OTX1 - orthodenticle homeobox 1 Gene

Homo sapiens

Gene ID: 5013 | Gene type: protein coding

About OTX1

Cytogenetic location: 2p15 Genomic coordinates (GRCh38): 2:63,049,735-63,057,831 (from NCBI)

This gene has 6 transcripts (splice variants), 197 orthologues and 50 paralogues. Biased expression in skin (RPKM 2.2), prostate (RPKM 0.7) and 5 other tissues.

Summary

This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. A similar protein in mouse is required for proper brain and sensory organ development and can cause epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

OTX1 Products(2)

mRNA	Protein	Name
NM_001199770.2	NP_001186699.1	homeobox protein OTX1
NM_014562.4	NP_055377.1	homeobox protein OTX1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	18849347	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	18849347	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18849347	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OTX1 Protein Structure

Homeobox

TF_Otx

0
100
200
300
354 a.a.

Protein Preferred Names

Protein Names

homeobox protein OTX1

orthodenticle homolog 1

OTX1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	OTX1	P32242	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	KRTAP10-8	Homo sapiens	P60410	Validated Y2H	32296183
Intra	OTX1	P32242	KRTAP10-8	Homo sapiens	P60410	Y2H Array	25416956
Intra	OTX1	P32242	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
Intra	OTX1	P32242	KRTAP10-9	Homo sapiens	P60411	Validated Y2H	25416956
Intra	OTX1	P32242	KRTAP10-9	Homo sapiens	P60411	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	KRTAP10-9	Homo sapiens	P60411	Y2H Prey Pooling	25416956
Intra	OTX1	P32242	KRTAP10-9	Homo sapiens	P60411	Validated Y2H	32296183
Intra	OTX1	P32242	KRTAP10-9	Homo sapiens	P60411	Y2H Array	25416956
Intra	OTX1	P32242	KRTAP10-9	Homo sapiens	P60411	Y2H Array	32296183
Intra	OTX1	P32242	KRTAP10-5	Homo sapiens	P60370	Validated Y2H	32296183
Intra	OTX1	P32242	KRTAP10-5	Homo sapiens	P60370	Y2H Array	25416956
Intra	OTX1	P32242	KRTAP10-7	Homo sapiens	P60409	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	KRTAP10-7	Homo sapiens	P60409	Y2H Array	32296183
Intra	OTX1	P32242	KRTAP10-7	Homo sapiens	P60409	Validated Y2H	32296183
Intra	OTX1	P32242	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	ADAMTSL4	Homo sapiens	Q6UY14-3	Validated Y2H	32296183
Intra	OTX1	P32242	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Array	32296183
Intra	OTX1	P32242	KRTAP12-2	Homo sapiens	P59991	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	KRTAP12-2	Homo sapiens	P59991	Y2H Array	32296183
Intra	OTX1	P32242	KRTAP12-2	Homo sapiens	P59991	Validated Y2H	25416956
Intra	OTX1	P32242	KRTAP12-2	Homo sapiens	P59991	Validated Y2H	32296183
Intra	OTX1	P32242	KRTAP12-4	Homo sapiens	P60329	Validated Y2H	32296183
Intra	OTX1	P32242	KRTAP12-4	Homo sapiens	P60329	Y2H Array	32296183
Intra	OTX1	P32242	KRTAP12-4	Homo sapiens	P60329	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	RGS20	Homo sapiens	O76081-6	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	RGS20	Homo sapiens	O76081-6	Y2H Array	32296183
Intra	OTX1	P32242	KRTAP9-4	Homo sapiens	Q9BYQ2	Y2H Prey Pooling	25416956
Intra	OTX1	P32242	KRTAP9-4	Homo sapiens	Q9BYQ2	Y2H Array	25416956
Intra	OTX1	P32242	KRTAP12-1	Homo sapiens	P59990	Validated Y2H	32296183
Intra	OTX1	P32242	KRTAP12-1	Homo sapiens	P59990	Y2H Array	32296183
Intra	OTX1	P32242	KRTAP12-1	Homo sapiens	P59990	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	KRTAP10-11	Homo sapiens	P60412	Validated Y2H	25416956
Intra	OTX1	P32242	KRTAP10-11	Homo sapiens	P60412	Validated Y2H	32296183
Intra	OTX1	P32242	KRTAP10-11	Homo sapiens	P60412	Y2H Array	25416956
