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  2. DDT - D-dopachrome tautomerase Gene

DDT - D-dopachrome tautomerase Gene

Homo sapiens

Also known as D-DT; DDCT; MIF2; MIF-2

Gene ID: 1652 | Gene type: protein coding

About DDT

Cytogenetic location: 22q11.23 Genomic coordinates (GRCh38): 22:23,971,370-23,980,504 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 174 orthologues and 2 paralogues. Broad expression in liver (RPKM 108.4), kidney (RPKM 65.2) and 23 other tissues.

Summary

D-dopachrome tautomerase converts D-dopachrome into 5,6-dihydroxyindole. The DDT gene is related to the migration inhibitory factor (MIF) in terms of sequence, Enzyme activity, and gene structure. DDT and MIF are closely linked on chromosome 22. [provided by RefSeq, Jul 2008]

DDT Products(4)

mRNA Protein Name
NM_001084392.3 NP_001077861.1 D-dopachrome decarboxylase isoform a
NM_001355.4 NP_001346.1 D-dopachrome decarboxylase isoform a
NM_001381852.2 NP_001368781.1 D-dopachrome decarboxylase isoform b
NM_001397485.1 NP_001384414.1 D-dopachrome decarboxylase isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables D-dopachrome decarboxylase activity IDA
IDA: Inferred from direct assay
8267597 GOA
enables D-dopachrome decarboxylase activity IMP
IMP: Inferred from mutant phenotype
9480844 GOA
enables cytokine receptor binding IDA
IDA: Inferred from direct assay
21817065 GOA
enables phenylpyruvate tautomerase activity IDA
IDA: Inferred from direct assay
21817065 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of macrophage chemotaxis IDA
IDA: Inferred from direct assay
21817065 GOA
involved in positive regulation of ERK1 and ERK2 cascade IGI
IGI: Inferred from genetic interaction
21817065 GOA
involved in positive regulation of tumor necrosis factor production IDA
IDA: Inferred from direct assay
21817065 GOA
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
21817065 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DDT Protein Structure

MIF

MIF: Macrophage migration inhibitory factor (MIF) (2 - 116)

  • 0
  • 100
  • 118 a.a.
Protein Preferred Names Protein Names

D-dopachrome decarboxylase

phenylpyruvate tautomerase II

Orthologs Information

Species Symbol Source ID
Rattus norvegicus DDT RGD RGD:61923
Mus musculus DDT MGD MGI:1298381
Canis familiaris DDT NCBI NCBI:100856501
Macaca fascicularis DDT NCBI NCBI:102140262
Others DDT NCBI