LUM - lumican Gene

Homo sapiens

Also known as LDC; SLRR2D

Gene ID: 4060 | Gene type: protein coding

About LUM

Cytogenetic location: 12q21.33 Genomic coordinates (GRCh38): 12:91,102,629-91,111,494 (from NCBI)

This gene has 3 transcripts (splice variants), 199 orthologues and 10 paralogues. Broad expression in gall bladder (RPKM 981.2), urinary bladder (RPKM 643.2) and 14 other tissues.

Summary

This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair. [provided by RefSeq, Jul 2008]

LUM Products(1)

mRNA	Protein	Name
NM_002345.4	NP_002336.1	lumican precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables collagen binding	IDA IDA: Inferred from direct assay	10892350	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25304424	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of fibrillar collagen trimer	IDA IDA: Inferred from direct assay	10734230	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LUM Protein Structure

LRRNT

LRR_8

0
100
200
300
338 a.a.

Protein Preferred Names

Protein Names

lumican

KSPG lumican

LUM Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LUM	P51884	PRKCA	Homo sapiens	P17252	Validated Y2H	32814053
Intra	LUM	P51884	PRKCA	Homo sapiens	P17252	Y2H Pooling	32814053
Intra	LUM	P51884	PRKCA	Homo sapiens	P17252	Y2H Array	32814053
Intra	LUM	P51884	YWHAG	Homo sapiens	P61981	Y2H Pooling	32814053
Intra	LUM	P51884	YWHAG	Homo sapiens	P61981	Validated Y2H	32814053
Intra	LUM	P51884	YWHAG	Homo sapiens	P61981	Y2H Array	32814053
Intra	LUM	P51884	KAT5	Homo sapiens	Q92993	Validated Y2H	32814053
Intra	LUM	P51884	KAT5	Homo sapiens	Q92993	Y2H Pooling	32814053
Intra	LUM	P51884	KAT5	Homo sapiens	Q92993	Y2H Array	32814053
Intra	LUM	P51884	SETDB1	Homo sapiens	Q15047-2	Validated Y2H	32814053
Intra	LUM	P51884	SETDB1	Homo sapiens	Q15047-2	Y2H Array	32814053
Intra	LUM	P51884	SETDB1	Homo sapiens	Q15047-2	Y2H Pooling	32814053
Intra	LUM	P51884	MMP14	Homo sapiens	P50281	Enzymatic Study	25304424
Intra	LUM	P51884	MMP14	Homo sapiens	P50281	SPR	25304424

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LUM Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70369	Lumican/LUM Protein, Human (HEK293, His)	P51884 (Q19-N338)	≥95%

Related Diseases

Diseases

Alias

Cornea Plana

Flat Cornea

Macular Dystrophy, Corneal

Macular Corneal Dystrophy	MCD
Corneal Dystrophy, Macular Type	Groenouw Type Ii Corneal Dystrophy
Fehr Corneal Dystrophy	Macular Dystrophy, Corneal Type 1
Mcdc1	Macular Corneal Dystrophy Type Ii
Macular Corneal Dystrophy, Type Ii	Macular Corneal Dystrophy, Type I
Mcdc1, Formerly	Macular Dystrophy, Corneal, 1
Macular Corneal Dystrophy Type 1	Corneal Dystrophy Groenouw Type Ii
Corneal Dystrophy Macular Type	Macular Corneal Dystrophy Type I
Dystrophy, Macular, Corneal

Corneal Dystrophy, Posterior Amorphous

Posterior Amorphous Corneal Dystrophy	PACD
Chromosome 12q21.33 Deletion Syndrome	Posterior Amorphous Stromal Dystrophy

Degenerative Myopia

Pathological Myopia	Myopia, Degenerative
Degenerative Progressive High Myopia	Progressive High Myopia
Progressive High Myopia

Stromal Dystrophy

Myopia

Near-Sightedness	Short-Sightedness
Nearsightedness	Nearsighted
Near Vision	Close Sighted
Myopic	Short-Sighted
Near Sighted

Corneal Ectasia

Corneal Dystrophy, Congenital Stromal

Congenital Stromal Corneal Dystrophy	CSCD
Congenital Hereditary Stromal Dystrophy	Congenital Hereditary Stromal Dystrophy Of The Cornea
Congenital Stromal Dystrophy Of The Cornea	Dacs
Decorin-Associated Congenital Stromal Corneal Dystrophy	Dystrophia Corneae Parenchymatosa Congenita
Witschel Dystrophy	Dystrophy, Corneal, Stromal, Congenital

Refractive Error

Refractive Errors

Corneal Disease

Corneal Diseases

Corneal Disorders

Ehlers-Danlos Syndrome

Eds	Cutis Hyperelastica
Elastic Skin	Ehlers-Danlos Syndromes
Ed Syndrome	Ehlers Danlos Syndrome
Ehlers Danlos Disease	Eds - [Ehlers-Danlos Syndrome]

Fuchs' Endothelial Dystrophy

Fuchs Endothelial Corneal Dystrophy	Fuchs Endothelial Dystrophy
Fuchs Dystrophy	Fced
Fuchs' Corneal Dystrophy	Fuchs' Endothelial Corneal Dystrophy
Fuchs Atrophy	Fuchs Corneal Dystrophy
Endoepithelial Corneal Dystrophy	Fecd
Late Hereditary Endothelial Dystrophy	Corneal Dystrophy, Fuchs Endothelial
Dystrophy, Corneal, Fuchs Endothelial	Corneal Dystrophy, Fuchs' Endothelial, 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16747	Maralixibat chloride	Inhibitor	99.08%	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-101190	Volixibat		/	Phase 2

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-163539	Pegulicianine acetate		/	Unkown
HY-RS07891	LUM Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	LUM	VGNC	VGNC:31081
Rattus norvegicus	LUM	RGD	RGD:620984
Felis catus	LUM	VGNC	VGNC:68109
Mus musculus	LUM	MGD	MGI:109347
Canis familiaris	LUM	VGNC	VGNC:42865
Macaca mulatta	LUM	VGNC	VGNC:100076
Susscrofa domestica	LUM	NCBI
Others	LUM	NCBI

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