Intra	OTX1	P32242	KRT83	Homo sapiens	P78385	Validated Y2H	32296183
Intra	OTX1	P32242	KRTAP13-3	Homo sapiens	Q3SY46	Y2H Array	32296183
Intra	OTX1	P32242	KRTAP13-3	Homo sapiens	Q3SY46	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	KRTAP13-3	Homo sapiens	Q3SY46	Validated Y2H	32296183
Intra	OTX1	P32242	KRTAP19-7	Homo sapiens	Q3SYF9	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	KRTAP19-7	Homo sapiens	Q3SYF9	Y2H Array	32296183
Intra	OTX1	P32242	KRTAP19-7	Homo sapiens	Q3SYF9	Validated Y2H	32296183
Intra	OTX1	P32242	LCE1B	Homo sapiens	Q5T7P3	Y2H Array	31515488
Intra	OTX1	P32242	LCE1B	Homo sapiens	Q5T7P3	Y2H Prey Pooling	25416956
Intra	OTX1	P32242	LCE1B	Homo sapiens	Q5T7P3	Y2H Array	29892012
Intra	OTX1	P32242	LCE4A	Homo sapiens	Q5TA78	Y2H Array	25416956
Intra	OTX1	P32242	LCE4A	Homo sapiens	Q5TA78	Validated Y2H	25416956
Intra	OTX1	P32242	LCE4A	Homo sapiens	Q5TA78	Y2H Prey Pooling	25416956
Intra	OTX1	P32242	LCE2A	Homo sapiens	Q5TA79	Y2H Array	25416956
Intra	OTX1	P32242	LCE2D	Homo sapiens	Q5TA82	Y2H Prey Pooling	25416956
Intra	OTX1	P32242	LCE2D	Homo sapiens	Q5TA82	Validated Y2H	32296183
Intra	OTX1	P32242	LCE2D	Homo sapiens	Q5TA82	Y2H Array	25416956
Intra	OTX1	P32242	KRTAP5-6	Homo sapiens	Q6L8G9	Validated Y2H	32296183
Intra	OTX1	P32242	KRTAP5-6	Homo sapiens	Q6L8G9	Validated Y2H	25416956
Intra	OTX1	P32242	KCNK16	Homo sapiens	Q96T55	Y2H Array	25416956
Intra	OTX1	P32242	KRTAP4-11	Homo sapiens	Q9BYQ6	Validated Y2H	25416956
Intra	OTX1	P32242	KRTAP4-11	Homo sapiens	Q9BYQ6	Validated Y2H	32296183
Intra	OTX1	P32242	KRTAP9-3	Homo sapiens	Q9BYQ3	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	KRTAP9-3	Homo sapiens	Q9BYQ3	Validated Y2H	32296183
Intra	OTX1	P32242	KRTAP9-3	Homo sapiens	Q9BYQ3	Y2H Array	32296183
Intra	OTX1	P32242	KRTAP9-2	Homo sapiens	Q9BYQ4	Y2H Array	32296183
Intra	OTX1	P32242	KRTAP9-2	Homo sapiens	Q9BYQ4	Y2H Prey Pooling	25416956
Intra	OTX1	P32242	KRTAP9-2	Homo sapiens	Q9BYQ4	Validated Y2H	25416956
Intra	OTX1	P32242	KRTAP9-2	Homo sapiens	Q9BYQ4	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	KRTAP9-2	Homo sapiens	Q9BYQ4	Validated Y2H	32296183
Intra	OTX1	P32242	KRTAP9-2	Homo sapiens	Q9BYQ4	Y2H Array	25416956
Intra	OTX1	P32242	KRT37	Homo sapiens	O76014	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	KRT37	Homo sapiens	O76014	Y2H Array	32296183
Intra	OTX1	P32242	KRT85	Homo sapiens	P78386	Validated Y2H	32296183
Intra	OTX1	P32242	KRT85	Homo sapiens	P78386	Y2H Array	32296183
Intra	OTX1	P32242	KRT85	Homo sapiens	P78386	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	CCN4	Homo sapiens	O95388	Y2H Array	32296183
Intra	OTX1	P32242	CCN4	Homo sapiens	O95388	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	KRTAP11-1	Homo sapiens	Q8IUC1	Validated Y2H	32296183
Intra	OTX1	P32242	KRTAP11-1	Homo sapiens	Q8IUC1	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	KRTAP11-1	Homo sapiens	Q8IUC1	Y2H Array	32296183
Intra	OTX1	P32242	RGS20	Homo sapiens	O76081	Y2H	21516116
Intra	OTX1	P32242	RGS20	Homo sapiens	O76081	Y2H Array	31515488
Intra	OTX1	P32242	RGS20	Homo sapiens	O76081	Validated Y2H	25416956
Intra	OTX1	P32242	RGS20	Homo sapiens	O76081	Y2H Array	25416956
Intra	OTX1	P32242	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	OTX1	P32242	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	OTX1	P32242	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	OTX1	P32242	KRT35	Homo sapiens	Q92764	Y2H Array	32296183
Intra	OTX1	P32242	KRT35	Homo sapiens	Q92764	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	KRT35	Homo sapiens	Q92764	Validated Y2H	32296183
Intra	OTX1	P32242	KPRP	Homo sapiens	Q5T749	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	KPRP	Homo sapiens	Q5T749	Y2H Array	32296183
