2. Gene
  3. DDX10 - DEAD-box helicase 10 Gene

DDX10 - DEAD-box helicase 10 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as Dbp4; HRH-J8

Gene ID: 1662 | Gene type: protein coding

About DDX10

Cytogenetic location: 11q22.3 Genomic coordinates (GRCh38): 11:108,665,069-108,940,927 (from NCBI)

This gene has 21 transcripts (splice variants), 199 orthologues, 38 paralogues and is associated with 72 phenotypes. Ubiquitous expression in testis (RPKM 11.2), kidney (RPKM 9.3) and 25 other tissues.

Summary

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it may be involved in ribosome assembly. Fusion of this gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. [provided by RefSeq, Jul 2008]

DDX10 Products(1)

mRNA Protein Name
NM_004398.4 NP_004389.2 probable ATP-dependent RNA helicase DDX10

DDX10 Protein Structure

DEAD

DEAD: DEAD/DEAH box helicase (93 - 263)

Helicase_C

Helicase_C: Helicase conserved C-terminal domain (338 - 409)

DUF4217

DUF4217: Domain of unknown function (DUF4217) (449 - 512)

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  • 875 a.a.
Protein Preferred Names Protein Names

probable ATP-dependent RNA helicase DDX10

DDX10-NUP98 fusion protein type 2

Related Diseases

Diseases Alias
Myelodysplastic Syndrome

Myelodysplastic Syndromes

Myelodysplasia

MDS

Myelodysplastic Syndrome Included

Myelodysplastic Syndrome, Susceptibility To, Included

Myelodysplastic Syndrome, Somatic

Myelodysplastic Syndrome, Susceptibility To
Paralytic Squint

Paralytic Strabismus

Incomitant Dissociation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03630 DDX10 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus DDX10 VGNC VGNC:27956
Rattus norvegicus DDX10 RGD RGD:1308990
Canis familiaris DDX10 VGNC VGNC:39845
Macaca mulatta DDX10 VGNC VGNC:100922
Mus musculus DDX10 MGD MGI:1924841
Felis catus DDX10 VGNC VGNC:61397