Lcn2 - lipocalin 2 Gene

Rattus norvegicus

Also known as Sip24

Gene ID: 170496 | Gene type: protein coding

About Lcn2

Summary

Enables enterobactin binding activity; identical protein binding activity; and protease binding activity. Involved in several processes, including cellular response to cytokine stimulus; memory; and regulation of neuron apoptotic process. Located in cytosol and extracellular space. Used to study intrahepatic cholangiocarcinoma and retinal degeneration. Biomarker of several diseases, including acute kidney failure; congenital diaphragmatic hernia; obesity; pulmonary hypertension; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in urinary tract Infection. Orthologous to human LCN2 (lipocalin 2). [provided by Alliance of Genome Resources, Apr 2022]

Lcn2 Products(1)

mRNA	Protein	Name
NM_130741.1	NP_570097.1	neutrophil gelatinase-associated lipocalin precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables enterobactin binding	IPI IPI: Inferred from physical interaction	26004810	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	17148685	RGD
enables protease binding	IPI IPI: Inferred from physical interaction	17148685	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in acute-phase response	IEP IEP: Inferred from expression pattern	22249220	RGD
involved in cellular response to X-ray	IEP IEP: Inferred from expression pattern	23331620	RGD
involved in cellular response to amyloid-beta	IEP IEP: Inferred from expression pattern	24853299	RGD
involved in cellular response to hydrogen peroxide	IDA IDA: Inferred from direct assay	19129400	RGD
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	24916903	RGD
involved in cellular response to increased oxygen levels	IEP IEP: Inferred from expression pattern	24916903	RGD
involved in cellular response to interleukin-1	IEP IEP: Inferred from expression pattern	19329498	RGD
involved in cellular response to interleukin-6	IEP IEP: Inferred from expression pattern	22249220	RGD
involved in cellular response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	19329498	RGD
involved in cellular response to nerve growth factor stimulus	IEP IEP: Inferred from expression pattern	25412834	RGD
involved in cellular response to nutrient levels	IEP IEP: Inferred from expression pattern	17356516	RGD
involved in cellular response to tumor necrosis factor	IEP IEP: Inferred from expression pattern	19329498	RGD
involved in long-term memory	IMP IMP: Inferred from mutant phenotype	32174475	RGD
involved in negative regulation of hippocampal neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	32174475	RGD
involved in positive regulation of apoptotic process	IGI IGI: Inferred from genetic interaction	26013918	RGD
involved in positive regulation of cell projection organization	IDA IDA: Inferred from direct assay	19129400	RGD
involved in positive regulation of endothelial cell migration	IDA IDA: Inferred from direct assay	25557118	RGD
involved in positive regulation of endothelial tube morphogenesis	IDA IDA: Inferred from direct assay	25557118	RGD
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	19860839	RGD
involved in positive regulation of hippocampal neuron apoptotic process	IDA IDA: Inferred from direct assay	26004810	RGD
involved in positive regulation of iron ion import across plasma membrane	IDA IDA: Inferred from direct assay	25557118	RGD
involved in positive regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	30574656	RGD
involved in positive regulation of reactive oxygen species biosynthetic process	IDA IDA: Inferred from direct assay	25557118	RGD
involved in positive regulation of reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	30574656	RGD
involved in response to bacterium	IEP IEP: Inferred from expression pattern	19303090	RGD
involved in response to blue light	IEP IEP: Inferred from expression pattern	30574656	RGD
involved in response to fructose	IEP IEP: Inferred from expression pattern	24587658	RGD
involved in response to herbicide	IDA IDA: Inferred from direct assay	19129400	RGD
involved in response to iron(II) ion	IEP IEP: Inferred from expression pattern	23416150	RGD
involved in response to kainic acid	IEP IEP: Inferred from expression pattern	26004810	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	26004810	RGD
involved in response to mycotoxin	IEP IEP: Inferred from expression pattern	18308701	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	19221211	RGD
involved in response to oxidative stress	IEP IEP: Inferred from expression pattern	17553663	RGD
involved in response to toxic substance	IEP IEP: Inferred from expression pattern	22366155	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	20043115	RGD
involved in response to xenobiotic stimulus	IMP IMP: Inferred from mutant phenotype	19860839	RGD
involved in short-term memory	IMP IMP: Inferred from mutant phenotype	32174475	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	20057160	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

neutrophil gelatinase-associated lipocalin

NGAL	alpha-2-microglobulin-related protein
alpha-2U globulin-related protein	lipocalin 2 (oncogene 24p3)
lipocalin 24p3	p25
siderocalin LCN2

Recombinant Lcn2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74774	Lipocalin-2/NGAL Protein, Rat (sf9, His)	P30152 (Q21-N198)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-Q45780	ZINC00640089		99.82%	Unkown
HY-148364	ZINC00784494		99.32%	Unkown
HY-RS07557	LCN2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-132195	RORγt inverse agonist 14	Inhibitor	/	Unkown
HY-158049	Anticancer agent 199	Inducer	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lcn2	NCBI	NCBI:3934
Macaca fascicularis	Lcn2	NCBI	NCBI:102137149
Mus musculus	Lcn2	NCBI	NCBI:16819

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