Intra	OTX1	P32242	KPRP	Homo sapiens	Q5T749	Validated Y2H	32296183
Intra	OTX1	P32242	GPRASP3	Homo sapiens	Q6PI77	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	GPRASP3	Homo sapiens	Q6PI77	Validated Y2H	32296183
Intra	OTX1	P32242	GPRASP3	Homo sapiens	Q6PI77	Y2H Array	32296183
Intra	OTX1	P32242	KRTAP1-5	Homo sapiens	Q9BYS1	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	KRTAP1-5	Homo sapiens	Q9BYS1	Validated Y2H	27107012
Intra	OTX1	P32242	KRTAP1-5	Homo sapiens	Q9BYS1	Validated Y2H	32296183
Intra	OTX1	P32242	KRTAP1-5	Homo sapiens	Q9BYS1	Y2H Array	32296183
Intra	OTX1	P32242	VWC2L	Homo sapiens	B2RUY7	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	KRTAP1-3	Homo sapiens	Q8IUG1	Validated Y2H	27107012
Intra	OTX1	P32242	KRTAP1-3	Homo sapiens	Q8IUG1	BFG-2H	27107012
Intra	OTX1	P32242	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Array	32296183
Intra	OTX1	P32242	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	KRTAP12-3	Homo sapiens	P60328	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	KRTAP12-3	Homo sapiens	P60328	Validated Y2H	32296183
Intra	OTX1	P32242	KRTAP12-3	Homo sapiens	P60328	Y2H Array	32296183
Intra	OTX1	P32242	KRTAP13-2	Homo sapiens	Q52LG2	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	KRTAP13-2	Homo sapiens	Q52LG2	Y2H Array	32296183
Intra	OTX1	P32242	KRTAP13-2	Homo sapiens	Q52LG2	Validated Y2H	32296183
Intra	OTX1	P32242	PCSK5	Homo sapiens	Q92824-2	Validated Y2H	32296183
Intra	OTX1	P32242	PCSK5	Homo sapiens	Q92824-2	Y2H Array	32296183
Intra	OTX1	P32242	PCSK5	Homo sapiens	Q92824-2	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	VWC2	Homo sapiens	Q2TAL6	Validated Y2H	32296183
Intra	OTX1	P32242	LCE1F	Homo sapiens	Q5T754	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	LCE1F	Homo sapiens	Q5T754	Y2H Array	32296183
Intra	OTX1	P32242	LCE1F	Homo sapiens	Q5T754	Validated Y2H	32296183
Intra	OTX1	P32242	KRTAP4-4	Homo sapiens	Q9BYR3	Validated Y2H	32296183
Intra	OTX1	P32242	KRTAP9-8	Homo sapiens	Q9BYQ0	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	KRTAP9-8	Homo sapiens	Q9BYQ0	Validated Y2H	32296183
Intra	OTX1	P32242	KRTAP9-8	Homo sapiens	Q9BYQ0	Y2H Array	32296183
Intra	OTX1	P32242	KRTAP1-1	Homo sapiens	Q07627	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	KRTAP1-1	Homo sapiens	Q07627	Validated Y2H	32296183
Intra	OTX1	P32242	KRTAP1-1	Homo sapiens	Q07627	Y2H Array	32296183
Intra	OTX1	P32242	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Array	32296183
Intra	OTX1	P32242	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	KRTAP6-2	Homo sapiens	Q3LI66	Validated Y2H	32296183
Intra	OTX1	P32242	KRTAP5-4	Homo sapiens	Q6L8H1	Validated Y2H	32296183
Intra	OTX1	P32242	LCE2C	Homo sapiens	Q5TA81	Validated Y2H	32296183
Intra	OTX1	P32242	LCE2C	Homo sapiens	Q5TA81	Y2H Array	32296183
Intra	OTX1	P32242	LCE2C	Homo sapiens	Q5TA81	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	KRTAP5-3	Homo sapiens	Q6L8H2	Validated Y2H	32296183
Intra	OTX1	P32242	USP54	Homo sapiens	Q70EL1-9	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	USP54	Homo sapiens	Q70EL1-9	Validated Y2H	32296183
Intra	OTX1	P32242	USP54	Homo sapiens	Q70EL1-9	Y2H Array	32296183
Intra	OTX1	P32242	KRTAP17-1	Homo sapiens	Q9BYP8	Y2H Array	32296183
Intra	OTX1	P32242	KRTAP17-1	Homo sapiens	Q9BYP8	Validated Y2H	32296183
Intra	OTX1	P32242	KRTAP17-1	Homo sapiens	Q9BYP8	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	KRTAP15-1	Homo sapiens	Q3LI76	Validated Y2H	32296183
Intra	OTX1	P32242	KRTAP4-5	Homo sapiens	Q9BYR2	Validated Y2H	32296183
Intra	OTX1	P32242	KRTAP4-5	Homo sapiens	Q9BYR2	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	KRTAP5-11	Homo sapiens	Q6L8G4	Validated Y2H	32296183
