CYGB - cytoglobin Gene

Homo sapiens

Also known as HGB; STAP

Gene ID: 114757 | Gene type: protein coding

About CYGB

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:76,527,356-76,551,193 (from NCBI)

This gene has 5 transcripts (splice variants), 287 orthologues and 11 paralogues. Ubiquitous expression in fat (RPKM 16.5), urinary bladder (RPKM 7.0) and 23 other tissues.

Summary

This gene encodes a globin protein found in vertebrate cells. The encoded protein is described as a hexacoordinate hemoglobin which binds ligand differently from the pentacoordinate hemoglobins involved in oxygen transport, and may be involved in protection during oxidative stress. This gene is located on chromosome 17 in the same region as a retinal gene which is mutated in progressive rod-cone degeneration, but in the opposite orientation. [provided by RefSeq, Jan 2012]

CYGB Products(1)

mRNA	Protein	Name
NM_134268.5	NP_599030.1	cytoglobin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables carbon monoxide binding	IDA IDA: Inferred from direct assay	11893755	GOA
enables nitric oxide dioxygenase activity, heme protein as donor	IDA IDA: Inferred from direct assay	20511233	GOA
enables nitrite reductase activity	IDA IDA: Inferred from direct assay	29128400	GOA
enables oxygen binding	IDA IDA: Inferred from direct assay	11893755	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables superoxide dismutase activity	IDA IDA: Inferred from direct assay	34930834	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in nitric oxide catabolic process	IDA IDA: Inferred from direct assay	28671819	GOA
involved in removal of superoxide radicals	IDA IDA: Inferred from direct assay	34930834	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	34930834	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	14660570	GOA
located in nucleus	IDA IDA: Inferred from direct assay	14660570	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CYGB Protein Structure

Globin

0
100
190 a.a.

Protein Preferred Names

Protein Names

cytoglobin

histoglobin

CYGB Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CYGB	Q8WWM9	LRATD1	Homo sapiens	Q96KN4	Validated Y2H	32296183
Intra	CYGB	Q8WWM9	LRATD1	Homo sapiens	Q96KN4	Y2H Array	32296183
Intra	CYGB	Q8WWM9	LRATD1	Homo sapiens	Q96KN4	Y2H Prey Pooling	32296183
Intra	CYGB	Q8WWM9	PRR5-ARHGAP8	Homo sapiens	B1AHC3	Y2H Array	32296183
Intra	CYGB	Q8WWM9	PRR5-ARHGAP8	Homo sapiens	B1AHC3	Y2H Prey Pooling	32296183
Intra	CYGB	Q8WWM9	MZT1	Homo sapiens	Q08AG7	Y2H Prey Pooling	32296183
Intra	CYGB	Q8WWM9	MZT1	Homo sapiens	Q08AG7	Y2H Array	32296183
Intra	CYGB	Q8WWM9	DDI1	Homo sapiens	Q8WTU0	Y2H Prey Pooling	25416956
Intra	CYGB	Q8WWM9	DDI1	Homo sapiens	Q8WTU0	Validated Y2H	25416956
Intra	CYGB	Q8WWM9	DDI1	Homo sapiens	Q8WTU0	Y2H Prey Pooling	32296183
Intra	CYGB	Q8WWM9	DDI1	Homo sapiens	Q8WTU0	Y2H Array	25416956
Intra	CYGB	Q8WWM9	DDI1	Homo sapiens	Q8WTU0	Y2H Array	32296183
Intra	CYGB	Q8WWM9	AKR7A2	Homo sapiens	O43488	Anti Tag CoIP	28536627
Intra	CYGB	Q8WWM9	AKR7A2	Homo sapiens	O43488	Y2H	28536627
Intra	CYGB	Q8WWM9	ARHGAP8	Homo sapiens	P85298-4	Y2H Array	32296183
Intra	CYGB	Q8WWM9	ARHGAP8	Homo sapiens	P85298-4	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CYGB Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70089	Cytoglobin/Histoglobin Protein, Human (His)	Q8WWM9 (M1-P190)	≥95%

Related Diseases

Diseases

Alias

Retinitis Pigmentosa 36

RP36	Retinitis Pigmentosa-36
Retinitis Pigmentosa, Type 36

Cone-Rod Dystrophy 2

Cone-Rod Dystrophy	CORD2
Cone-Rod Retinal Dystrophy	Rcrd2
Cone-Rod Retinal Dystrophy 2	Crd2
Cord	Crd
Retinal Cone-Rod Dystrophy	Cone-Rod Retinal Dystrophy-2
Retinal Cone-Rod Dystrophy 2	Tapetoretinal Degeneration
Cone-Rod Degeneration	Cone Rod Dystrophy
Dystrophy, Cone-Rod	Dystrophy, Cone-Rod, Type 2
Retinitis Pigmentosa	Retinitis Pigmentosa 2
Progressive Cone-Rod Dystrophy

