1. Gene
  2. DDOST - dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit Gene

DDOST - dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit Gene

Homo sapiens

Also known as OST; WBP1; AGER1; CDG1R; GATD6; OST48; OKSWcl45

Gene ID: 1650 | Gene type: protein coding

About DDOST

Cytogenetic location: 1p36.12 Genomic coordinates (GRCh38): 1:20,651,777-20,661,369 (from NCBI)

This gene has 5 transcripts (splice variants), 204 orthologues and is associated with 3 phenotypes. Ubiquitous expression in thyroid (RPKM 112.6), placenta (RPKM 100.3) and 25 other tissues.

Summary

This gene encodes a component of the oligosaccharyltransferase complex which catalyzes the transfer of high-mannose oligosaccharides to asparagine residues on nascent polypeptides in the lumen of the rough endoplasmic reticulum. The protein complex co-purifies with ribosomes. The product of this gene is also implicated in the processing of advanced glycation endproducts (AGEs), which form from non-enzymatic reactions between sugars and proteins or lipids and are associated with aging and hyperglycemia. [provided by RefSeq, Jul 2008]

DDOST Products(1)

mRNA Protein Name
NM_005216.5 NP_005207.3 dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit precursor

DDOST Protein Structure

DDOST_48kD

DDOST_48kD: Oligosaccharyltransferase 48 kDa subunit beta (47 - 454)

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  • 456 a.a.
Protein Preferred Names Protein Names

dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

advanced glycation end-product receptor 1

Recombinant DDOST Proteins

Cat. No. Product Name Accession Purity
HY-P75701 DDOST Protein, Human P39656-1 (S43-P427) ≥95%

Related Diseases

Diseases Alias
Congenital Disorder Of Glycosylation, Type Ir

Congenital Disorder Of Glycosylation Type Ir

CDG1R

Cdg Ir

Cdgir

Congenital Disorder Of Glycosylation 1r

Cdg-Ir

Congenital Disorder Of Glycosylation Ir

Ddost-Cdg

Cdg Syndrome Type Ir

Carbohydrate Deficient Glycoprotein Syndrome Type Ir

Congenital Disorder Of Glycosylation Type 1r

Glycosylation, Congenital Disorder Of, Type Ir

Congenital Disorder Of Glycosylation, Type In

Congenital Disorder Of Glycosylation

CDG1N

Congenital Disorders Of Glycosylation

Cdg In

Cdgin

Congenital Disorder Of Glycosylation 1n

Carbohydrate-Deficient Glycoprotein Syndrome

Cdg

Rft1-Cdg

Cdg-In

Congenital Disorder Of Glycosylation Type In

Carbohydrate Deficient Glycoprotein Syndrome

Cdg Syndrome

Congenital Disorder Of Glycosylation In

Carbohydrate-Deficient Glycoprotein Syndromes

Cdg Syndrome Type In

Carbohydrate Deficient Glycoprotein Syndrome Type In

Congenital Disorder Of Glycosylation Type 1n

Man5glcnac2-Pp-Dol Flippase Deficiency

Glycosylation, Congenital Disorder Of

Glycosylation, Congenital Disorder Of, Type In

Granulomatous Disease, Chronic, Autosomal Recessive, 2

Chronic Granulomatous Disease Due To Deficiency Of Ncf-2

CGD2

Ncf2 Deficiency

P67-Phox Deficiency

Autosomal Recessive Chronic Granulomatous Disease Cytochrome B-Positive Type Ii

Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type 2

Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type Ii

Cgd, Autosomal Recessive Cytochrome B-Positive, Type Ii

Granulomatous Disease, Chronic, Due To Ncf2 Deficiency

Neutrophil Cytosol Factor 2 Deficiency

Chronic Granulomatous Disease 2, Autosomal Recessive

Autosomal Recessive Chronic Granulomatous Disease 2

Cdg2

Deficiency Of Ncf2

Deficiency Of P67-Phox

Chronic Granulomatous Disease Autosomal Recessive Cytochrome B-Positive Type Ii

Deficiency Of Neutrophil Cytosol Factor 2

Avellino Corneal Dystrophy

Immunodeficiency 47

Congenital Disorder Of Glycosylation Type Ii

CDG2E

Congenital Disorder Of Glycosylation Type Iie

IMD47

Cdg2s

Cdg Iis

Cdgiis

Immunodeficiency And Hepatopathy With Or Without Neurologic Features

Congenital Disorder Of Glycosylation, Type Ii

CDG1I

Congenital Disorder Of Glycosylation, Type Iie

Cdg Iie

Congenital Disorder Of Glycosylation Type 2e

Congenital Disorder Of Glycosylation, Type Iis

Cdg Ii

Cdgii

Cdgiie

Carbohydrate Deficient Glycoprotein Syndrome Type Iie

Cdg Syndrome Type Iie

Congenital Disorder Of Glycosylation Ii

Congenital Disorder Of Glycosylation 1i

Cdg-Iie

Alg2-Cdg

Cdg-Ii

Glycosylation, Congenital Disorder Of, Type Ii

Cdgiide

Congenital Disorder Of Glycosylation Type Iis

Cog7-Cdg

Cdg Syndrome Type Ii

Carbohydrate Deficient Glycoprotein Syndrome Type Ii

Congenital Disorder Of Glycosylation Type 1i

Mannosyltransferase 2 Deficiency

Congenital Disorder Of Glycosylation 2e

Congenital Disorder Of Glycosylation 2s

Congenital Disorders Of Glycosylation Type Ii

Glycosylation, Congenital Disorder Of, Type Iie

Immunodeficiency, Type 47

Congenital Disorder Of Glycosylation Type 2a

Autosomal Recessive Intellectual Developmental Disorder

Mental Retardation, Autosomal Recessive

Autosomal Recessive Mental Retardation

Autosomal Recessive Non-Syndromic Mental Retardation

Autosomal Recessive Non-Syndromic Intellectual Disability

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus DDOST MGD MGI:1194508
Macaca mulatta DDOST VGNC VGNC:71757
Bos taurus DDOST VGNC VGNC:27952
Felis catus DDOST VGNC VGNC:61394
Rattus norvegicus DDOST RGD RGD:1308970
Canis familiaris DDOST VGNC VGNC:39841
Others DDOST NCBI