Intra	OTX1	P32242	ADAM12	Homo sapiens	O43184-4	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	ADAM12	Homo sapiens	O43184-4	Y2H Array	32296183
Intra	OTX1	P32242	NTM	Homo sapiens	Q9P121-3	Validated Y2H	32296183
Intra	OTX1	P32242	WWOX	Homo sapiens	Q9NZC7-5	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	WWOX	Homo sapiens	Q9NZC7-5	Validated Y2H	32296183
Intra	OTX1	P32242	WWOX	Homo sapiens	Q9NZC7-5	Y2H Array	32296183
Intra	OTX1	P32242	ANKRD10	Homo sapiens	Q9NXR5-2	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	ANKRD10	Homo sapiens	Q9NXR5-2	Validated Y2H	32296183
Intra	OTX1	P32242	ANKRD10	Homo sapiens	Q9NXR5-2	Y2H Array	32296183
Intra	OTX1	P32242	NECTIN3	Homo sapiens	Q9NQS3-2	Validated Y2H	32296183
Intra	OTX1	P32242	NECTIN3	Homo sapiens	Q9NQS3-2	Y2H Array	32296183
Intra	OTX1	P32242	NECTIN3	Homo sapiens	Q9NQS3-2	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	KRTAP6-1	Homo sapiens	Q3LI64	Validated Y2H	32296183
Intra	OTX1	P32242	KRTAP6-1	Homo sapiens	Q3LI64	Y2H Array	32296183
Intra	OTX1	P32242	KRTAP6-1	Homo sapiens	Q3LI64	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	FAM168B	Homo sapiens	A1KXE4-2	Y2H Array	32296183
Intra	OTX1	P32242	FAM168B	Homo sapiens	A1KXE4-2	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	KRTAP19-2	Homo sapiens	Q3LHN2	Validated Y2H	32296183
Intra	OTX1	P32242	KRTAP19-2	Homo sapiens	Q3LHN2	Y2H Array	32296183
Intra	OTX1	P32242	KRTAP19-2	Homo sapiens	Q3LHN2	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	LCE1C	Homo sapiens	Q5T751	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	LCE1C	Homo sapiens	Q5T751	Y2H Array	32296183
Intra	OTX1	P32242	LCE1C	Homo sapiens	Q5T751	Validated Y2H	32296183
Intra	OTX1	P32242	CERCAM	Homo sapiens	Q5T4B2	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	CERCAM	Homo sapiens	Q5T4B2	Validated Y2H	32296183
Intra	OTX1	P32242	CERCAM	Homo sapiens	Q5T4B2	Y2H Array	32296183
Intra	OTX1	P32242	ZBTB42	Homo sapiens	B2RXF5	Y2H Array	32296183
Intra	OTX1	P32242	ZBTB42	Homo sapiens	B2RXF5	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	SPRYD7	Homo sapiens	Q5W111-2	Validated Y2H	32296183
Intra	OTX1	P32242	SPRYD7	Homo sapiens	Q5W111-2	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	SPRYD7	Homo sapiens	Q5W111-2	Y2H Array	32296183
Intra	OTX1	P32242	CHRDL2	Homo sapiens	Q6WN34-2	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	CHRDL2	Homo sapiens	Q6WN34-2	Validated Y2H	32296183
Intra	OTX1	P32242	CHRDL2	Homo sapiens	Q6WN34-2	Y2H Array	32296183
Intra	OTX1	P32242	SLC15A2	Homo sapiens	Q16348	Validated Y2H	32296183
Intra	OTX1	P32242	SLC15A2	Homo sapiens	Q16348	Y2H Array	32296183
Intra	OTX1	P32242	SLC15A2	Homo sapiens	Q16348	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	C10orf55	Homo sapiens	Q5SWW7	Y2H Array	32296183
Intra	OTX1	P32242	C10orf55	Homo sapiens	Q5SWW7	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	C10orf55	Homo sapiens	Q5SWW7	Validated Y2H	32296183
Intra	OTX1	P32242	OXER1	Homo sapiens	Q8TDS5	Validated Y2H	32296183
Intra	OTX1	P32242	OXER1	Homo sapiens	Q8TDS5	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	OXER1	Homo sapiens	Q8TDS5	Y2H Array	32296183
Intra	OTX1	P32242	CH25H	Homo sapiens	O95992	Y2H Array	32296183
Intra	OTX1	P32242	CH25H	Homo sapiens	O95992	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	ATG9B	Homo sapiens	Q674R7-2	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	ATG9B	Homo sapiens	Q674R7-2	Validated Y2H	32296183
Intra	OTX1	P32242	ATG9B	Homo sapiens	Q674R7-2	Y2H Array	32296183
Intra	OTX1	P32242	NHLRC4	Homo sapiens	P0CG21	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	NHLRC4	Homo sapiens	P0CG21	Y2H Array	32296183
