma, Somatic
Esophagus Cancer	Gastric Cardia Adenocarcinoma
Esophageal Neoplasms	Esophageal Cancer, Somatic
Cancer Of Esophagus	Cancer Of Oesophagus
Carcinoma Of Oesophagus	Ca Lower Third Oesophagus
Ca Middle Third Oesophagus	Malignant Neoplasm Of Distal Third Of Esophagus
Malignant Neoplasm Of Lower Third Of Oesophagus	Malignant Neoplasm Of Middle Third Of Oesophagus
Malignant Neoplasm Of Proximal Third Of Esophagus	Malignant Neoplasm Of Upper Third Esophagus
Malignant Tumor Of Abdominal Esophagus	Malignant Tumor Of Distal Third Of Esophagus
Malignant Tumor Of Proximal Third Of Esophagus	Malignant Tumor Of The Middle Third Of The Esophagus
ESCR	Aerodigestive Tract Cancer
Escc	Esophageal Squamous Cell Carcinoma
Cancer, Esophageal	Malignant Neoplasm Of Esophagus
Squamous Cell Carcinoma Of Esophagus	Malignant Neoplasm Of Middle Third Of Esophagus

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06813	INHBA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990733	Cibotercept	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	INHBA	MGD	MGI:96570
Macaca mulatta	INHBA	VGNC	VGNC:81334
Canis familiaris	INHBA	VGNC	VGNC:42021
Bos taurus	INHBA	VGNC	VGNC:30200
Felis catus	INHBA	VGNC	VGNC:80600
Rattus norvegicus	INHBA	RGD	RGD:62074
Others	INHBA	NCBI

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