2. Gene
  3. Lum - lumican Gene

Lum - lumican Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Ldc; SLRR2D

Gene ID: 17022 | Gene type: protein coding

About Lum

Summary

Predicted to enable collagen binding activity. Involved in positive regulation of transforming growth factor beta1 production. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in extracellular matrix. Is expressed in several structures, including alimentary system; ear; genitourinary system; heart and pericardium; and nervous system. Used to study Ehlers-Danlos syndrome classic type 1. Human ortholog(s) of this gene implicated in carotid artery disease; coronary artery disease; and pancreatic Cancer. Orthologous to human LUM (lumican). [provided by Alliance of Genome Resources, Apr 2022]

Lum Products(1)

mRNA Protein Name
NM_008524.2 NP_032550.2 lumican precursor
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15849191 MGI
involved in positive regulation of transforming growth factor beta1 production IMP
IMP: Inferred from mutant phenotype
21931815 MGI
Cellular Component GO Annotation Evidence Reference Source
located in extracellular matrix IDA
IDA: Inferred from direct assay
12128073 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lumican

KSPG lumican

keratan sulfate proteoglycan lumican

Recombinant Lum Proteins

Cat. No. Product Name Accession Purity
HY-P70370 Lumican/LUM Protein, Mouse (HEK293, His) P51885 (Q19-N338) ≥95%

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16747 Maralixibat chloride Inhibitor 99.08% Unkown
Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-101190 Volixibat / Phase 2
Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07891 LUM Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lum NCBI NCBI:4060
Susscrofa domestica Lum NCBI