PRKCD - protein kinase C delta Gene

Homo sapiens

Also known as MAY1; PKCD; ALPS3; CVID9; nPKC-delta

Gene ID: 5580 | Gene type: protein coding

About PRKCD

Cytogenetic location: 3p21.1 Genomic coordinates (GRCh38): 3:53,161,209-53,192,717 (from NCBI)

This gene has 14 transcripts (splice variants), 289 orthologues, 5 paralogues and is associated with 4 phenotypes. Ubiquitous expression in adrenal (RPKM 23.1), bone marrow (RPKM 21.7) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the protein kinase C family of serine- and threonine-specific protein kinases. The encoded protein is activated by diacylglycerol and is both a tumor suppressor and a positive regulator of cell cycle progression. Also, this protein can positively or negatively regulate Apoptosis. Defects in this gene are a cause of autoimmune lymphoproliferative syndrome. [provided by RefSeq, Aug 2017]

PRKCD Products(16)

mRNA	Protein	Name
XM_047448564.1	XP_047304520.1	protein kinase C delta type isoform X1
NM_001354679.2	NP_001341608.1	protein kinase C delta type isoform c
NM_001316327.2	NP_001303256.1	protein kinase C delta type isoform c
NM_001354680.2	NP_001341609.1	protein kinase C delta type isoform c
NM_212539.2	NP_997704.1	protein kinase C delta type isoform c
NM_001354676.2	NP_001341605.1	protein kinase C delta type isoform a
NM_006254.4	NP_006245.2	protein kinase C delta type isoform c
XR_007095706.1
NM_001354678.2	NP_001341607.1	protein kinase C delta type isoform b
NM_001316327.2	NP_001303256.1	protein kinase C delta type isoform c
NM_001354676.2	NP_001341605.1	protein kinase C delta type isoform a
NM_001354678.2	NP_001341607.1	protein kinase C delta type isoform b
NM_001354679.2	NP_001341608.1	protein kinase C delta type isoform c
NM_001354680.2	NP_001341609.1	protein kinase C delta type isoform c
NM_006254.4	NP_006245.2	protein kinase C delta type isoform c
NM_212539.2	NP_997704.1	protein kinase C delta type isoform c

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables diacylglycerol-dependent serine/threonine kinase activity	EXP EXP: Inferred from Experiment	12391145	GOA
enables enzyme activator activity	IDA IDA: Inferred from direct assay	16611985	GOA
enables enzyme binding	IDA IDA: Inferred from direct assay	18556656	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	16611985	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9139733	GOA
enables protein kinase activity	IDA IDA: Inferred from direct assay	24008408	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	10713049	GOA
enables protein serine kinase activity	IDA IDA: Inferred from direct assay	17303575	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	10770950	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	17938203	GOA
involved in activation of protein kinase activity	IDA IDA: Inferred from direct assay	10713049	GOA
involved in apoptotic process	IDA IDA: Inferred from direct assay	10770950	GOA
involved in cell chemotaxis	IMP IMP: Inferred from mutant phenotype	24008408	GOA
involved in cellular response to UV	IDA IDA: Inferred from direct assay	17303575	GOA
involved in cellular response to angiotensin	IDA IDA: Inferred from direct assay	18285462	GOA
involved in cellular response to hydrogen peroxide	IDA IDA: Inferred from direct assay	10713049	GOA
involved in cellular response to hydroperoxide	IDA IDA: Inferred from direct assay	19059439	GOA
involved in cellular senescence	IMP IMP: Inferred from mutant phenotype	15282327	GOA
involved in negative regulation of MAP kinase activity	IMP IMP: Inferred from mutant phenotype	19279008	GOA
involved in negative regulation of glial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	15774464	GOA
involved in neutrophil activation	IDA IDA: Inferred from direct assay	10770950	GOA
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	18285462	GOA
involved in peptidyl-threonine phosphorylation	IDA IDA: Inferred from direct assay	10770950	GOA
involved in positive regulation of ceramide biosynthetic process	IMP IMP: Inferred from mutant phenotype	19279011	GOA
involved in positive regulation of endodeoxyribonuclease activity	IMP IMP: Inferred from mutant phenotype	19059439	GOA
involved in positive regulation of glucosylceramide catabolic process	IMP IMP: Inferred from mutant phenotype	19279011	GOA
involved in positive regulation of phospholipid scramblase activity	IMP IMP: Inferred from mutant phenotype	10770950	GOA
involved in positive regulation of protein import into nucleus	IMP IMP: Inferred from mutant phenotype	19059439	GOA
involved in positive regulation of sphingomyelin catabolic process	IMP IMP: Inferred from mutant phenotype	19279011	GOA
involved in positive regulation of superoxide anion generation	IMP IMP: Inferred from mutant phenotype	19801500	GOA
involved in post-translational protein modification	IDA IDA: Inferred from direct assay	19059439	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	10713049	GOA
involved in regulation of actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	22554282	GOA
involved in regulation of ceramide biosynthetic process	IDA IDA: Inferred from direct assay	17303575	GOA
involved in termination of signal transduction	IMP IMP: Inferred from mutant phenotype	19279008	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15632189	GOA
located in cytosol	IDA IDA: Inferred from direct assay	10770950	GOA
located in endolysosome	IDA IDA: Inferred from direct assay	17303575	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	15774464	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15632189	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	10770950	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRKCD Protein Structure

