2. Gene
  3. TENT2 - terminal nucleotidyltransferase 2 Gene

TENT2 - terminal nucleotidyltransferase 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as APD4; GLD2; TUT2; PAPD4

Gene ID: 167153 | Gene type: protein coding

About TENT2

Cytogenetic location: 5q14.1 Genomic coordinates (GRCh38): 5:79,612,441-79,688,246 (from NCBI)

This gene has 17 transcripts (splice variants), 202 orthologues and 4 paralogues. Ubiquitous expression in bone marrow (RPKM 14.6), lymph node (RPKM 12.6) and 25 other tissues.

Summary

Enables 5'-3' RNA polymerase activity and polynucleotide adenylyltransferase activity. Involved in RNA metabolic process and negative regulation of RNA catabolic process. Predicted to be located in nucleus. Predicted to be part of nuclear RNA-directed RNA polymerase complex. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

TENT2 Products(56)

mRNA Protein Name
NM_001114393.3 NP_001107865.1 poly(A) RNA polymerase GLD2 isoform 1
NM_001114394.3 NP_001107866.1 poly(A) RNA polymerase GLD2 isoform 1
NM_001297744.3 NP_001284673.1 poly(A) RNA polymerase GLD2 isoform 2
NM_001297745.3 NP_001284674.1 poly(A) RNA polymerase GLD2 isoform 3
NM_001349548.2 NP_001336477.1 poly(A) RNA polymerase GLD2 isoform 4
NM_001349549.2 NP_001336478.1 poly(A) RNA polymerase GLD2 isoform 5
NM_001349550.2 NP_001336479.1 poly(A) RNA polymerase GLD2 isoform 5
NM_001349551.2 NP_001336480.1 poly(A) RNA polymerase GLD2 isoform 6
NM_001349552.2 NP_001336481.1 poly(A) RNA polymerase GLD2 isoform 1
NM_001349553.2 NP_001336482.1 poly(A) RNA polymerase GLD2 isoform 1
NM_001349554.2 NP_001336483.1 poly(A) RNA polymerase GLD2 isoform 2
NM_001388093.1 NP_001375022.1 poly(A) RNA polymerase GLD2 isoform 5
NM_001388094.1 NP_001375023.1 poly(A) RNA polymerase GLD2 isoform 5
NM_001388095.1 NP_001375024.1 poly(A) RNA polymerase GLD2 isoform 6
NM_001388096.1 NP_001375025.1 poly(A) RNA polymerase GLD2 isoform 6
NM_001388097.1 NP_001375026.1 poly(A) RNA polymerase GLD2 isoform 6
NM_001388098.1 NP_001375027.1 poly(A) RNA polymerase GLD2 isoform 7
NM_001388099.1 NP_001375028.1 poly(A) RNA polymerase GLD2 isoform 8
NM_001388100.1 NP_001375029.1 poly(A) RNA polymerase GLD2 isoform 8
NM_001388101.1 NP_001375030.1 poly(A) RNA polymerase GLD2 isoform 9
NM_001388102.1 NP_001375031.1 poly(A) RNA polymerase GLD2 isoform 1
NM_001388103.1 NP_001375032.1 poly(A) RNA polymerase GLD2 isoform 1
NM_001388105.1 NP_001375034.1 poly(A) RNA polymerase GLD2 isoform 1
NM_001388106.1 NP_001375035.1 poly(A) RNA polymerase GLD2 isoform 1
NM_001388107.1 NP_001375036.1 poly(A) RNA polymerase GLD2 isoform 1
NM_001388108.1 NP_001375037.1 poly(A) RNA polymerase GLD2 isoform 1
NM_001388109.1 NP_001375038.1 poly(A) RNA polymerase GLD2 isoform 1
NM_001388110.1 NP_001375039.1 poly(A) RNA polymerase GLD2 isoform 1
NM_001388111.1 NP_001375040.1 poly(A) RNA polymerase GLD2 isoform 1
NM_001388112.1 NP_001375041.1 poly(A) RNA polymerase GLD2 isoform 1
NM_001388113.1 NP_001375042.1 poly(A) RNA polymerase GLD2 isoform 16
NM_001388114.1 NP_001375043.1 poly(A) RNA polymerase GLD2 isoform 2
NM_001388115.1 NP_001375044.1 poly(A) RNA polymerase GLD2 isoform 2
NM_001388116.1 NP_001375045.1 poly(A) RNA polymerase GLD2 isoform 2
NM_001388117.1 NP_001375046.1 poly(A) RNA polymerase GLD2 isoform 2
NM_001388118.1 NP_001375047.1 poly(A) RNA polymerase GLD2 isoform 2
NM_001388119.1 NP_001375048.1 poly(A) RNA polymerase GLD2 isoform 2
NM_001388120.1 NP_001375049.1 poly(A) RNA polymerase GLD2 isoform 2
NM_001388121.1 NP_001375050.1 poly(A) RNA polymerase GLD2 isoform 2
NM_001388122.1 NP_001375051.1 poly(A) RNA polymerase GLD2 isoform 2
NM_001388123.1 NP_001375052.1 poly(A) RNA polymerase GLD2 isoform 2
NM_001388124.1 NP_001375053.1 poly(A) RNA polymerase GLD2 isoform 2
NM_001388125.1 NP_001375054.1 poly(A) RNA polymerase GLD2 isoform 2
NM_001388126.1 NP_001375055.1 poly(A) RNA polymerase GLD2 isoform 2
NM_001388127.1 NP_001375056.1 poly(A) RNA polymerase GLD2 isoform 2
NM_001388128.1 NP_001375057.1 poly(A) RNA polymerase GLD2 isoform 2
NM_001388129.1 NP_001375058.1 poly(A) RNA polymerase GLD2 isoform 2
NM_001388130.1 NP_001375059.1 poly(A) RNA polymerase GLD2 isoform 10
NM_001388131.1 NP_001375060.1 poly(A) RNA polymerase GLD2 isoform 11
NM_001388132.1 NP_001375061.1 poly(A) RNA polymerase GLD2 isoform 12
NM_001388133.1 NP_001375062.1 poly(A) RNA polymerase GLD2 isoform 3
NM_001388134.1 NP_001375063.1 poly(A) RNA polymerase GLD2 isoform 13
NM_001388135.1 NP_001375064.1 poly(A) RNA polymerase GLD2 isoform 13
NM_001388136.1 NP_001375065.1 poly(A) RNA polymerase GLD2 isoform 14
NM_001388137.1 NP_001375066.1 poly(A) RNA polymerase GLD2 isoform 15
NM_173797.5 NP_776158.2 poly(A) RNA polymerase GLD2 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables poly(A) RNA polymerase activity IDA
IDA: Inferred from direct assay
15070731 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence Reference Source
involved in histone mRNA catabolic process IMP
IMP: Inferred from mutant phenotype
18172165 GOA
involved in mRNA 3'-end processing IDA
IDA: Inferred from direct assay
15070731 GOA
involved in negative regulation of miRNA catabolic process IDA
IDA: Inferred from direct assay
23200856 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TENT2 Protein Structure

