2. Gene
  3. Irs1 - insulin receptor substrate 1 Gene

Irs1 - insulin receptor substrate 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as G972R; IRS-1

Gene ID: 16367 | Gene type: protein coding

About Irs1

Summary

Enables phosphatidylinositol 3-kinase binding activity and protein kinase binding activity. Involved in cellular response to fatty acid. Acts upstream of or within several processes, including cellular response to Insulin stimulus; positive regulation of phosphatidylinositol 3-kinase activity; and protein kinase B signaling. Located in several cellular components, including ciliary basal body; nucleus; and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; and type 2 diabetes mellitus. Orthologous to human IRS1 (Insulin Receptor substrate 1). [provided by Alliance of Genome Resources, Apr 2022]

Irs1 Products(1)

mRNA Protein Name
NM_010570.4 NP_034700.2 insulin receptor substrate 1
Protein Preferred Names Protein Names

insulin receptor substrate 1

Related Agents

Clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-153479 Aganirsen Inhibitor / Phase 3
HY-145935 NT219 Inhibitor 98.57% Phase 2
HY-115461 MID-1 Inhibitor 99.36% Phase 2
Pre-clinical Phase
Bioactive Molecules (12)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-100037 NT157 Inhibitor 99.38% Unkown
HY-N0479 Licarin B Activator 99.93% Unkown
HY-161321 PTP1B-IN-24 95.01% Unkown
HY-N3628 Coronarin A Inhibitor ≥98.0% Unkown
HY-15113 Y-29794 Inhibitor / Unkown
HY-15113A Y-29794 tosylate Inhibitor / Unkown
HY-153479A Aganirsen sodium Inhibitor / Unkown
HY-162499 MY17 Inhibitor / Unkown
HY-N3542 Carpachromene Inhibitor / Unkown
HY-P5433F IRS-1 Peptide, FAM labeled Substrate / Unkown
HY-RS06917 IRS1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-107758 Y-29794 oxalate Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Irs1 NCBI NCBI:3667
Macaca fascicularis Irs1 NCBI NCBI:102117978
Rattus norvegicus Irs1 NCBI NCBI:25467