C1_1

Pkinase

Pkinase_C

0
200
400
600
676 a.a.

Protein Preferred Names

Protein Names

protein kinase C delta type

protein kinase C delta VIII

tyrosine-protein kinase PRKCD

Related Diseases

Diseases

Alias

Lymphoproliferative Syndrome 3

LPFS3	Cd70 Deficiency
Combined Immunodeficiency Due To Cd70 Deficiency	Cid Due To Cd70 Deficiency

Glioma

Diabetes Mellitus

Diabetes

Acth-Secreting Pituitary Adenoma

Acth-Producing Pituitary Adenoma	Corticotroph Adenoma
Corticotropinoma	Pituitary-Dependent Cushing'S Disease
Adrenal Gland Hyperfunction	Cushing Syndrome

Endometrial Cancer

Endometrial Carcinoma	Endometrial Neoplasm
Malignant Neoplasm Of Endometrium	Endometrioid Carcinoma
Endometrial Neoplasms	Carcinoma, Endometrioid
Endometrial Cancer, Familial	Endometrial Carcinoma, Somatic
Endometrial Cancer, Susceptibility To	Endometrial Ca
Malignant Endometrial Neoplasm	Neoplasm Of Endometrium
Primary Malignant Neoplasm Of Endometrium	Tumor Of Endometrium
Carcinoma Of The Endometrium	Endometrioid Carcinoma Of Female Reproductive System
ENDMC	Carcinoma Endometrioid
Endometrial Cancers	Cancer, Endometrial
Uterine Corpus Cancer

Lymphoproliferative Syndrome

Lymphoproliferative Disorder	Lymphoproliferative Disorders
Lymphoproliferative Disorders, Susceptibility To

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Craniometaphyseal Dysplasia, Autosomal Dominant

Craniometaphyseal Dysplasia	CMDD
Cmdj	Cmd
Autosomal Dominant Craniometaphyseal Dysplasia	Craniometaphyseal Dysplasia, Jackson Type
Craniometaphyseal Dysplasia Jackson Type	Autosomal Recessive Craniometaphyseal Dysplasia
Cmdr	Dysplasia, Craniometaphyseal, Autosomal Dominant
Craniometaphyseal Dysplasia, Autosomal Recessive Type

Autoimmune Lymphoproliferative Syndrome

ALPS	Canale-Smith Syndrome
Autoimmune Lymphoproliferative Syndrome, Type Ia	Autoimmune Lymphoproliferative Syndrome, Type Ib
Autoimmune Lymphoproliferative Syndrome Type 1, Autosomal Dominant	Css
Autoimmune Lymphoproliferative Syndrome, Type 1b	Autoimmune Lymphoproliferative Syndrome, Type 1a
Autoimmune Lymphoproliferative Syndrome, Type I, Autosomal Dominant	Fas Deficiency
Autoimmune Lymphoproliferative Syndrome 1a	ALPS1A
Autoimmune Lymphoproliferative Syndrome Type Ia	Autoimmune Lymphoproliferative Syndrome 1b
ALPS1B	Autoimmune Lymphoproliferative Syndrome Type Ib

Systemic Lupus Erythematosus 16

SLEB16	Autosomal Systemic Lupus Erythematosus
Autosomal Sle	Familial Sle
Familial Systemic Lupus Erythematosus	Lupus Erythematosus, Systemic, Type 16

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Ras-Associated Autoimmune Leukoproliferative Disorder

RALD	Autoimmune Lymphoproliferative Syndrome Type 4
Alps4	Autoimmune Lymphoproliferative Syndrome, Type Iv
Ras-Associated Autoimmune Leukoproliferative Disease	Ras-Associated Autoimmune Lymphoproliferative Syndrome Type Iv, Somatic
Alps Type 4	Alps Type Iv
Autoimmune Lymphoproliferative Syndrome Type Iv	Autoimmune Lymphoproliferative Syndrome 4

B Cell Deficiency

Immunoglobulin Heavy Chain Deficiency	B Cell Deficiencies
Immunoglobulin Heavy Chain Deletion	Humoral Immune Defect