Intra	OTX1	P32242	FAM72B	Homo sapiens	Q86X60-2	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	FAM72B	Homo sapiens	Q86X60-2	Validated Y2H	32296183
Intra	OTX1	P32242	FAM72B	Homo sapiens	Q86X60-2	Y2H Array	32296183
Intra	OTX1	P32242	NDUFAF6	Homo sapiens	Q330K2-3	Validated Y2H	32296183
Intra	OTX1	P32242	NDUFAF6	Homo sapiens	Q330K2-3	Y2H Array	32296183
Intra	OTX1	P32242	NDUFAF6	Homo sapiens	Q330K2-3	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	KRTAP2-4	Homo sapiens	Q9BYR9	Y2H Array	32296183
Intra	OTX1	P32242	KRTAP2-4	Homo sapiens	Q9BYR9	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	KRTAP2-4	Homo sapiens	Q9BYR9	Validated Y2H	32296183
Intra	OTX1	P32242	KRTAP7-1	Homo sapiens	Q8IUC3	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	KRTAP7-1	Homo sapiens	Q8IUC3	Y2H Array	32296183
Intra	OTX1	P32242	KRTAP7-1	Homo sapiens	Q8IUC3	Validated Y2H	32296183
Intra	OTX1	P32242	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Array	32296183
Intra	OTX1	P32242	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Array	32296183
Intra	OTX1	P32242	UBAP2	Homo sapiens	Q5T6F2	Validated Y2H	32296183
Intra	OTX1	P32242	UBAP2	Homo sapiens	Q5T6F2	Y2H Array	32296183
Intra	OTX1	P32242	COMP	Homo sapiens	P49747	Validated Y2H	32296183
Intra	OTX1	P32242	COMP	Homo sapiens	P49747	Y2H Array	31515488
Intra	OTX1	P32242	COMP	Homo sapiens	P49747	Y2H Prey Pooling	25416956
Intra	OTX1	P32242	MIIP	Homo sapiens	Q5JXC2	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	MIIP	Homo sapiens	Q5JXC2	Validated Y2H	32296183
Intra	OTX1	P32242	MIIP	Homo sapiens	Q5JXC2	Y2H Array	32296183
Intra	OTX1	P32242	ETFDH	Homo sapiens	Q16134	Validated Y2H	32296183
Intra	OTX1	P32242	ETFDH	Homo sapiens	Q16134	Y2H Array	32296183
Intra	OTX1	P32242	ETFDH	Homo sapiens	Q16134	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	KRTAP4-1	Homo sapiens	Q9BYQ7	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	KRTAP4-1	Homo sapiens	Q9BYQ7	Y2H Array	32296183
Intra	OTX1	P32242	SPRY4	Homo sapiens	Q9C004	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	SPRY4	Homo sapiens	Q9C004	Validated Y2H	32296183
Intra	OTX1	P32242	SPRY4	Homo sapiens	Q9C004	Y2H Array	32296183
Intra	OTX1	P32242	SMARCC1	Homo sapiens	Q92922	Validated Y2H	25416956
Intra	OTX1	P32242	TARDBP	Homo sapiens	Q13148	Validated Y2H	32814053
Intra	OTX1	P32242	TARDBP	Homo sapiens	Q13148	Y2H Array	32814053
Intra	OTX1	P32242	TARDBP	Homo sapiens	Q13148	Y2H Pooling	32814053
Intra	OTX1	P32242	ZNF330	Homo sapiens	Q9Y3S2	Validated Y2H	32296183
Intra	OTX1	P32242	SPRY1	Homo sapiens	O43609	Y2H Array	25416956
Intra	OTX1	P32242	SPRY1	Homo sapiens	O43609	Validated Y2H	25416956
Intra	OTX1	P32242	SPRY1	Homo sapiens	O43609	Y2H Array	31515488
Intra	OTX1	P32242	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	OTX1	P32242	RGS17	Homo sapiens	Q9UGC6	Y2H Prey Pooling	25416956
Intra	OTX1	P32242	RGS17	Homo sapiens	Q9UGC6	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	RGS17	Homo sapiens	Q9UGC6	Validated Y2H	32296183
Intra	OTX1	P32242	RGS17	Homo sapiens	Q9UGC6	Y2H Array	32296183
Intra	OTX1	P32242	PLSCR2	Homo sapiens	Q9NRY7	Y2H Array	32296183
Intra	OTX1	P32242	PLSCR2	Homo sapiens	Q9NRY7	Validated Y2H	32296183
Intra	OTX1	P32242	PLSCR2	Homo sapiens	Q9NRY7	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	KRTAP26-1	Homo sapiens	Q6PEX3	Validated Y2H	25416956
Intra	OTX1	P32242	KRTAP26-1	Homo sapiens	Q6PEX3	Y2H Array	25416956
Intra	OTX1	P32242	KRTAP3-3	Homo sapiens	Q9BYR6	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	KRTAP3-3	Homo sapiens	Q9BYR6	Y2H Array	32296183
Intra	OTX1	P32242	KRTAP3-3	Homo sapiens	Q9BYR6	Validated Y2H	32296183
Intra	OTX1	P32242	KRTAP3-3	Homo sapiens	Q9BYR6	Y2H Prey Pooling	25416956
