RASSF6 - Ras association domain family member 6 Gene

Homo sapiens

Gene ID: 166824 | Gene type: protein coding

About RASSF6

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:73,571,550-73,620,631 (from NCBI)

This gene has 5 transcripts (splice variants), 196 orthologues and 5 paralogues. Broad expression in stomach (RPKM 5.6), colon (RPKM 3.3) and 15 other tissues.

Summary

This gene encodes a member of the Ras-association domain family (RASSF). Members of this family form the core of a highly conserved tumor suppressor network, the Salvador-Warts-Hippo (SWH) pathway. The protein encoded by this gene is a Ras effector protein that induces Apoptosis. A genomic region containing this gene has been linked to susceptibility to viral bronchiolitis. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]

RASSF6 Products(4)

mRNA	Protein	Name
NM_001270391.2	NP_001257320.1	ras association domain-containing protein 6 isoform c
NM_001270392.1	NP_001257321.1	ras association domain-containing protein 6 isoform d
NM_177532.5	NP_803876.1	ras association domain-containing protein 6 isoform a
NM_201431.2	NP_958834.1	ras association domain-containing protein 6 isoform b

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20920251	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RASSF6 Protein Structure

0
100
200
300
369 a.a.

Protein Preferred Names

Protein Names

ras association domain-containing protein 6

Ras association (RalGDS/AF-6) domain family 6

RASSF6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RASSF6	Q6ZTQ3	STK4	Homo sapiens	Q13043	Anti Tag CoIP	33961781
Intra	RASSF6	Q6ZTQ3	STK4	Homo sapiens	Q13043	Anti Tag CoIP	24366813
Intra	RASSF6	Q6ZTQ3	STK4	Homo sapiens	Q13043	Y2H	20920251
Intra	RASSF6	Q6ZTQ3	STK3	Homo sapiens	Q13188	Anti Tag CoIP	24366813
Intra	RASSF6	Q6ZTQ3	STK3	Homo sapiens	Q13188	Y2H	20920251
Intra	RASSF6	Q6ZTQ3	STK3	Homo sapiens	Q13188	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Bronchiolitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11706	RASSF6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RASSF6	RGD	RGD:1566082
Felis catus	RASSF6	VGNC	VGNC:64509
Mus musculus	RASSF6	MGD	MGI:1920496
Macaca mulatta	RASSF6	VGNC	VGNC:76515
Canis familiaris	RASSF6	VGNC	VGNC:45383
Bos taurus	RASSF6	VGNC	VGNC:33762

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