2. Gene
  3. Mag - myelin-associated glycoprotein Gene

Mag - myelin-associated glycoprotein Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Gma; siglec-4a

Gene ID: 17136 | Gene type: protein coding

About Mag

Summary

This gene encodes a type I membrane protein and member of the immunoglobulin-like superfamily. It is expressed in myelinating glial cells, including oligodendrocytes of the central nervous system and Schwann cells of the peripheral nervous system. Mice lacking the encoded protein express abundant myelin, but suffer long-term axon degeneration, altered distribution of channels and adhesion molecules at nodes of Ranvier, and altered axon cytoskeletal structure. While not required for myelination, the encoded protein enhances axon-myelin stability, helps to structure nodes of Ranvier, and regulates the axon Cytoskeleton. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

Mag Products(8)

mRNA Protein Name
NM_001346084.1 NP_001333013.1 myelin-associated glycoprotein isoform 1 precursor
NM_001346085.1 NP_001333014.1 myelin-associated glycoprotein isoform 1 precursor
NM_001346086.1 NP_001333015.1 myelin-associated glycoprotein isoform 3 precursor
NM_001346087.1 NP_001333016.1 myelin-associated glycoprotein isoform 3 precursor
NM_001346088.1 NP_001333017.1 myelin-associated glycoprotein isoform 3 precursor
NM_001346089.1 NP_001333018.1 myelin-associated glycoprotein isoform 2 precursor
NM_001369262.1 NP_001356191.1 myelin-associated glycoprotein isoform 1 precursor
NM_010758.3 NP_034888.1 myelin-associated glycoprotein isoform 3 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables ganglioside GT1b binding IMP
IMP: Inferred from mutant phenotype
27922006 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12839991 MGI
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
27922006 MGI
enables sialic acid binding IDA
IDA: Inferred from direct assay
27922006 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within axon regeneration IGI
IGI: Inferred from genetic interaction
20731761 MGI
involved in central nervous system myelin formation IGI
IGI: Inferred from genetic interaction
31641127 MGI
involved in central nervous system myelination IMP
IMP: Inferred from mutant phenotype
9482783 MGI
involved in myelination IGI
IGI: Inferred from genetic interaction
31641127 MGI
involved in myelination IMP
IMP: Inferred from mutant phenotype
31641127 MGI
involved in negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
26335717 MGI
involved in negative regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
17640868 MGI
involved in positive regulation of myelination IMP
IMP: Inferred from mutant phenotype
10625334 MGI
acts upstream of or within transmission of nerve impulse IMP
IMP: Inferred from mutant phenotype
20071523 MGI
Cellular Component GO Annotation Evidence Reference Source
located in Schmidt-Lanterman incisure IDA
IDA: Inferred from direct assay
12975355 MGI
located in myelin sheath IDA
IDA: Inferred from direct assay
11283023 MGI
located in myelin sheath adaxonal region IDA
IDA: Inferred from direct assay
12718855 MGI
located in paranode region of axon IDA
IDA: Inferred from direct assay
12975355 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
9482783 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

myelin-associated glycoprotein

Recombinant Mag Proteins

Cat. No. Product Name Accession Purity
HY-P70319 MAG/Siglec-4a Protein, Mouse (HEK293, His) P20917 (G20-P516) ≥95%
HY-P70319A MAG/Siglec-4a Protein, Mouse (HEK293, His, solution) P20917 (G20-P516) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (13)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-D1498 Mag-Fluo-4 AM ≥96.0% Unkown
HY-101898 Indo-1 AM ≥96.0% Unkown
HY-136924 FP-Biotin 99.84% Unkown
HY-10865 LY2183240 Inhibitor 98.01% Unkown
HY-146081 CD22 ligand-1 / Unkown
HY-D1700 Mag-indo-1/AM / Unkown
HY-D1701 Mag-Fura-2 AM / Unkown
HY-D1702 Mag-Fura-2 tetrapotassium / Unkown
HY-RS07963 MAG Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS07976 MAGED1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS07977 MAGED2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W127843 Mag-Indo-1 tetrapotassium salt / Unkown
HY-P10369 Betiatide / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mag NCBI NCBI:4099
Rattus norvegicus Mag NCBI NCBI:29409