Kpna1 - karyopherin (importin) alpha 1 Gene

Mus musculus

Also known as NPI1; Rch2; IPOA5; mSRP1

Gene ID: 16646 | Gene type: protein coding

About Kpna1

Summary

Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Involved in postsynapse to nucleus signaling pathway. Acts upstream of or within several processes, including NLS-bearing protein import into nucleus; satellite cell activation involved in skeletal muscle regeneration; and skeletal muscle satellite cell proliferation. Is active in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including central nervous system; genitourinary system; gut; integumental system; and sensory organ. Orthologous to human KPNA1 (karyopherin subunit alpha 1). [provided by Alliance of Genome Resources, Apr 2022]

Kpna1 Products(1)

mRNA	Protein	Name
NM_008465.5	NP_032491.2	importin subunit alpha-5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18716025	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within NLS-bearing protein import into nucleus	IMP IMP: Inferred from mutant phenotype	27434733	MGI
involved in postsynapse to nucleus signaling pathway	IDA IDA: Inferred from direct assay	15603742	MGI
acts upstream of or within regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	27434733	MGI
acts upstream of or within regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	27434733	MGI
acts upstream of or within satellite cell activation involved in skeletal muscle regeneration	IMP IMP: Inferred from mutant phenotype	27434733	MGI
acts upstream of or within skeletal muscle satellite cell proliferation	IMP IMP: Inferred from mutant phenotype	27434733	MGI
acts upstream of or within skeletal muscle tissue regeneration	IMP IMP: Inferred from mutant phenotype	27434733	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	15603742	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	15603742	MGI
is active in postsynaptic density	IDA IDA: Inferred from direct assay	15603742	MGI
is active in postsynaptic density	IEP IEP: Inferred from expression pattern	15603742	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

importin subunit alpha-5

NPI-1	RAG cohort protein 2
SRP1-beta	importin alpha 5
importin alpha-S1	importin subunit alpha-1
karyopherin subunit alpha-1	m-importin-alpha-S1
nucleoprotein interactor 1

Kpna1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Kpna1	Q60960	SF1	Homo sapiens	Q15637	Y2H Fragment Pooling	26420826

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07415	KPNA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kpna1	NCBI	NCBI:3836

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