Lgals3 - lectin, galactose binding, soluble 3 Gene

Mus musculus

Also known as GBP; L-34; gal3; Mac-2

Gene ID: 16854 | Gene type: protein coding

About Lgals3

Summary

Predicted to enable several functions, including IgE binding activity; advanced glycation end-product receptor activity; and signaling receptor binding activity. Involved in negative regulation of T cell receptor signaling pathway; negative regulation of endocytosis; and negative regulation of lymphocyte activation. Acts upstream of or within extracellular matrix organization and skeletal system development. Located in several cellular components, including external side of plasma membrane; glial cell projection; and immunological synapse. Is expressed in several structures, including alimentary system; genitourinary system; respiratory system; skeleton; and skin. Used to study fatty liver disease. Human ortholog(s) of this gene implicated in asthma. Orthologous to human LGALS3 (Galectin 3). [provided by Alliance of Genome Resources, Apr 2022]

Lgals3 Products(2)

mRNA	Protein	Name
NM_001145953.1	NP_001139425.1	galectin-3
NM_010705.3	NP_034835.1	galectin-3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10745073	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within extracellular matrix organization	IGI IGI: Inferred from genetic interaction	15800063	MGI
NOT involved in maintenance of protein location	IDA IDA: Inferred from direct assay	21670307	MGI
involved in negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	IMP IMP: Inferred from mutant phenotype	19706535	MGI
involved in negative regulation of T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	19706535	MGI
involved in negative regulation of endocytosis	IMP IMP: Inferred from mutant phenotype	19706535	MGI
involved in negative regulation of immunological synapse formation	IMP IMP: Inferred from mutant phenotype	19706535	MGI
acts upstream of or within skeletal system development	IGI IGI: Inferred from genetic interaction	15800063	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	23576987	MGI
is active in cornified envelope	IDA IDA: Inferred from direct assay	26644517	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	10745073	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	23460747	MGI
located in extracellular matrix	IDA IDA: Inferred from direct assay	15800063	MGI
located in glial cell projection	IDA IDA: Inferred from direct assay	20826656	MGI
located in immunological synapse	IDA IDA: Inferred from direct assay	19706535	MGI
located in nucleus	IDA IDA: Inferred from direct assay	10745073	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

galectin-3

35 kDa lectin	CBP 35
L-34 galactoside-binding lectin	carbohydrate-binding protein 35
gal-3	galactose-specific lectin 3
igE-binding protein	laminin-binding protein
lectin L-29	mac-2 antigen

Recombinant Lgals3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77684	Galectin-3/LGALS3 Protein, Mouse (HEK293, His)	P16110 (A2-I264)	≥95%
HY-P79079	Galectin-3/LGALS3 Protein, Mouse	NP_034835.1 (A2-I264)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07604	LGALS3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS07605	LGALS3BP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lgals3	NCBI	NCBI:3958
Macaca fascicularis	Lgals3	NCBI	NCBI:102145569

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