Itgb3 - integrin beta 3 Gene

Mus musculus

Also known as CD61; GP3A; INGRB3

Gene ID: 16416 | Gene type: protein coding

About Itgb3

Summary

Enables Integrin binding activity and protein kinase C binding activity. Involved in several processes, including positive regulation of T cell migration; positive regulation of osteoblast proliferation; and regulation of serotonin uptake. Acts upstream of or within several processes, including cellular response to platelet-derived growth factor stimulus; positive regulation of cell-substrate adhesion; and positive regulation of fibroblast migration. Located in several cellular components, including external side of plasma membrane; focal adhesion; and glutamatergic synapse. Part of alpha9-beta1 integrin-ADAM8 complex and alphav-beta3 integrin-PKCalpha complex. Is integral component of synaptic membrane. Is expressed in several structures, including bladder; dorsal aorta; gut; liver; and lung. Used to study Glanzmann's thrombasthenia and platelet-type bleeding disorder 16. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; autoimmune thrombocytopenic purpura; blood platelet disease (multiple); end stage renal disease; and non-arteritic anterior ischemic optic neuropathy. Orthologous to human ITGB3 (Integrin subunit beta 3). [provided by Alliance of Genome Resources, Apr 2022]

Itgb3 Products(1)

mRNA	Protein	Name
NM_016780.2	NP_058060.2	integrin beta-3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	21670307	MGI
enables integrin binding	IPI IPI: Inferred from physical interaction	8601592	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12867986	MGI
enables protein kinase C binding	IPI IPI: Inferred from physical interaction	16014375	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in apoptotic cell clearance	IGI IGI: Inferred from genetic interaction	20826760	MGI
acts upstream of or within blood coagulation, fibrin clot formation	IMP IMP: Inferred from mutant phenotype	28576878	MGI
acts upstream of or within cell-matrix adhesion	IGI IGI: Inferred from genetic interaction	17099249	MGI
acts upstream of or within cell-substrate junction assembly	IDA IDA: Inferred from direct assay	12867986	MGI
acts upstream of or within cellular response to platelet-derived growth factor stimulus	IMP IMP: Inferred from mutant phenotype	22984613	MGI
acts upstream of or within platelet aggregation	IMP IMP: Inferred from mutant phenotype	28576878	MGI
acts upstream of or within platelet-derived growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	22984613	MGI
involved in positive regulation of T cell migration	IDA IDA: Inferred from direct assay	21670307	MGI
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	20675382	MGI
acts upstream of or within positive regulation of cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	22984613	MGI
acts upstream of or within positive regulation of fibroblast migration	IMP IMP: Inferred from mutant phenotype	22984613	MGI
acts upstream of or within positive regulation of fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	22984613	MGI
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	25911094	MGI
involved in positive regulation of osteoblast proliferation	IMP IMP: Inferred from mutant phenotype	20675382	MGI
acts upstream of or within positive regulation of substrate adhesion-dependent cell spreading	IMP IMP: Inferred from mutant phenotype	22984613	MGI
involved in regulation of actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	25911094	MGI
acts upstream of or within regulation of extracellular matrix organization	IMP IMP: Inferred from mutant phenotype	22984613	MGI
involved in regulation of protein localization	IMP IMP: Inferred from mutant phenotype	29038237	MGI
acts upstream of or within regulation of protein tyrosine kinase activity	IMP IMP: Inferred from mutant phenotype	22984613	MGI
involved in regulation of serotonin uptake	IMP IMP: Inferred from mutant phenotype	29038237	MGI
acts upstream of or within regulation of trophoblast cell migration	IMP IMP: Inferred from mutant phenotype	15031111	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of alpha9-beta1 integrin-ADAM8 complex	IDA IDA: Inferred from direct assay	16995821	MGI
part of alphav-beta3 integrin-PKCalpha complex	IDA IDA: Inferred from direct assay	16014375	MGI
located in apical plasma membrane	IDA IDA: Inferred from direct assay	16216233	MGI
located in cell surface	IDA IDA: Inferred from direct assay	21670307	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	9553049	MGI
located in focal adhesion	IDA IDA: Inferred from direct assay	29038237	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	16467530	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	16467530	MGI
located in synapse	IDA IDA: Inferred from direct assay	29038237	MGI
is active in synaptic membrane	IDA IDA: Inferred from direct assay	16467530	MGI
is active in synaptic membrane	IEP IEP: Inferred from expression pattern	16467530	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

integrin beta-3

GPIIIa	platelet glycoprotein IIIa (GP3A)
platelet gpIIIa	platelet membrane glycoprotein IIIa

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06966	ITGB3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06967	ITGB3BP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Itgb3	NCBI	NCBI:3690
Macaca fascicularis	Itgb3	NCBI	NCBI:102117791

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