MDK - midkine Gene

Homo sapiens

Also known as MK; ARAP; NEGF2

Gene ID: 4192 | Gene type: protein coding

About MDK

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:46,380,784-46,383,837 (from NCBI)

This gene has 12 transcripts (splice variants), 247 orthologues and 1 paralogue. Broad expression in ovary (RPKM 88.5), endometrium (RPKM 55.5) and 14 other tissues.

Summary

This gene encodes a member of a small family of secreted growth factors that binds heparin and responds to retinoic acid. The encoded protein promotes cell growth, migration, and angiogenesis, in particular during tumorigenesis. This gene has been targeted as a therapeutic for a variety of different disorders. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]

MDK Products(6)

mRNA	Protein	Name
NM_001012333.3	NP_001012333.1	midkine isoform a precursor
NM_001012334.2	NP_001012334.1	midkine isoform a precursor
NM_001270550.1	NP_001257479.1	midkine isoform a precursor
NM_001270551.3	NP_001257480.1	midkine isoform a precursor
NM_001270552.3	NP_001257481.1	midkine isoform b precursor
NM_002391.6	NP_002382.1	midkine isoform a precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables heparan sulfate binding	IDA IDA: Inferred from direct assay	12084985	GOA
enables heparin binding	IDA IDA: Inferred from direct assay	9384573	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10212223	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	18469519	GOA
involved in leukocyte chemotaxis involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	10683378	GOA
involved in negative regulation of cardiac muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	19060126	GOA
involved in negative regulation of neuron apoptotic process	IDA IDA: Inferred from direct assay	12573468	GOA
involved in negative regulation of regulatory T cell differentiation	IMP IMP: Inferred from mutant phenotype	22323540	GOA
involved in positive regulation of blood vessel branching	IMP IMP: Inferred from mutant phenotype	19060126	GOA
involved in positive regulation of cell adhesion	IDA IDA: Inferred from direct assay	12084985	GOA
involved in positive regulation of cell migration	IDA IDA: Inferred from direct assay	15466886	GOA
involved in positive regulation of epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	18469519	GOA
involved in positive regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	22323540	GOA
involved in positive regulation of interleukin-12 production	IMP IMP: Inferred from mutant phenotype	22323540	GOA
involved in positive regulation of keratinocyte proliferation	IDA IDA: Inferred from direct assay	18469519	GOA
involved in positive regulation of leukocyte cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	24458438	GOA
involved in positive regulation of macrophage chemotaxis	IMP IMP: Inferred from mutant phenotype	10683378	GOA
involved in positive regulation of neuron migration	IMP IMP: Inferred from mutant phenotype	10212223	GOA
involved in positive regulation of neuron projection development	IDA IDA: Inferred from direct assay	12084985	GOA
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	15466886	GOA
involved in positive regulation of oligodendrocyte differentiation	IDA IDA: Inferred from direct assay	27445335	GOA
involved in positive regulation of smooth muscle cell chemotaxis	IMP IMP: Inferred from mutant phenotype	10683378	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MDK Protein Structure

PTN_MK_N

PTN_MK_C

0
100
143 a.a.

Protein Preferred Names

Protein Names

midkine

amphiregulin-associated protein

MDK Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MDK	P21741	TMED8	Homo sapiens	Q6PL24	Validated Y2H	32296183
Intra	MDK	P21741	MIEF2	Homo sapiens	Q96C03-3	Validated Y2H	32296183
Intra	MDK	P21741	JOSD2	Homo sapiens	Q8TAC2	Validated Y2H	32296183
Intra	MDK	P21741	RBFA	Homo sapiens	Q8N0V3	Validated Y2H	32296183
Intra	MDK	P21741	AP1M1	Homo sapiens	Q9BXS5	Validated Y2H	32296183
Intra	MDK	P21741	TCEA2	Homo sapiens	Q15560	Validated Y2H	32296183
Intra	MDK	P21741	NFU1	Homo sapiens	Q9UMS0	Validated Y2H	32296183
Intra	MDK	P21741	PBX3	Homo sapiens	Q96AL5	Validated Y2H	32296183
Intra	MDK	P21741	UBQLN1	Homo sapiens	Q9UMX0	Y2H Prey Pooling	32296183
Intra	MDK	P21741	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32296183
Intra	MDK	P21741	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	32296183
Intra	MDK	P21741	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MDK Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73295	MDK Protein, Human (sf9)	P21741-1 (V21-D143)	≥95%
HY-P700138AF	Animal-Free MDK Protein, Human (His)	P21741-1 (V21-D143)	≥95%
HY-P700791	MDK/Midkine Protein, Human (His-Avi)	P21741-1 (V21-D143)	≥95%
HY-P701024	MDK/Midkine Protein, Human (Biotinylated, His-Avi)	P21741-1 (V21-D143)	≥95%

Related Diseases

Diseases

Alias

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Neuroblastoma

Nb	Neuroblastoma, Susceptibility To
Neuroblastomas	Central Neuroblastoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-110171	iMDK	Inhibitor	99.35%	Unkown
HY-110171A	iMDK quarterhydrate	Inhibitor	99.34%	Unkown
HY-18633	MDK83190	Activator	98.40%	Unkown
HY-RS08262	MDK Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-119467	MDK0734		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MDK	RGD	RGD:69073
Mus musculus	MDK	MGD	MGI:96949
Felis catus	MDK	VGNC	VGNC:68222
Bos taurus	MDK	VGNC	VGNC:49556
Others	MDK	NCBI

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