IFNLR1 - interferon lambda receptor 1 Gene

Homo sapiens

Also known as IFNLR; LICR2; IL28RA; CRF2/12; IL-28R1

Gene ID: 163702 | Gene type: protein coding

About IFNLR1

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:24,154,168-24,187,289 (from NCBI)

This gene has 5 transcripts (splice variants), 161 orthologues and 11 paralogues. Broad expression in small intestine (RPKM 5.6), lymph node (RPKM 4.0) and 22 other tissues.

Summary

The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral Infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

IFNLR1 Products(3)

mRNA	Protein	Name
NM_170743.4	NP_734464.1	interferon lambda receptor 1 isoform 1 precursor
NM_173064.3	NP_775087.1	interferon lambda receptor 1 isoform 2
NM_173065.3	NP_775088.1	interferon lambda receptor 1 isoform 3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12469119	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of cellular respiration	IMP IMP: Inferred from mutant phenotype	25930096	GOA
involved in regulation of defense response to virus by host	IDA IDA: Inferred from direct assay	12469119	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of interleukin-28 receptor complex	IDA IDA: Inferred from direct assay	12469119	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IFNLR1 Protein Structure

Tissue_fac

0
100
200
300
400
520 a.a.

Protein Preferred Names

Protein Names

interferon lambda receptor 1

CRF2-12

IFNLR1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	IFNLR1	Q8IU57	ANKRD46	Homo sapiens	Q86W74-2	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Psoriasis 12

PSORS12	Psoriasis Susceptibility 12
Psoriasis 12, Susceptibility To

Zika Virus Congenital Syndrome

Zikv Congenital Infection

Immunodeficiency 27a

IMD27A	Autosomal Recessive Ifngr1 Deficiency
Autosomal Recessive Immunodeficiency 27a, Mycobacteriosis	Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Ifngammar1 Deficiency
Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Interferon Gamma Receptor 1 Deficiency	Autosomal Recessive Msmd Due To Partial Ifngammar1 Deficiency
Autosomal Recessive Msmd Due To Partial Interferon Gamma Receptor 1 Deficiency	Immunodeficiency 27a, Mycobacteriosis, Autosomal Recessive
Ifngr1 Deficiency, Autosomal Recessive	Immunodeficiency 27a, Mycobacteriosis, Ar
Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Ifngammar1 Deficiency	Msmd Due To Complete Ifngammar1 Deficiency
Msmd Due To Complete Interferon Gamma Receptor 1 Deficiency	Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Interferon Gamma Receptor 1 Deficiency
Familial Disseminated Atypical Mycobacterial Infection	Interferon Gamma, Receptor 1, Deficiency
Immunodeficiency, Type 27a, Mycobacteriosis, Ar	Mycobacterial Disease, Mendelian Susceptibility To

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06595	IFNLR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	IFNLR1	MGD	MGI:2429859
Canis familiaris	IFNLR1	VGNC	VGNC:41881
Rattus norvegicus	IFNLR1	RGD	RGD:1562689
Felis catus	IFNLR1	VGNC	VGNC:107564
Bos taurus	IFNLR1	VGNC	VGNC:30061
Macaca mulatta	IFNLR1	VGNC	VGNC:73415
Others	IFNLR1	NCBI

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