Mdk - midkine Gene

Mus musculus

Also known as MK; Mek

Gene ID: 17242 | Gene type: protein coding

About Mdk

Summary

This gene encodes a secreted growth factor that belongs to the pleiotrophin/midkine heparin-binding protein family and functions in a variety of biological processes. The encoded cytokine promotes the growth, differentiation, survival and migration of several target cells including leucocytes involved in inflammation. This protein plays a role in the formation of scar tissue and intraperitoneal adhesions, and promotes neurite outgrowth and neuron survival. The protein encoded by this gene is associated with obesity and inhibition of Insulin signaling in fat cells. A pseudogene of this gene is present on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

Mdk Products(6)

mRNA	Protein	Name
NM_001012335.3	NP_001012335.1	midkine isoform a precursor
NM_001012336.3	NP_001012336.1	midkine isoform a precursor
NM_001291481.2	NP_001278410.1	midkine isoform a precursor
NM_001291482.2	NP_001278411.1	midkine isoform b
NM_001291483.2	NP_001278412.1	midkine isoform c precursor
NM_010784.6	NP_034914.1	midkine isoform a precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables chondroitin sulfate binding	IDA IDA: Inferred from direct assay	10978312	MGI
enables heparin binding	IDA IDA: Inferred from direct assay	10978312	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9089390	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in T cell activation involved in immune response	IMP IMP: Inferred from mutant phenotype	28183532	MGI
involved in behavioral fear response	IMP IMP: Inferred from mutant phenotype	10096022	MGI
involved in cerebellar granular layer development	IMP IMP: Inferred from mutant phenotype	10096022	MGI
involved in cerebral cortex development	IEP IEP: Inferred from expression pattern	10096022	MGI
involved in cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	16901907	MGI
involved in defecation	IMP IMP: Inferred from mutant phenotype	10096022	MGI
involved in dentate gyrus development	IEP IEP: Inferred from expression pattern	10096022	MGI
involved in estrous cycle	IMP IMP: Inferred from mutant phenotype	17121547	MGI
involved in glial cell projection elongation	IDA IDA: Inferred from direct assay	16901907	MGI
involved in hippocampus development	IMP IMP: Inferred from mutant phenotype	10096022	MGI
involved in leukocyte chemotaxis involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	10683378	MGI
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	21185956	MGI
involved in negative regulation of cardiac muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	17015789	MGI
involved in negative regulation of cell adhesion	IDA IDA: Inferred from direct assay	10978312	MGI
involved in negative regulation of epithelial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	15509530	MGI
involved in negative regulation of inflammatory response to wounding	IMP IMP: Inferred from mutant phenotype	17015789	MGI
involved in negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	17230638	MGI
involved in negative regulation of ossification	IMP IMP: Inferred from mutant phenotype	20200993	MGI
involved in oogenesis	IMP IMP: Inferred from mutant phenotype	17121547	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	10096022	MGI
involved in positive regulation of T cell differentiation	IMP IMP: Inferred from mutant phenotype	28183532	MGI
involved in positive regulation of artery morphogenesis	IMP IMP: Inferred from mutant phenotype	29233575	MGI
involved in positive regulation of cartilage development	IMP IMP: Inferred from mutant phenotype	25551381	MGI
involved in positive regulation of hepatocyte proliferation	IMP IMP: Inferred from mutant phenotype	15482347	MGI
involved in positive regulation of inflammatory response to wounding	IMP IMP: Inferred from mutant phenotype	24458438	MGI
involved in positive regulation of leukocyte adhesion to vascular endothelial cell	IMP IMP: Inferred from mutant phenotype	24458438	MGI
involved in positive regulation of leukocyte chemotaxis	IMP IMP: Inferred from mutant phenotype	15482347	MGI
involved in positive regulation of macrophage chemotaxis	IMP IMP: Inferred from mutant phenotype	10683378	MGI
involved in positive regulation of neural precursor cell proliferation	IMP IMP: Inferred from mutant phenotype	17230638	MGI
involved in positive regulation of neutrophil chemotaxis	IMP IMP: Inferred from mutant phenotype	15509530	MGI
involved in positive regulation of neutrophil extravasation	IMP IMP: Inferred from mutant phenotype	24458438	MGI
involved in positive regulation of substrate adhesion-dependent cell spreading	IMP IMP: Inferred from mutant phenotype	16901907	MGI
involved in positive regulation of vascular endothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	29233575	MGI
involved in regulation of behavior	IMP IMP: Inferred from mutant phenotype	10096022	MGI
involved in regulation of bone remodeling	IMP IMP: Inferred from mutant phenotype	21185956	MGI
involved in regulation of chondrocyte differentiation	IMP IMP: Inferred from mutant phenotype	25551381	MGI
involved in response to auditory stimulus	IMP IMP: Inferred from mutant phenotype	16619002	MGI
involved in response to wounding	IDA IDA: Inferred from direct assay	10683378	MGI
involved in short-term memory	IMP IMP: Inferred from mutant phenotype	10096022	MGI
involved in tissue regeneration	IMP IMP: Inferred from mutant phenotype	15482347	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

midkine

retanoic acid-responsive protein	retinoic acid-induced differentiation factor
retinoic acid-responsive protein

Recombinant Mdk Proteins

Cat. No.	Product Name	Accession	Purity
HY-P79419	Midkine Protein, Mouse	P12025 (K23-D140)	≥95%
HY-P700223AF	Animal-Free Midkine Protein, Mouse (His)	P12025 (K23-D140)	≥95%
HY-P701025	MDK/Midkine Protein, Mouse (His)	P12025 (K23-D140)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-110171	iMDK	Inhibitor	99.35%	Unkown
HY-110171A	iMDK quarterhydrate	Inhibitor	99.34%	Unkown
HY-18633	MDK83190	Activator	98.40%	Unkown
HY-119467	MDK0734		/	Unkown
HY-RS08262	MDK Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mdk	NCBI	NCBI:4192
Rattus norvegicus	Mdk	NCBI	NCBI:81517

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