PAP_assoc

PAP_assoc: Cid1 family poly A polymerase (386 - 440)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 484 a.a.
Protein Preferred Names Protein Names

poly(A) RNA polymerase GLD2

PAP associated domain containing 4

TENT2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
TENT2 Q6PIY7 CADPS Homo sapiens A2RRN7
Y2H Prey Pooling
32296183
Intra
TENT2 Q6PIY7 CADPS Homo sapiens A2RRN7
Y2H Array
32296183
Intra
TENT2 Q6PIY7 KRTAP6-3 Homo sapiens Q3LI67
Y2H Array
32296183
Intra
TENT2 Q6PIY7 KRTAP6-3 Homo sapiens Q3LI67
Y2H Prey Pooling
32296183
Intra
TENT2 Q6PIY7 CALCOCO2 Homo sapiens Q13137
Validated Y2H
25416956
Intra
TENT2 Q6PIY7 RBPMS Homo sapiens Q93062
Y2H Array
25416956
Intra
TENT2 Q6PIY7 RBPMS Homo sapiens Q93062
Y2H Prey Pooling
25416956
Intra
TENT2 Q6PIY7 DTX2 Homo sapiens Q86UW9
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Trichothiodystrophy 1, Photosensitive

TTD1

Tay Syndrome

Trichothiodystrophy With Congenital Ichthyosis

Photosensitive Trichothiodystrophy

Ibids Syndrome

Ttdp

Ichthyosiform Erythroderma With Hair Abnormality And Mental And Growth Retardation

Ichthyosis, Congenital, With Trichothiodystrophy

Pibids Syndrome

Photosensitive Trichothiodystrophy 1

Trichothiodystrophy, Photosensitive

Sulfur-Deficient Brittle Hair Syndrome

Ttd-P

Ichthyosis With Brittle Hair, Intellectual Impairment, Decreased Fertility And Short Stature

Trichothiodystrophy Photosensitive

Trichothiodystrophy, Type 1

Tricho-Thiodystrophy Disorder

Trichothiodystrophy Syndromes

Amish Brittle Hair Brain Syndrome
Trichothiodystrophy 6, Nonphotosensitive

TTD6

Nonphotosensitive Trichothiodystrophy 6

Trichothiodystrophy 6, Non-Photosensitive
Nonphotosensitive Trichothiodystrophy

Trichothiodystrophy Nonphotosensitive

Amish Brittle Hair Brain Syndrome
Perlman Syndrome

Nephroblastomatosis, Fetal Ascites, Macrosomia And Wilms Tumor

PRLMNS

Renal Hamartomas, Nephroblastomatosis, And Fetal Gigantism

Nephroblastomatosis Fetal Ascites Macrosomia And Wilms Tumor

Nephroblastomatosis, Fetal Ascites, Macrosomia, And Wilms Tumor

Nephroblastomatosis - Fetal Ascites - Macrosomia - Wilms Tumor

Renal Hamartomas, Nephroblastomatosis And Fetal Gigantism

Nephroblastomatosis-Fetal Ascites-Macrosomia-Wilms Tumor Syndrome

Renal Hamartomas Nephroblastomatosis And Fetal Gigantism

Nephroblastoma

Fetal Macrosomia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14366 TENT2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TENT2 VGNC VGNC:53194
Macaca mulatta TENT2 VGNC VGNC:79637
Mus musculus TENT2 MGD MGI:2140950
Felis catus TENT2 VGNC VGNC:66073
Rattus norvegicus TENT2 RGD RGD:1306438
Bos taurus TENT2 VGNC VGNC:54564