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Fundus Dystrophy

Retinal Dystrophy	Retinal Dystrophies
Dystrophy, Retinal

Esophageal Diverticulosis

Diverticulosis, Esophageal

Atrophic Vulva

Atrophy Of Vulva

Epidural Abscess

Abscess Epidural

Xanthogranulomatous Pyelonephritis

Pyelonephritis, Xanthogranulomatous

Deficiency Anemia

Anemia	Deficiency Anemias
Anaemia

Bladder Tuberculosis

Tuberculous Cystitis

Tuberculosis Of Bladder

Epiglottis Cancer

Epiglottic Cancer

Malignant Tumor Of Epiglottis

Acquired Polycythemia

Secondary Polycythemia	Polycythemia, Secondary
Secondary Erythrocytosis	Polycythemia Secondary

Femoral Neuropathy

Femoral Nerve Dysfunction

Femoral Nerve Lesions

Thalassemia Minor

Active Peptic Ulcer Disease

Gi Bleeding	Active Peptic Ulcer
Gastrointestinal Hemorrhage

Iron Deficiency Anemia

Iron-Deficiency Anemia	Fe Deficiency Anaemia
Ida - [Iron Deficiency Anemia]	Fe - [Iron] Deficiency Anemia Nos

Acute Chest Syndrome

Acute Chest Syndrome In Sickle Cell Disease

Splenic Infarction

Splenic Infarct	Splenic Infarcts
Infarct Of The Spleen

Compartment Syndrome

Compartment Syndromes

Compartmental Syndrome

Idiopathic Peripheral Autonomic Neuropathy

Leech Infestation

Hirudiniasis

Leeches

Hemoglobinopathy

Hemoglobinopathies

Inflammatory Liposarcoma

Sickle Cell Anemia

Hemoglobin Sc Disease	Anemia, Sickle Cell
Hbsc Disease	Sickle Cell-Hemoglobin C Disease Syndrome
Hb Ss Disease	Sickle Cell Trait
Drepanocytosis	Haemoglobin Sc Disease
Hb Sc Disease	Hb-S/Hb-C Disease
Hb-Ss Disease Without Crisis	Hemoglobin S Disease Without Crisis
Sickle Cell Anaemia	Sickle-Cell/Hb-C Disease Without Crisis
Sickle Cell - Hemoglobin C Disease	Hbs Disease
Hemoglobin S Disease	Sickling Disorder Due To Hemoglobin S
SKCA	Sickle Cell Disease
Sickle Cell-Hemoglobin C Disease	Sickle-Cell Disease Carrier
Sickle-Cell Heterozygous Disorder	Haemoglobin A-S Genotype
Hb-S - [Sickle Cell Haemoglobin] Carrier	Sickle Cell Haemoglobin Trait
As - [Sickle Cell Trait]	Hbas - [Sickle Cell Haemoglobin Trait]
Sickle-Cell Trait Haemoglobin Disease	Haemoglobin Sickle Cell Trait Disorder
Heterozygous Sickle Cell Trait	Hbas - [Heterozygous Haemoglobin S]

Breast Rhabdomyosarcoma

Rhabdomyosarcoma Of The Breast

Anemia, Nonspherocytic Hemolytic, Due To G6pd Deficiency

Favism	Favism, Susceptibility To
Hemolytic Anemia, G6pd Deficient	Class I Glucose-6-Phosphate Dehydrogenase Deficiency
Class I G6pd Deficiency	Severe Hemolytic Anemia Due To G6pd Deficiency
Anemia, Non-Spherocytic Hemolytic, Due To G6pd Deficiency	NSHA
G6pd Deficient Hemolytic Anemia

Geotrichosis

Blood Platelet Disease

Platelet Disorder	Blood Platelet Disorders
Thrombocytopathy	Platelet Dysfunction
Platelet Disorders	Qualitative Platelet Deficiency

Lipoma Of Colon

Colonic Lipoma

Colon Lipoma

Large Intestine Lipoma

Lipoma Of Large Intestine

Colorectal Lipoma

Pancytopenia

Bilirubin Metabolic Disorder

Hyperbilirubinemia	Hereditary Hyperbilirubinemia
Hyperbilirubinemia, Hereditary	Hyperbilirubinaemia

Lipoprotein Quantitative Trait Locus

Coronary Artery Disease	Coronary Artery Anomaly
Coronary Artery Disease, Susceptibility To	Myocardial Ischemia
Congenital Anomaly Of Coronary Artery	Coronary Arteriosclerosis
Coronary Disease	Coronary Heart Disease
Coronary Artery Disorder	LPAQTL
Lpa Deficiency, Congenital	Coronary Artery Abnormality
Coronary Artery Anomaly, Congenital	Chd
Coronary Syndrome	Congenital Malformations Of Coronary Vessels
Malformation Of Coronary Vessels	Congenital Coronary Artery Anomaly
Congenital Coronary Artery Deformity	Congenital Coronary Artery Disorder
Abnormal Coronary Artery	Congenital Coronary Artery Malposition
Congenital Coronary Disease	Congenital Anomaly Of Coronary Arteries

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03432	CYGB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CYGB	VGNC	VGNC:71421
Mus musculus	CYGB	MGD	MGI:2149481
Felis catus	CYGB	VGNC	VGNC:61317
Canis familiaris	CYGB	VGNC	VGNC:49090
Rattus norvegicus	CYGB	RGD	RGD:69415
Bos taurus	CYGB	VGNC	VGNC:50268
Others	CYGB	NCBI