2. Metabolic Enzyme/Protease Protein Tyrosine Kinase/RTK PI3K/Akt/mTOR
  3. Phosphatase Insulin Receptor Akt
  4. PTP1B-IN-24

PTP1B-IN-24 (Compound 9) is a reversible PTP1B inhibitor with an IC50 value of 1.4 μM, and PTP1B-IN-24 can enhance the thermal stability of PTP1B. PTP1B-IN-24 can restore PA- (HY-N0830) induced insulin resistance by increasing the phosphorylation levels of IRS1 and AKT.

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PTP1B-IN-24 Chemical Structure

PTP1B-IN-24 Chemical Structure

CAS No. : 2221707-61-3

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PTP1B-IN-24 Related Antibodies

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Description

PTP1B-IN-24 (Compound 9) is a reversible PTP1B inhibitor with an IC50 value of 1.4 μM, and PTP1B-IN-24 can enhance the thermal stability of PTP1B. PTP1B-IN-24 can restore PA- (HY-N0830) induced insulin resistance by increasing the phosphorylation levels of IRS1 and AKT[1].

IC50 & Target

Akt

1.4 μM (IC50)

In Vitro

PTP1B-IN-24 (0-32 μM; 24 h) doesn't affect cell viability in LO2 cells. PTP1B-IN-24 (1-2 μM; 24 h) improves PA (0.4 mM; 24 h)-induced insulin resistance in HepG2 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PTP1B-IN-24 Related Antibodies

Western Blot Analysis[1]

Cell Line: HepG2
Concentration: 1 μM; 2 μM
Incubation Time: 24 h
Result: Enhanced the phosphorylated expression of IRS1 (Y632) and Akt (S473).
Molecular Weight

420.44

Formula

C22H16N2O5S
CAS No.
SMILES

O=C(S/1)N(CC(NC2=CC=C(C)C=C2)=O)C(C1=C\C3=COC4=CC=CC=C4C3=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PTP1B-IN-24 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PTP1B-IN-242221707-61-3PhosphataseInsulin ReceptorAktPKBProtein kinase BHepG2insulin resistanceLO2Inhibitorinhibitorinhibit

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