Lep - leptin Gene

Mus musculus

Also known as ob; obese

Gene ID: 16846 | Gene type: protein coding

About Lep

Summary

Enables DNA binding activity and growth factor activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of cytokine production; and positive regulation of signal transduction. Acts upstream of or within several processes, including Insulin secretion; monocarboxylic acid metabolic process; and regulation of Insulin secretion. Located in cytoplasm and extracellular space. Is expressed in several structures, including adipose tissue; alimentary system; central nervous system; early conceptus; and genitourinary system. Used to study abdominal obesity-metabolic syndrome (multiple); fatty liver disease (multiple); obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; congenital Leptin deficiency; liver disease (multiple); lung disease (multiple); and type 2 diabetes mellitus. Orthologous to human LEP (Leptin). [provided by Alliance of Genome Resources, Apr 2022]

Lep Products(1)

mRNA	Protein	Name
NM_008493.3	NP_032519.1	leptin precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	29519872	MGI
enables hormone activity	IDA IDA: Inferred from direct assay	36977414	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	24882746	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in T cell differentiation	IMP IMP: Inferred from mutant phenotype	9732873	MGI
acts upstream of or within adipose tissue development	IGI IGI: Inferred from genetic interaction	10742101	MGI
involved in adult feeding behavior	IDA IDA: Inferred from direct assay	9590691	MGI
acts upstream of or within aorta development	IMP IMP: Inferred from mutant phenotype	23413430	MGI
acts upstream of or within bile acid metabolic process	IDA IDA: Inferred from direct assay	12114517	MGI
involved in bone growth	IMP IMP: Inferred from mutant phenotype	10660043	MGI
involved in cell surface receptor signaling pathway via JAK-STAT	IDA IDA: Inferred from direct assay	21234744	MGI
acts upstream of or within cellular response to insulin stimulus	IDA IDA: Inferred from direct assay	29519872	MGI
acts upstream of or within central nervous system neuron development	IMP IMP: Inferred from mutant phenotype	10592285	MGI
acts upstream of or within cholesterol metabolic process	IGI IGI: Inferred from genetic interaction	15995171	MGI
acts upstream of or within determination of adult lifespan	IGI IGI: Inferred from genetic interaction	28069950	MGI
acts upstream of or within eating behavior	IGI IGI: Inferred from genetic interaction	10802666	MGI
acts upstream of or within elastin metabolic process	IMP IMP: Inferred from mutant phenotype	23413430	MGI
involved in energy homeostasis	IDA IDA: Inferred from direct assay	36977414	MGI
acts upstream of or within fatty acid beta-oxidation	IGI IGI: Inferred from genetic interaction	22958918	MGI
acts upstream of or within glucose homeostasis	IGI IGI: Inferred from genetic interaction	22958918	MGI
acts upstream of or within glucose metabolic process	IMP IMP: Inferred from mutant phenotype	12540600	MGI
acts upstream of or within hormone metabolic process	IMP IMP: Inferred from mutant phenotype	16513828	MGI
acts upstream of or within insulin secretion	IGI IGI: Inferred from genetic interaction	16141392	MGI
involved in leptin-mediated signaling pathway	IDA IDA: Inferred from direct assay	16825198	MGI
acts upstream of or within lipid metabolic process	IMP IMP: Inferred from mutant phenotype	12815040	MGI
involved in negative regulation of appetite	IDA IDA: Inferred from direct assay	9590691	MGI
involved in negative regulation of autophagy	IMP IMP: Inferred from mutant phenotype	25060689	MGI
involved in negative regulation of glucagon secretion	IDA IDA: Inferred from direct assay	21234744	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	21234744	MGI
involved in phagocytosis	IDA IDA: Inferred from direct assay	9438411	MGI
involved in positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	16825198	MGI
involved in positive regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	27986616	MGI
involved in positive regulation of interleukin-12 production	IDA IDA: Inferred from direct assay	9438411	MGI
involved in positive regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	9438411	MGI
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	16825198	MGI
involved in positive regulation of protein import into nucleus	IDA IDA: Inferred from direct assay	21234744	MGI
involved in positive regulation of receptor signaling pathway via JAK-STAT	IDA IDA: Inferred from direct assay	16825198	MGI
involved in positive regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	9438411	MGI
involved in regulation of bone remodeling	IMP IMP: Inferred from mutant phenotype	10660043	MGI
involved in regulation of brown fat cell differentiation	IDA IDA: Inferred from direct assay	20620997	MGI
acts upstream of or within regulation of catalytic activity	IMP IMP: Inferred from mutant phenotype	23413430	MGI
involved in regulation of cell cycle	IDA IDA: Inferred from direct assay	16825198	MGI
acts upstream of or within regulation of fat cell differentiation	IGI IGI: Inferred from genetic interaction	22927639	MGI
acts upstream of or within regulation of gluconeogenesis	IMP IMP: Inferred from mutant phenotype	16513828	MGI
acts upstream of or within regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	16513828	MGI
acts upstream of or within regulation of intestinal cholesterol absorption	IDA IDA: Inferred from direct assay	12114517	MGI
acts upstream of or within regulation of lipid biosynthetic process	IGI IGI: Inferred from genetic interaction	28069950	MGI
acts upstream of or within regulation of metabolic process	IMP IMP: Inferred from mutant phenotype	12925742	MGI
involved in regulation of nitric-oxide synthase activity	IDA IDA: Inferred from direct assay	15899045	MGI
acts upstream of or within regulation of protein localization to nucleus	IMP IMP: Inferred from mutant phenotype	20541607	MGI
acts upstream of or within regulation of steroid biosynthetic process	IMP IMP: Inferred from mutant phenotype	16513828	MGI
acts upstream of or within response to dietary excess	IGI IGI: Inferred from genetic interaction	12177191	MGI
acts upstream of or within response to dietary excess	IMP IMP: Inferred from mutant phenotype	16141392	MGI
acts upstream of or within response to insulin	IMP IMP: Inferred from mutant phenotype	16141392	MGI
involved in sexual reproduction	IMP IMP: Inferred from mutant phenotype	8589726	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11387233	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	9590691	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

leptin

obesity factor

Recombinant Lep Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70704	Leptin Protein, Mouse	Q544U0 (V22-C167)	≥95%
HY-P70704A	Leptin Protein, Mouse (His)	Q544U0 (V22-C167)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07593	LEP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lep	NCBI	NCBI:3952
Rattus norvegicus	Lep	NCBI	NCBI:25608

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