GPHA2 - glycoprotein hormone subunit alpha 2 Gene

Homo sapiens

Also known as A2; GPA2; ZSIG51

Gene ID: 170589 | Gene type: protein coding

About GPHA2

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:64,934,471-64,937,708 (from NCBI)

This gene has 3 transcripts (splice variants) and 181 orthologues. Biased expression in pancreas (RPKM 14.6), testis (RPKM 3.2) and 2 other tissues.

Summary

GPHA2 is a cystine knot-forming polypeptide and a subunit of the dimeric glycoprotein hormone family (Hsu et al., 2002 [PubMed 12089349]).[supplied by OMIM, Mar 2008]

GPHA2 Products(1)

mRNA	Protein	Name
NM_130769.4	NP_570125.1	glycoprotein hormone alpha-2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12045258	GOA
enables protein heterodimerization activity	IDA IDA: Inferred from direct assay	12045258	GOA
enables thyrotropin-releasing hormone receptor binding	IMP IMP: Inferred from mutant phenotype	12045258	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	12045258	GOA
involved in cell surface receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	12045258	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular region	IDA IDA: Inferred from direct assay	12089349	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

glycoprotein hormone alpha-2

cysteine knot protein

Recombinant GPHA2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76958	GPHA2 Protein, Human (HEK293, His)	Q96T91 (Q24-Y129)	≥95%
HY-P76959	GPHA2 Protein, Human (HEK293, Fc)	Q96T91 (Q24-Y129)	≥95%

Related Diseases

Diseases

Alias

Salt And Pepper Syndrome

Salt & Pepper Syndrome

Salt-And-Pepper Syndrome

Voyeurism

Norrie Disease

Atrophia Bulborum Hereditaria	Episkopi Blindness
Pseudoglioma	ND
Norrie-Warburg Disease	Anderson-Warburg Syndrome
Fetal Iritis Syndrome	Norrie Syndrome
Norrie-Warburg Syndrome	Ndp
Congenital Progressive Oculo-Acoustico-Cerebral Degeneration	Norrie'S Disease
Oligophrenia Microphthalmus	Pseudoglioma Congenita
Whitnall-Norman Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05637	GPHA2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	GPHA2	VGNC	VGNC:29533
Macaca mulatta	GPHA2	VGNC	VGNC:72961
Felis catus	GPHA2	VGNC	VGNC:62664
Rattus norvegicus	GPHA2	RGD	RGD:621748
Mus musculus	GPHA2	MGD	MGI:2156541
Others	GPHA2	NCBI

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