Intra	OTX1	P32242	LGALS13	Homo sapiens	Q9UHV8	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	LGALS13	Homo sapiens	Q9UHV8	Validated Y2H	32296183
Intra	OTX1	P32242	LGALS13	Homo sapiens	Q9UHV8	Y2H Array	32296183
Intra	OTX1	P32242	KRTAP5-9	Homo sapiens	P26371	Validated Y2H	25416956
Intra	OTX1	P32242	KRTAP5-9	Homo sapiens	P26371	Y2H Array	32296183
Intra	OTX1	P32242	KRTAP5-9	Homo sapiens	P26371	Y2H Prey Pooling	25416956
Intra	OTX1	P32242	KRTAP5-9	Homo sapiens	P26371	Y2H Array	25416956
Intra	OTX1	P32242	KRTAP5-9	Homo sapiens	P26371	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	TRIM42	Homo sapiens	Q8IWZ5	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	TRIM42	Homo sapiens	Q8IWZ5	Validated Y2H	32296183
Intra	OTX1	P32242	TRIM42	Homo sapiens	Q8IWZ5	Y2H Array	32296183
Intra	OTX1	P32242	RTN4R	Homo sapiens	Q9BZR6	Validated Y2H	32296183
Intra	OTX1	P32242	RTN4R	Homo sapiens	Q9BZR6	Y2H Array	32296183
Intra	OTX1	P32242	RTN4R	Homo sapiens	Q9BZR6	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	EFEMP1	Homo sapiens	Q12805	Validated Y2H	32296183
Intra	OTX1	P32242	NDUFV2	Homo sapiens	P19404	Validated Y2H	32814053
Intra	OTX1	P32242	NDUFV2	Homo sapiens	P19404	Y2H Pooling	32814053
Intra	OTX1	P32242	NDUFV2	Homo sapiens	P19404	Y2H Array	32814053
Intra	OTX1	P32242	CFAP68	Homo sapiens	Q9H5F2	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	CFAP68	Homo sapiens	Q9H5F2	Validated Y2H	32296183
Intra	OTX1	P32242	CFAP68	Homo sapiens	Q9H5F2	Y2H Array	32296183
Intra	OTX1	P32242	MDFI	Homo sapiens	Q99750	Validated Y2H	32296183
Intra	OTX1	P32242	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	MDFI	Homo sapiens	Q99750	Y2H Array	32296183
Intra	OTX1	P32242	MDFI	Homo sapiens	Q99750	Y2H Array	30886144
Intra	OTX1	P32242	MDFI	Homo sapiens	Q99750	BFG-2H	27107012
Intra	OTX1	P32242	MDFI	Homo sapiens	Q99750	Y2H Pooling	19447967
Intra	OTX1	P32242	KLHL26	Homo sapiens	Q53HC5	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	KLHL26	Homo sapiens	Q53HC5	Validated Y2H	32296183
Intra	OTX1	P32242	KLHL26	Homo sapiens	Q53HC5	Y2H Array	32296183
Intra	OTX1	P32242	PLA2G10	Homo sapiens	O15496	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	PLA2G10	Homo sapiens	O15496	Y2H Array	32296183
Intra	OTX1	P32242	KRT81	Homo sapiens	Q14533	Validated Y2H	25416956
Intra	OTX1	P32242	KRT81	Homo sapiens	Q14533	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	KRT81	Homo sapiens	Q14533	Validated Y2H	32296183
Intra	OTX1	P32242	KRTAP4-12	Homo sapiens	Q9BQ66	Y2H Array	32296183
Intra	OTX1	P32242	KRTAP4-12	Homo sapiens	Q9BQ66	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	KRTAP4-12	Homo sapiens	Q9BQ66	Validated Y2H	25416956
Intra	OTX1	P32242	KRTAP4-12	Homo sapiens	Q9BQ66	Y2H Pooling	16189514
Intra	OTX1	P32242	KRTAP4-12	Homo sapiens	Q9BQ66	Validated Y2H	32296183
Intra	OTX1	P32242	KRTAP4-12	Homo sapiens	Q9BQ66	Y2H Array	25416956
Intra	OTX1	P32242	RBPMS	Homo sapiens	Q93062	Y2H Prey Pooling	25416956
Intra	OTX1	P32242	RBPMS	Homo sapiens	Q93062	Y2H Array	25416956
Intra	OTX1	P32242	RBPMS	Homo sapiens	Q93062	Y2H Pooling	16189514
Intra	OTX1	P32242	PRR13	Homo sapiens	Q9NZ81	Validated Y2H	32296183
Intra	OTX1	P32242	PRR13	Homo sapiens	Q9NZ81	Y2H Array	32296183
Intra	OTX1	P32242	PRR13	Homo sapiens	Q9NZ81	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	CHIC2	Homo sapiens	Q9UKJ5	Y2H Pooling	16189514
Intra	OTX1	P32242	CHIC2	Homo sapiens	Q9UKJ5	Validated Y2H	32296183
Intra	OTX1	P32242	CHIC2	Homo sapiens	Q9UKJ5	Y2H Array	32296183
Intra	OTX1	P32242	CHIC2	Homo sapiens	Q9UKJ5	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	TRIP6	Homo sapiens	Q15654	Validated Y2H	32296183
Intra	OTX1	P32242	TRIP6	Homo sapiens	Q15654	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	TRIP6	Homo sapiens	Q15654	Y2H Array	32296183
