Prkcd - protein kinase C, delta Gene

Rattus norvegicus

Also known as Pkcd

Gene ID: 170538 | Gene type: protein coding

About Prkcd

Primary_assembly 16: 5,769,215-5,799,352 reverse strand.mRatBN7.2:CM026989.1

This gene has 3 transcripts (splice variants), 289 orthologues, 5 paralogues and is associated with 27 phenotypes. Biased expression in Lung (RPKM 21.4), Spleen (RPKM 28.8) and 9 other tissues.

Summary

Enables TIR domain binding activity; calcium-independent protein kinase C activity; and protein kinase binding activity. Involved in several processes, including D-aspartate import across plasma membrane; positive regulation of MAP kinase activity; and positive regulation of glucose import. Located in several cellular components, including cytosol; mitochondrion; and nucleus. Is active in postsynaptic cytosol. Used to study brain ischemia and hypertension. Biomarker of hyperinsulinism; hypertension; muscular disease; obesity; and restrictive cardiomyopathy. Human ortholog(s) of this gene implicated in autoimmune lymphoproliferative syndrome type 3 and fatty liver disease. Orthologous to human PRKCD (protein kinase C delta). [provided by Alliance of Genome Resources, Apr 2022]

Prkcd Products(1)

mRNA	Protein	Name
NM_133307.2	NP_579841.2	protein kinase C delta type

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables TIR domain binding	IPI IPI: Inferred from physical interaction	17161867	RGD
enables diacylglycerol-dependent serine/threonine kinase activity	EXP EXP: Inferred from Experiment	12198130	RGD
enables diacylglycerol-dependent, calcium-independent serine/threonine kinase activity	IDA IDA: Inferred from direct assay	1915352	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9514928	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	15337529	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in D-aspartate import across plasma membrane	IMP IMP: Inferred from mutant phenotype	17364745	RGD
involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	21696630	RGD
involved in cellular response to glucose starvation	IEP IEP: Inferred from expression pattern	17728702	RGD
involved in cellular response to insulin stimulus	IEP IEP: Inferred from expression pattern	17046201	RGD
involved in cellular response to oxidative stress	IDA IDA: Inferred from direct assay	21696630	RGD
involved in collagen metabolic process	IMP IMP: Inferred from mutant phenotype	17728702	RGD
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	11562372	RGD
involved in positive regulation of D-glucose import	IMP IMP: Inferred from mutant phenotype	17098211	RGD
involved in positive regulation of MAP kinase activity	IMP IMP: Inferred from mutant phenotype	16935468	RGD
involved in positive regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	12790799	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	12663471	RGD
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	10085132	RGD
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	1915352	RGD
involved in regulation of phosphorylation	IDA IDA: Inferred from direct assay	21696630	RGD
involved in response to amino acid	IEP IEP: Inferred from expression pattern	17210758	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	17728104	RGD
involved in response to glucose	IEP IEP: Inferred from expression pattern	12960081	RGD
involved in response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	12226102	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	16936002	RGD
involved in response to mechanical stimulus	IEP IEP: Inferred from expression pattern	17487266	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	11478406	RGD
involved in response to oxidative stress	IMP IMP: Inferred from mutant phenotype	11576956	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	17123493	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in postsynaptic cytosol	IDA IDA: Inferred from direct assay	8263228	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Prkcd Protein Structure

C1_nPKC_theta-like_rpt1

C1_nPKC_theta-like_rpt2

PKc_like

0
200
400
600
673 a.a.

Protein Preferred Names

Protein Names

protein kinase C delta type

nPKC-delta

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11122	PRKCD Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11123	Prkcd Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11124	Prkcd Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prkcd	NCBI	NCBI:5580

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