Lag3 - lymphocyte-activation gene 3 Gene

Mus musculus

Also known as Ly66; CD223; LAG-3

Gene ID: 16768 | Gene type: protein coding

About Lag3

Summary

Enables MHC class II protein binding activity and transmembrane signaling receptor activity. Involved in negative regulation of regulatory T cell differentiation; plasmacytoid dendritic cell activation; and regulation of immune response. Acts upstream of or within cell surface receptor signaling pathway; negative regulation of interleukin-2 production; and positive regulation of natural killer cell mediated cytotoxicity. Located in external side of plasma membrane and extracellular region. Orthologous to human LAG3 (lymphocyte activating 3). [provided by Alliance of Genome Resources, Apr 2022]

Lag3 Products(1)

mRNA	Protein	Name
NM_008479.2	NP_032505.1	lymphocyte activation gene 3 protein precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables MHC class II protein binding	IDA IDA: Inferred from direct assay	12209638	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	30580966	MGI
enables transmembrane signaling receptor activity	IDA IDA: Inferred from direct assay	12209638	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of T cell activation	IDA IDA: Inferred from direct assay	12421911	MGI
acts upstream of or within cell surface receptor signaling pathway	IDA IDA: Inferred from direct assay	12421911	MGI
involved in cell surface receptor signaling pathway	IDA IDA: Inferred from direct assay	12209638	MGI
acts upstream of interleukin-2 production	IDA IDA: Inferred from direct assay	12421911	MGI
acts upstream of natural killer cell mediated cytotoxicity	IDA IDA: Inferred from direct assay	8602528	MGI
acts upstream of natural killer cell mediated cytotoxicity	IMP IMP: Inferred from mutant phenotype	8602528	MGI
acts upstream of or within negative regulation of T cell activation	IDA IDA: Inferred from direct assay	12421911	MGI
involved in negative regulation of T cell activation	IDA IDA: Inferred from direct assay	12209638	MGI
acts upstream of or within negative regulation of interleukin-2 production	IDA IDA: Inferred from direct assay	12421911	MGI
involved in negative regulation of regulatory T cell differentiation	IMP IMP: Inferred from mutant phenotype	15485628	MGI
involved in plasmacytoid dendritic cell activation	IMP IMP: Inferred from mutant phenotype	19201841	MGI
acts upstream of or within positive regulation of natural killer cell mediated cytotoxicity	IDA IDA: Inferred from direct assay	8602528	MGI
acts upstream of or within positive regulation of natural killer cell mediated cytotoxicity	IMP IMP: Inferred from mutant phenotype	8602528	MGI
involved in regulation of immune response	IDA IDA: Inferred from direct assay	30580966	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	8602528	MGI
located in extracellular region	IDA IDA: Inferred from direct assay	17245433	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

lymphocyte activation gene 3 protein

activation-induced cytidine deaminase-linked autoimmunity protein

aida

Lag3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Lag3	Q61790	Fgl1	Mus musculus	Q71KU9	BLI	30580966
Intra	Lag3	Q61790	Fgl1	Mus musculus	Q71KU9	Array	30580966
Cross	Lag3	Q61790	FGL1	Homo sapiens	Q08830	Array	30580966

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Lag3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73843	LAG-3 Protein, Mouse (HEK293, Fc)	Q61790/NP_032505.1 (S23-L442)	≥95%
HY-P73844	LAG-3 Protein, Mouse (HEK293)	Q61790 (G24-L442)	≥95%
HY-P78720	LAG-3 Protein, Mouse (419a.a, HEK293, His)	Q61790 (G24-L442)	≥95%

Related Agents

Clinical Phase

Inhibitory Antibodies (9)

Cat. No.	Product Name	Purity	Phase
HY-P99156	Relatlimab	97.56%	Phase 3
HY-P99573	Tebotelimab	99.52%	Phase 3
HY-P99617	Fianlimab	99.04%	Phase 3
HY-P99027	Ieramilimab	97.50%	Phase 2
HY-P99613	Favezelimab	97.79%	Phase 2
HY-P99933	Eftilagimod alfa	95.98%	Phase 2
HY-P990046	Tuparstobart	/	Phase 2
HY-P99736	Miptenalimab	/	Phase 2
HY-P99387	TSR-033	95.25%	Phase 1

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-144088	ZYF0033	Inhibitor	98.86%	Unkown
HY-162811	LAG-3 biner 1		/	Unkown
HY-145240	eIF4E-IN-1	Inhibitor	/	Unkown
HY-149916	A2AR-antagonist-1	Antagonist	/	Unkown
HY-RS07492	LAG3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-164308	SA-15-P	Inhibitor	/	Unkown

Inhibitory Antibodies (5)

Cat. No.	Product Name	Purity	Rare Diseases
HY-P99141	Anti-Mouse LAG-3 Antibody (C9B7W)	95.00%	Unkown
HY-P990700	Tobemstomig	/	Unkown
HY-P99354	Bavunalimab	/	Unkown
HY-P990740	Fanastomig	/	Unkown
HY-P990750	Negalstobart	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lag3	NCBI	NCBI:3902
Macaca fascicularis	Lag3	NCBI	NCBI:102122272

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