Intra	OTX1	P32242	SPRY2	Homo sapiens	O43597	Y2H Array	25416956
Intra	OTX1	P32242	SPMIP9	Homo sapiens	Q96LM6	Validated Y2H	32296183
Intra	OTX1	P32242	SPMIP9	Homo sapiens	Q96LM6	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	SPMIP9	Homo sapiens	Q96LM6	Y2H Array	32296183
Intra	OTX1	P32242	COL8A1	Homo sapiens	P27658	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	COL8A1	Homo sapiens	P27658	Y2H Array	32296183
Intra	OTX1	P32242	GRN	Homo sapiens	P28799	Y2H Array	31515488
Intra	OTX1	P32242	M1AP	Homo sapiens	Q8TC57	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	M1AP	Homo sapiens	Q8TC57	Validated Y2H	32296183
Intra	OTX1	P32242	M1AP	Homo sapiens	Q8TC57	Y2H Array	32296183
Intra	OTX1	P32242	INTS11	Homo sapiens	Q5TA45	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	INTS11	Homo sapiens	Q5TA45	Validated Y2H	32296183
Intra	OTX1	P32242	INTS11	Homo sapiens	Q5TA45	Y2H Array	32296183
Intra	OTX1	P32242	FHL5	Homo sapiens	Q5TD97	Validated Y2H	32296183
Intra	OTX1	P32242	FHL5	Homo sapiens	Q5TD97	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	FHL5	Homo sapiens	Q5TD97	Y2H Array	32296183
Intra	OTX1	P32242	KRTAP3-2	Homo sapiens	Q9BYR7	Y2H Array	31515488
Intra	OTX1	P32242	KRTAP3-2	Homo sapiens	Q9BYR7	Validated Y2H	25416956
Intra	OTX1	P32242	KRTAP3-2	Homo sapiens	Q9BYR7	Validated Y2H	32296183
Intra	OTX1	P32242	KRTAP3-2	Homo sapiens	Q9BYR7	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	KRTAP3-2	Homo sapiens	Q9BYR7	Y2H Array	32296183
Intra	OTX1	P32242	KRTAP3-2	Homo sapiens	Q9BYR7	Y2H Prey Pooling	25416956
Intra	OTX1	P32242	ARHGEF17	Homo sapiens	Q96PE2	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	ARHGEF17	Homo sapiens	Q96PE2	Validated Y2H	32296183
Intra	OTX1	P32242	TSPAN4	Homo sapiens	O14817	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	TSPAN4	Homo sapiens	O14817	Y2H Array	32296183
Intra	OTX1	P32242	RGS19	Homo sapiens	P49795	Validated Y2H	32296183
Intra	OTX1	P32242	RGS19	Homo sapiens	P49795	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	RGS19	Homo sapiens	P49795	Y2H Array	32296183
Intra	OTX1	P32242	LASP1	Homo sapiens	Q14847-2	Validated Y2H	32296183
Intra	OTX1	P32242	LASP1	Homo sapiens	Q14847-2	Y2H Array	32296183
Intra	OTX1	P32242	LASP1	Homo sapiens	Q14847-2	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	DNMT3A	Homo sapiens	Q9Y6K1	Validated Y2H	32296183
Intra	OTX1	P32242	POU2AF1	Homo sapiens	Q16633	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	POU2AF1	Homo sapiens	Q16633	Validated Y2H	32296183
Intra	OTX1	P32242	POU2AF1	Homo sapiens	Q16633	Y2H Array	32296183
Intra	OTX1	P32242	FBLN2	Homo sapiens	P98095	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	FBLN2	Homo sapiens	P98095	Validated Y2H	32296183
Intra	OTX1	P32242	FBLN2	Homo sapiens	P98095	Y2H Array	32296183
Intra	OTX1	P32242	KRT31	Homo sapiens	Q15323	Validated Y2H	32296183
Intra	OTX1	P32242	KRT31	Homo sapiens	Q15323	Y2H Array	32296183
Intra	OTX1	P32242	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	ARID5A	Homo sapiens	Q03989	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	ARID5A	Homo sapiens	Q03989	Y2H Array	32296183
Intra	OTX1	P32242	ARID5A	Homo sapiens	Q03989	Validated Y2H	32296183
Intra	OTX1	P32242	PLEKHG4	Homo sapiens	Q58EX7	Y2H Prey Pooling	32296183
Intra	OTX1	P32242	PLEKHG4	Homo sapiens	Q58EX7	Y2H Array	32296183
Intra	OTX1	P32242	PLEKHG4	Homo sapiens	Q58EX7	Validated Y2H	32296183
Intra	OTX1	P32242	TNS2	Homo sapiens	Q63HR2	Validated Y2H	32296183
Intra	OTX1	P32242	KRTAP3-1	Homo sapiens	Q9BYR8	Validated Y2H	32296183
Intra	OTX1	P32242	KRTAP3-1	Homo sapiens	Q9BYR8	Y2H Array	32296183
Intra	OTX1	P32242	KRTAP3-1	Homo sapiens	Q9BYR8	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

