RBPMS - RNA binding protein, mRNA processing factor Gene

Homo sapiens

Also known as HERMES

Gene ID: 11030 | Gene type: protein coding

About RBPMS

Cytogenetic location: 8p12 Genomic coordinates (GRCh38): 8:30,384,541-30,572,256 (from NCBI)

This gene has 20 transcripts (splice variants), 194 orthologues and 1 paralogue. Ubiquitous expression in prostate (RPKM 14.5), ovary (RPKM 13.7) and 23 other tissues.

Summary

This gene encodes a member of the RNA recognition motif family of RNA-binding proteins. The RNA recognition motif is between 80-100 Amino acids in length and family members contain one to four copies of the motif. The RNA recognition motif consists of two short stretches of conserved sequence, as well as a few highly conserved hydrophobic residues. The encoded protein has a single, putative RNA recognition motif in its N-terminus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]

RBPMS Products(4)

mRNA	Protein	Name
NM_001008710.3	NP_001008710.1	RNA-binding protein with multiple splicing isoform A
NM_001008711.3	NP_001008711.1	RNA-binding protein with multiple splicing isoform B
NM_001008712.3	NP_001008712.1	RNA-binding protein with multiple splicing isoform C
NM_006867.4	NP_006858.1	RNA-binding protein with multiple splicing isoform A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA binding	IDA IDA: Inferred from direct assay	17099224	GOA
enables mRNA 3'-UTR binding	IDA IDA: Inferred from direct assay	24860013	GOA
enables mRNA CDS binding	IDA IDA: Inferred from direct assay	24860013	GOA
enables pre-mRNA intronic binding	IDA IDA: Inferred from direct assay	24860013	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	26347403	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	17099224	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in SMAD protein signal transduction	IDA IDA: Inferred from direct assay	17099224	GOA
involved in response to oxidative stress	IMP IMP: Inferred from mutant phenotype	26347403	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	17099224	GOA
located in cytoplasmic stress granule	IDA IDA: Inferred from direct assay	24860013	GOA
located in cytosol	IDA IDA: Inferred from direct assay	24860013	GOA
located in nucleus	IDA IDA: Inferred from direct assay	17099224	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RBPMS Protein Structure

RRM_1

0
100
196 a.a.

Protein Preferred Names

Protein Names

RNA-binding protein with multiple splicing

RNA binding protein with multiple splicing

Related Diseases

Diseases

Alias

Hordeolum

Stye	Boil Of Eyelid
Furuncle Of Eyelid	Hordeolum Externum

Retinal Ischemia

Acute Closed-Angle Glaucoma

Acute Angle-Closure Glaucoma

Optic Nerve Disease

Optic Neuropathy	Disorder Of The Second Nerve
Optic Nerve Disorder	Optic Nerve
Abnormality Of The Optic Nerve	Optic Nerve Disorders
Neuropathy, Optic	Disorder Of The Optic Nerve

Intraocular Pressure Quantitative Trait Locus

Glaucoma	IOPQTL
Glaucoma, Susceptibility To	Postinfectious Glaucoma
Glaucoma With Ocular Inflammation	Glaucoma Secondary To Eye Inflammation
Traumatic Glaucoma	Glaucoma With Concussion Of Globe
Glaucoma Due To Ocular Trauma	Glaucoma Associated With Ocular Trauma
Glaucoma Secondary To Drugs

Cranial Nerve Disease

Cranial Nerve Disorder	Disorder Of Cranial Nerve
Cranial Nerve Diseases

3-Methylglutaconic Aciduria, Type Iii

Optic Atrophy	3-Methylglutaconic Aciduria Type 3
Costeff Syndrome	Mga3
Costeff Optic Atrophy Syndrome	Optic Atrophy Plus Syndrome
Infantile Optic Atrophy With Chorea And Spastic Paraplegia	3-Methylglutaconic Aciduria Type Iii
Autosomal Recessive Optic Atrophy Plus Syndrome	Autosomal Recessive Optic Atrophy Type 3
Opa3 Defect	MGCA3
Mga, Type Iii	Iraqi Jewish Optic Atrophy Plus
Mga Type Iii	Optic Atrophy, Infantile, With Chorea And Spastic Paraplegia
Iraqi-Jewish 'Optic Atrophy Plus'	Optic Atrophy 3, Autosomal Recessive
Opa3, Autosomal Recessive	Opa3-Related 3-Methylglutaconic Aciduria
Iraqi-Jewish Optic Atrophy Plus	Atrophy Of Optic Disc
3-Alpha Methylglutaconic Aciduria Type Iii	Optic Atrophy 3
Optic Atrophy Infantile With Chorea And Spastic Paraplegia	Autosomal Recessive Opa3
Autosomal Recessive Optic Atrophy 3	3-Methylglutaconic Aciduria 3
3-Alpha-Methylglutaconic Aciduria Type 3	Optic Atrophy 3 Autosomal Recessive
Atrophy, Optic	Atrophy, Optic, Plus Syndrome
Optic Nerve Atrophy	Primary Optic Atrophy
Oa - [Optic Atrophy]	Second Cranial Nerve Atrophy
Second Cranium Nerve Atrophy

Glaucoma, Primary Open Angle

Glaucoma 1, Open Angle, E	Primary Open Angle Glaucoma
POAG	Adult-Onset Primary Open Angle Glaucoma
Chronic Simple Glaucoma	GLC1E
Primary Open Angle Glaucoma 1e	Glaucoma, Open Angle, Primary

Leber Hereditary Optic Neuropathy, Modifier Of

Leber Optic Atrophy	Leber Hereditary Optic Neuropathy
LHON	Leber'S Hereditary Optic Neuropathy
Leber Optic Atrophy, Susceptibility To	Leber'S Optic Atrophy
LOAM	Loas
Leber'S Disease	Leber'S Optic Neuropathy
Optic Atrophy, Hereditary, Leber	Lhon, Modifier Of
Optic Atrophy, Leber Type	Hereditary Optic Neuroretinopathy
Leber Hereditary Optic Atrophy	Loa
Optic Atrophy Leber Type	Leber Hereditary Optic Neuropathy, Modifier
Leber Hereditary Optic Neuropathy Susceptibility	Modifier Of Leber Hereditary Optic Neuropathy
Lebers Hereditary Optic Neuropathy	Leber Congenital Amaurosis

Eye Disease

Eye Diseases	Abnormality Of The Eye
Toxoplasma Oculopathy

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11774	RBPMS Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	RBPMS	VGNC	VGNC:45434
Macaca mulatta	RBPMS	VGNC	VGNC:76510
Rattus norvegicus	RBPMS	RGD	RGD:1561067
Felis catus	RBPMS	VGNC	VGNC:79987
Bos taurus	RBPMS	VGNC	VGNC:52815
Mus musculus	RBPMS	MGD	MGI:1334446

Name
Email *

	Sorry, but the email address you supplied was invalid.