Cygb - cytoglobin Gene

Rattus norvegicus

Also known as Glnf; Stap; Staap

Gene ID: 170520 | Gene type: protein coding

About Cygb

Summary

Enables catalase activity; fatty acid peroxidase activity; and heme binding activity. Involved in several processes, including negative regulation of collagen biosynthetic process; negative regulation of fibroblast migration; and negative regulation of hepatic stellate cell activation. Located in cytoplasm. Used to study liver cirrhosis and renal fibrosis. Biomarker of kidney disease and liver cirrhosis. Orthologous to human CYGB (cytoglobin). [provided by Alliance of Genome Resources, Apr 2022]

Cygb Products(1)

mRNA	Protein	Name
NM_130744.2	NP_570100.1	cytoglobin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables catalase activity	IDA IDA: Inferred from direct assay	11320098	RGD
enables fatty acid peroxidase activity	IDA IDA: Inferred from direct assay	11320098	RGD
enables heme binding	IDA IDA: Inferred from direct assay	11320098	RGD
enables nitric oxide dioxygenase activity, heme protein as donor	IDA IDA: Inferred from direct assay	28393874	RGD
enables peroxidase activity	IDA IDA: Inferred from direct assay	11320098	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in fatty acid oxidation	IDA IDA: Inferred from direct assay	11320098	RGD
involved in negative regulation of collagen biosynthetic process	IDA IDA: Inferred from direct assay	20719976	RGD
involved in negative regulation of fibroblast migration	IDA IDA: Inferred from direct assay	14647402	RGD
involved in negative regulation of hepatic stellate cell activation	IDA IDA: Inferred from direct assay	16581302	RGD
involved in nitric oxide catabolic process	IMP IMP: Inferred from mutant phenotype	28393874	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	14660570	RGD
involved in response to oxidative stress	IDA IDA: Inferred from direct assay	11320098	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	14647402	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cytoglobin

HGb	globin f
histoglobin	stellate cell activation-associated protein

Recombinant Cygb Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72162	CYGB Protein, Rat (His-Myc)	Q921A4 (M1-P190)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03432	CYGB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cygb	NCBI	NCBI:114757

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