2. Gene
  3. Ctsd - cathepsin D Gene

Ctsd - cathepsin D Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 171293 | Gene type: protein coding

About Ctsd

Primary_assembly 1: 197,527,467-197,539,488 reverse strand.mRatBN7.2:CM026974.1

This gene has 3 transcripts (splice variants), 211 orthologues, 8 paralogues and is associated with 21 phenotypes.

Summary

Enables endopeptidase activity and peptide binding activity. Involved in proteolysis and response to nutrient levels. Located in lysosome. Human ortholog(s) of this gene implicated in Alzheimer's disease; breast cancer; and neuronal ceroid lipofuscinosis 10. Orthologous to human CTSD (Cathepsin D). [provided by Alliance of Genome Resources, Apr 2022]

Ctsd Products(1)

mRNA Protein Name
NM_134334.3 NP_599161.2 cathepsin D precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables endopeptidase activity IDA
IDA: Inferred from direct assay
8702598 RGD
enables endopeptidase activity IMP
IMP: Inferred from mutant phenotype
8717430 RGD
enables peptide binding IDA
IDA: Inferred from direct assay
8702598 RGD
Biological Process GO Annotation Evidence Reference Source
involved in protein catabolic process IDA
IDA: Inferred from direct assay
12666874 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
17665967 RGD
involved in synaptic vesicle endosomal processing IDA
IDA: Inferred from direct assay
31340140 RGD
involved in synaptic vesicle endosomal processing IMP
IMP: Inferred from mutant phenotype
31340140 RGD
involved in vesicle-mediated transport in synapse IDA
IDA: Inferred from direct assay
31340140 RGD
involved in vesicle-mediated transport in synapse IMP
IMP: Inferred from mutant phenotype
31340140 RGD
Cellular Component GO Annotation Evidence Reference Source
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
31340140 RGD
is active in GABA-ergic synapse IMP
IMP: Inferred from mutant phenotype
31340140 RGD
is active in presynaptic endosome IDA
IDA: Inferred from direct assay
31340140 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cathepsin D

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-137978A Ezurpimtrostat hydrochloride Inhibitor 99.29% Phase 2
HY-137978 Ezurpimtrostat / Phase 2
Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03328 CTSD Human Pre-designed siRNA Set A / Unkown
HY-RS03329 Ctsd Mouse Pre-designed siRNA Set A / Unkown
HY-P2750 Cathepsin D / Unkown
HY-RS03330 Ctsd Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ctsd NCBI NCBI:1509
Mus musculus Ctsd NCBI NCBI:13033