1. Gene
  2. OIT3 - oncoprotein induced transcript 3 Gene

OIT3 - oncoprotein induced transcript 3 Gene

Homo sapiens

Also known as LZP

Gene ID: 170392 | Gene type: protein coding

About OIT3

Cytogenetic location: 10q22.1 Genomic coordinates (GRCh38): 10:72,893,739-72,933,036 (from NCBI)

This gene has 2 transcripts (splice variants), 196 orthologues and 5 paralogues. Biased expression in liver (RPKM 29.6), small intestine (RPKM 2.8) and 3 other tissues.

Summary

This gene was identified due to its downregulation in hepatocarcinomas. The encoded protein may be involved in liver development and function. [provided by RefSeq, Sep 2016]

OIT3 Products(1)

mRNA Protein Name
NM_152635.3 NP_689848.1 oncoprotein-induced transcript 3 protein precursor
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OIT3 Protein Structure

FXa_inhibition

FXa_inhibition: Coagulation Factor Xa inhibitory site (186 - 221)

FXa_inhibition

FXa_inhibition: Coagulation Factor Xa inhibitory site (227 - 262)

Zona_pellucida

Zona_pellucida: Zona pellucida-like domain (268 - 515)

  • 0
  • 100
  • 200
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  • 400
  • 500
  • 545 a.a.
Protein Preferred Names Protein Names

oncoprotein-induced transcript 3 protein

liver-specific ZP domain-containing protein

OIT3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
OIT3 Q8WWZ8 KRTAP11-1 Homo sapiens Q8IUC1 32296183
Intra
OIT3 Q8WWZ8 KRTAP11-1 Homo sapiens Q8IUC1 32296183
Intra
OIT3 Q8WWZ8 KRTAP11-1 Homo sapiens Q8IUC1 32296183
Intra
OIT3 Q8WWZ8 LCE1F Homo sapiens Q5T754 32296183
Intra
OIT3 Q8WWZ8 LCE1F Homo sapiens Q5T754 32296183
Intra
OIT3 Q8WWZ8 LCE1F Homo sapiens Q5T754 32296183
Intra
OIT3 Q8WWZ8 LCE1C Homo sapiens Q5T751 32296183
Intra
OIT3 Q8WWZ8 LCE1C Homo sapiens Q5T751 32296183
Intra
OIT3 Q8WWZ8 LCE1C Homo sapiens Q5T751 32296183
Intra
OIT3 Q8WWZ8 MEOX2 Homo sapiens Q6FHY5 32296183
Intra
OIT3 Q8WWZ8 MEOX2 Homo sapiens Q6FHY5 32296183
Intra
OIT3 Q8WWZ8 MEOX2 Homo sapiens Q6FHY5 32296183
Intra
OIT3 Q8WWZ8 VAC14 Homo sapiens Q08AM6 32296183
Intra
OIT3 Q8WWZ8 VAC14 Homo sapiens Q08AM6 32296183
Intra
OIT3 Q8WWZ8 VAC14 Homo sapiens Q08AM6 32296183
Intra
OIT3 Q8WWZ8 CRCT1 Homo sapiens Q9UGL9 32296183
Intra
OIT3 Q8WWZ8 CRCT1 Homo sapiens Q9UGL9 32296183
Intra
OIT3 Q8WWZ8 CRCT1 Homo sapiens Q9UGL9 32296183
Intra
OIT3 Q8WWZ8 FBXO34 Homo sapiens Q9NWN3 32296183
Intra
OIT3 Q8WWZ8 FBXO34 Homo sapiens Q9NWN3 32296183
Intra
OIT3 Q8WWZ8 FBXO34 Homo sapiens Q9NWN3 32296183
Intra
OIT3 Q8WWZ8 OTX1 Homo sapiens P32242 32296183
Intra
OIT3 Q8WWZ8 OTX1 Homo sapiens P32242 32296183
Intra
OIT3 Q8WWZ8 OTX1 Homo sapiens P32242 32296183
Intra
OIT3 Q8WWZ8 HOXA1 Homo sapiens P49639 32296183
Intra
OIT3 Q8WWZ8 HOXA1 Homo sapiens P49639 32296183
Intra
OIT3 Q8WWZ8 HOXA1 Homo sapiens P49639 32296183
Intra
OIT3 Q8WWZ8 MEOX2 Homo sapiens P50222 25416956
Intra
OIT3 Q8WWZ8 MEOX2 Homo sapiens P50222 25416956
Intra
OIT3 Q8WWZ8 LCE3A Homo sapiens Q5TA76 32296183
Intra
OIT3 Q8WWZ8 LCE3A Homo sapiens Q5TA76 32296183
Intra
OIT3 Q8WWZ8 LCE3A Homo sapiens Q5TA76 32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus OIT3 MGD MGI:1201782
Macaca mulatta OIT3 VGNC VGNC:75492
Bos taurus OIT3 VGNC VGNC:58354
Rattus norvegicus OIT3 RGD RGD:735082
Felis catus OIT3 VGNC VGNC:63957