Jag1 - jagged 1 Gene

Mus musculus

Also known as Htu; Ozz; ABE2; Ser-1; Gena228; Gsfabe2

Gene ID: 16449 | Gene type: protein coding

About Jag1

Summary

Enables Notch binding activity. Involved in several processes, including circulatory system development; glomerular visceral epithelial cell development; and positive regulation of Notch signaling pathway. Acts upstream of or within several processes, including animal organ development; negative regulation of cell differentiation; and positive regulation of cell differentiation. Located in adherens junction and apical plasma membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Used to study Alagille syndrome. Human ortholog(s) of this gene implicated in Alagille syndrome; congenital heart disease; multiple sclerosis; and tetralogy of Fallot. Orthologous to human JAG1 (jagged canonical Notch ligand 1). [provided by Alliance of Genome Resources, Apr 2022]

Jag1 Products(1)

mRNA	Protein	Name
NM_013822.5	NP_038850.1	protein jagged-1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables Notch binding	IPI IPI: Inferred from physical interaction	10551863	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15574878	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Notch signaling pathway	IDA IDA: Inferred from direct assay	15574878	MGI
acts upstream of or within Notch signaling pathway	IGI IGI: Inferred from genetic interaction	25406395	MGI
involved in Notch signaling pathway	IMP IMP: Inferred from mutant phenotype	19509466	MGI
acts upstream of or within animal organ morphogenesis	IMP IMP: Inferred from mutant phenotype	11181574	MGI
involved in aorta morphogenesis	IMP IMP: Inferred from mutant phenotype	19509466	MGI
acts upstream of or within blood vessel remodeling	IMP IMP: Inferred from mutant phenotype	10196361	MGI
acts upstream of or within camera-type eye development	IMP IMP: Inferred from mutant phenotype	10196361	MGI
involved in cardiac neural crest cell development involved in outflow tract morphogenesis	IMP IMP: Inferred from mutant phenotype	19509466	MGI
involved in cardiac right ventricle morphogenesis	IMP IMP: Inferred from mutant phenotype	19509466	MGI
involved in cardiac septum morphogenesis	IMP IMP: Inferred from mutant phenotype	19509466	MGI
acts upstream of or within ciliary body morphogenesis	IMP IMP: Inferred from mutant phenotype	23676271	MGI
involved in distal tubule development	IEP IEP: Inferred from expression pattern	15821257	MGI
involved in endocardial cushion cell development	IMP IMP: Inferred from mutant phenotype	19509466	MGI
acts upstream of or within inhibition of neuroepithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	15064243	MGI
acts upstream of or within inner ear auditory receptor cell differentiation	IMP IMP: Inferred from mutant phenotype	16495313	MGI
involved in inner ear development	IMP IMP: Inferred from mutant phenotype	19389353	MGI
involved in loop of Henle development	IEP IEP: Inferred from expression pattern	15821257	MGI
acts upstream of or within morphogenesis of an epithelial sheet	IMP IMP: Inferred from mutant phenotype	11861489	MGI
involved in negative regulation of endothelial cell differentiation	IDA IDA: Inferred from direct assay	25535084	MGI
acts upstream of or within negative regulation of fat cell differentiation	IDA IDA: Inferred from direct assay	15060169	MGI
acts upstream of or within negative regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	15064243	MGI
involved in nephron development	IMP IMP: Inferred from mutant phenotype	23806616	MGI
acts upstream of neuroendocrine cell differentiation	IMP IMP: Inferred from mutant phenotype	15064243	MGI
acts upstream of neuron differentiation	IMP IMP: Inferred from mutant phenotype	20081190	MGI
involved in podocyte development	IMP IMP: Inferred from mutant phenotype	23806616	MGI
involved in positive regulation of Notch signaling pathway	IDA IDA: Inferred from direct assay	10958687	MGI
acts upstream of or within positive regulation of myeloid cell differentiation	IDA IDA: Inferred from direct assay	15845452	MGI
acts upstream of or within positive regulation of osteoblast differentiation	IDA IDA: Inferred from direct assay	23980096	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	19509466	MGI
acts upstream of or within regulation of epithelial cell proliferation	IGI IGI: Inferred from genetic interaction	25406395	MGI
involved in response to muramyl dipeptide	IDA IDA: Inferred from direct assay	21156799	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in adherens junction	IDA IDA: Inferred from direct assay	24715457	MGI
located in apical part of cell	IDA IDA: Inferred from direct assay	15821257	MGI
located in apical plasma membrane	IDA IDA: Inferred from direct assay	24715457	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	16000382	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein jagged-1

Serrate-1

Recombinant Jag1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71633	Jagged-1/JAG1 Protein, Mouse (Myc, His-SUMO)	Q9QXX0 (G33-E334)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1846A	Jagged-1 (188-204) (TFA)	Agonist	99.89%	Unkown
HY-P1846	Jagged-1 (188-204)	Agonist	/	Unkown
HY-RS07012	JAG1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Jag1	NCBI	NCBI:182

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