Map2k1 - mitogen activated protein kinase kinase 1 Gene

Rattus norvegicus

Also known as Mek1

Gene ID: 170851 | Gene type: protein coding

About Map2k1

Primary_assembly 8: 64,683,449-64,755,147 reverse strand.mRatBN7.2:CM026981.1

This gene has 5 transcripts (splice variants), 211 orthologues, 8 paralogues and is associated with 38 phenotypes. Biased expression in Brain (RPKM 58.), Muscle (RPKM 31.3) and 9 other tissues.

Summary

Enables ATP binding activity; MAP kinase kinase activity; and Enzyme binding activity. Involved in several processes, including establishment of vesicle localization; regulation of gene expression; and regulation of intracellular signal transduction. Acts upstream of or within positive regulation of Ras protein signal transduction. Located in several cellular components, including dendrite cytoplasm; perikaryon; and perinuclear region of cytoplasm. Is active in glutamatergic synapse and postsynaptic density. Colocalizes with microtubule. Used to study cataract and prostate adenocarcinoma. Human ortholog(s) of this gene implicated in carcinoma (multiple); cardiofaciocutaneous syndrome 3; high grade glioma; and melorheostosis. Orthologous to human MAP2K1 (mitogen-activated protein kinase kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Map2k1 Products(1)

mRNA	Protein	Name
NM_031643.4	NP_113831.1	dual specificity mitogen-activated protein kinase kinase 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	7611406	RGD
enables MAP kinase kinase activity	IDA IDA: Inferred from direct assay	7611406	RGD
enables mitogen-activated protein kinase kinase kinase binding	IDA IDA: Inferred from direct assay	7565670	RGD
enables mitogen-activated protein kinase kinase kinase binding	IPI IPI: Inferred from physical interaction	16006144	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	16272159	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	15917294	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	15917294	RGD
enables small GTPase binding	IPI IPI: Inferred from physical interaction	7935430	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in Golgi inheritance	IMP IMP: Inferred from mutant phenotype	9458043	RGD
involved in melanosome transport	IDA IDA: Inferred from direct assay	15753041	RGD
involved in negative regulation of gene expression	IGI IGI: Inferred from genetic interaction	28947594	RGD
involved in negative regulation of homotypic cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	17183546	RGD
involved in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway	IGI IGI: Inferred from genetic interaction	15459207	RGD
involved in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	15459207	RGD
involved in neuron differentiation	IMP IMP: Inferred from mutant phenotype	17202850	RGD
involved in neuron projection morphogenesis	IMP IMP: Inferred from mutant phenotype	17202850	RGD
involved in positive regulation of ATP biosynthetic process	IGI IGI: Inferred from genetic interaction	15459207	RGD
involved in positive regulation of ATP biosynthetic process	IMP IMP: Inferred from mutant phenotype	15459207	RGD
involved in positive regulation of GTPase activity	IMP IMP: Inferred from mutant phenotype	17183546	RGD
involved in positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	7935430	RGD
acts upstream of or within positive regulation of Ras protein signal transduction	IMP IMP: Inferred from mutant phenotype	19029245	RGD
involved in positive regulation of autophagy	IDA IDA: Inferred from direct assay	26581593	RGD
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	17183546	RGD
involved in positive regulation of gene expression	IGI IGI: Inferred from genetic interaction	15459207	RGD
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	15459207	RGD
involved in positive regulation of muscle contraction	IGI IGI: Inferred from genetic interaction	15459207	RGD
involved in positive regulation of muscle contraction	IMP IMP: Inferred from mutant phenotype	15459207	RGD
involved in positive regulation of transcription elongation by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18086894	RGD
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	7565670	RGD
involved in regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	26581593	RGD
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	EXP EXP: Inferred from Experiment	12202034	RGD
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IDA IDA: Inferred from direct assay	12202034	RGD
involved in regulation of vascular associated smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	10198244	RGD
involved in response to axon injury	IMP IMP: Inferred from mutant phenotype	15737734	RGD
involved in response to glucocorticoid	IDA IDA: Inferred from direct assay	11872750	RGD
involved in response to oxidative stress	IDA IDA: Inferred from direct assay	16481589	RGD
involved in triglyceride homeostasis	IDA IDA: Inferred from direct assay	26581593	RGD
involved in vesicle transport along microtubule	IDA IDA: Inferred from direct assay	15753041	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	9714150	RGD
located in cell cortex	IDA IDA: Inferred from direct assay	16272159	RGD
located in dendrite	IDA IDA: Inferred from direct assay	10465442	RGD
located in dendrite cytoplasm	IDA IDA: Inferred from direct assay	9714150	RGD
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	12202034	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	12202034	RGD
located in microtubule	IDA IDA: Inferred from direct assay	10465442	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	9714150	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	12876277	RGD
is active in postsynaptic density	IDA IDA: Inferred from direct assay	7478291	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Map2k1 Protein Structure

PKc_MEK1

0
100
200
300
393 a.a.

Protein Preferred Names

Protein Names

dual specificity mitogen-activated protein kinase kinase 1

ERK activator kinase 1	MAP kinase kinase 1
MAP kinase/Erk kinase 1	MAPK/ERK kinase 1
MAPKK 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-136848	SM1-71	Inhibitor	96.09%	Unkown
HY-RS08033	MAP2K1 Human Pre-designed siRNA Set A		/	Unkown
HY-RS08034	Map2k1 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS08035	Map2k1 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Map2k1	NCBI	NCBI:5604
Mus musculus	Map2k1	NCBI	NCBI:26395

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