Common Variable Immunodeficiency

Cvid	Common Variable Agammaglobulinemia
Acquired Hypogammaglobulinemia	Common Variable Immune Deficiency
Hypogamma-Globulinemia, Acquired	Idiopathic Immunoglobulin Deficiency
Primary Antibody Deficiency	Primary Hypogammaglobulinemia
Acquired Agammaglobulinemia	Sporadic Hypogammaglobulinemia
Common Variable Hypogamma-Globulinemia	Immunoglobulin Deficiency, Late-Onset
Common Variable Hypogammaglobulinemia	Immunodeficiency, Common Variable

Pheochromocytoma

Pheochromocytoma, Susceptibility To	Phaeochromocytoma
Adrenal Gland Chromaffin Paraganglioma	Adrenal Gland Chromaffinoma
Adrenal Gland Paraganglioma	Adrenal Gland Pheochromocytoma
Chromaffin Paraganglioma Of The Adrenal Gland	Intraadrenal Paraganglioma
PCC	Chromaffin Cell Tumor
Medullary Chromaffinoma	Medullary Paraganglioma
Pheochromoblastoma	Pheochromocytomas
Chromaffin Cell Neoplasm	Pheochromocytoma, Malignant

Ventricular Tachycardia, Catecholaminergic Polymorphic, 2

Catecholaminergic Polymorphic Ventricular Tachycardia 2	CPVT2
Vtsip	Bidirectional Tachycardia
Stress-Induced Polymorphic Ventricular Tachycardia	Ventricular Tachycardia, Stress-Induced Polymorphic
Cvpt2	Double Tachycardia Induced By Catecholamines
Malignant Paroxysmal Ventricular Tachycardia	Multifocal Ventricular Premature Beats
Paroxysmal Ventricular Fibrillation	Syncopal Paroxysmal Tachycardia
Syncopal Tachyarythmia	Tachycardia, Ventricular, Catecholaminergic Polymorphic, Type 2
Ventricular Tachycardia, Catecholaminergic Polymorphic, 1	Multifocal Pvcs
Multifocal Premature Ventricular Beats	Paroxysmal Familial Ventricular Fibrillation

Spinocerebellar Ataxia 10

Spinocerebellar Ataxia Type 10	SCA10
Spinocerebellar Ataxia-10	Ataxia, Spinocerebellar, Type 10

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Hepatomas
Liver Neoplasm	Liver Carcinoma
Liver And Intrahepatic Biliary Tract Carcinoma	Malignant Hepatobiliary Neoplasm
Adult Primary Hepatocellular Carcinoma	Hepatoblastoma
Carcinoma Of Liver	Malignant Liver Tumour
Malignant Hepatic Tumour

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

Leukemia, Chronic Myeloid

Chronic Myeloid Leukemia	Chronic Myelogenous Leukemia
CML	Chronic Granulocytic Leukemia
Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib	Chronic Myeloid Leukaemia
Chronic Granulocytic Leukaemia	Chronic Myelogenous Leukaemia
Myeloid Leukemia, Chronic	Leukemia, Chronic Myelogenous
Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic	Cml - Chronic Myelogenous Leukemia
Cgl	Chronic Myelocytic Leukemia
Leukemia, Chronic Myeloid, Atypical	ACML
Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative	Myeloid Leukemia Chronic
Leukemia, Myeloid, Chronic	Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative
Cml- [Chronic Myeloid Leukaemia]	Cgl - [Chronic Granulocytic Leukaemia]
Chronic Myelocytic Leukaemia

Breast Cancer

Breast Carcinoma	Breast Cancer, Familial
Malignant Neoplasm Of Breast	Male Breast Cancer
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Autoimmune Lymphoproliferative Syndrome, Type Iii

ALPS3	Autoimmune Lymphoproliferative Syndrome Type 3
Cvid9	Immunodeficiency, Common Variable, 9, Formerly
Cvid9, Formerly	Autoimmune Lymphoproliferative Syndrome Type Iii
Common Variable Immunodeficiency 9	Autoimmune Lymphoproliferative Syndrome 3
Immunodeficiency, Common Variable, 9	Type 3 Autoimmune Lymphoproliferative Syndrome
Immunodeficiency, Variable, Common, Type 9

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11122	PRKCD Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11123	Prkcd Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11124	Prkcd Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PRKCD	VGNC	VGNC:33329
Canis familiaris	PRKCD	VGNC	VGNC:44979
Mus musculus	PRKCD	MGD	MGI:97598
Macaca mulatta	PRKCD	VGNC	VGNC:76411
Rattus norvegicus	PRKCD	RGD	RGD:67383
Felis catus	PRKCD	VGNC	VGNC:69058
Others	PRKCD	NCBI

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