OTX1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83384	OTX1 Antibody (YA3129)	WB	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Agnathia-Otocephaly Complex

Otocephaly	Holoprosencephaly-Agnathia
Dysgnathia Complex Agnathia-Holoprosencephaly	AGOTC
Agnathia-Holoprosencephaly-Situs Inversus Syndrome	Dysgnathia Complex
Agnathia-Holoprosencephaly	Cervical Auricle

Epilepsy

Epilepsy Syndrome	Epileptic Syndrome
Epilepsies	Symptomatic Epilepsies
Post Traumatic Epilepsy	Traumatic Epilepsy
Traumatic Epileptic	Epilepsy Due To Hippocampal Sclerosis
Epilepsy With Ammon'S Horn Sclerosis	Epilepsy Due To Cortical Dysplasia
Epilepsy Due To Neuronal Migration Disorders

Dyslexia

Achromatopsia 7

ACHM7

Achromatopsia, Type 7

Medulloblastoma

MDB	Cpnet
Localized Primitive Neuroectodermal Tumor	Classic Medulloblastoma
Medulloblastoma Predisposition Syndrome	Medulloblastoma, Somatic
Brain Medulloblastoma	Cns Pnet
Infratentorial Primitive Neuroectodermal Tumor	Neuroectodermal Tumors, Primitive
Medulloblastomas	Desmoplastic Medulloblastoma
Medulloblastoma, With Extensive Nodularity	Medulloblastoma Of Unspecified Site
Medullomyoblastoma Of Unspecified Site

Cone-Rod Dystrophy 2

Cone-Rod Dystrophy	CORD2
Cone-Rod Retinal Dystrophy	Rcrd2
Cone-Rod Retinal Dystrophy 2	Crd2
Cord	Crd
Retinal Cone-Rod Dystrophy	Cone-Rod Retinal Dystrophy-2
Retinal Cone-Rod Dystrophy 2	Tapetoretinal Degeneration
Cone-Rod Degeneration	Cone Rod Dystrophy
Dystrophy, Cone-Rod	Dystrophy, Cone-Rod, Type 2
Retinitis Pigmentosa	Retinitis Pigmentosa 2
Progressive Cone-Rod Dystrophy

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09879	OTX1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	OTX1	VGNC	VGNC:44193
Rattus norvegicus	OTX1	RGD	RGD:3237
Mus musculus	OTX1	MGD	MGI:97450
Bos taurus	OTX1	VGNC	VGNC:32502
Macaca mulatta	OTX1	VGNC	VGNC:75726

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