2. Gene
  3. Mertk - MER proto-oncogene tyrosine kinase Gene

Mertk - MER proto-oncogene tyrosine kinase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Eyk; Mer; Nyk; nmf12

Gene ID: 17289 | Gene type: protein coding

About Mertk

Summary

Predicted to enable transmembrane receptor protein tyrosine kinase activity. Acts upstream of or within several processes, including animal organ development; neutrophil clearance; and protein kinase B signaling. Predicted to be located in several cellular components, including extracellular space; photoreceptor outer segment; and rhabdomere. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; immune system; and retina. Human ortholog(s) of this gene implicated in retinitis pigmentosa 38. Orthologous to human MERTK (Mer proto-oncogene, tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Mertk Products(1)

mRNA Protein Name
NM_008587.2 NP_032613.1 tyrosine-protein kinase Mer precursor
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within apoptotic cell clearance IDA
IDA: Inferred from direct assay
29440417 MGI
acts upstream of or within apoptotic cell clearance IGI
IGI: Inferred from genetic interaction
18159085 MGI
acts upstream of or within apoptotic cell clearance IMP
IMP: Inferred from mutant phenotype
17442946 MGI
involved in apoptotic cell clearance IMP
IMP: Inferred from mutant phenotype
18159085 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
15650770 MGI
acts upstream of lymphocyte activation IGI
IGI: Inferred from genetic interaction
11452127 MGI
acts upstream of or within natural killer cell differentiation IGI
IGI: Inferred from genetic interaction
16751775 MGI
acts upstream of or within negative regulation of cytokine production IGI
IGI: Inferred from genetic interaction
23878224 MGI
acts upstream of or within negative regulation of lymphocyte activation IGI
IGI: Inferred from genetic interaction
11452127 MGI
acts upstream of or within neutrophil clearance IGI
IGI: Inferred from genetic interaction
23878224 MGI
acts upstream of or within platelet activation IMP
IMP: Inferred from mutant phenotype
15650770 MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
IGI: Inferred from genetic interaction
15650770 MGI
acts upstream of or within retina development in camera-type eye IMP
IMP: Inferred from mutant phenotype
21052544 MGI
acts upstream of or within secretion by cell IMP
IMP: Inferred from mutant phenotype
15650770 MGI
acts upstream of or within spermatogenesis IGI
IGI: Inferred from genetic interaction
10227296 MGI
acts upstream of or within substrate adhesion-dependent cell spreading IMP
IMP: Inferred from mutant phenotype
15650770 MGI
acts upstream of or within vagina development IGI
IGI: Inferred from genetic interaction
18393392 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tyrosine-protein kinase Mer

Tyro 12

c-mer proto-oncogene tyrosine kinase

proto-oncogene c-Mer

proto-oncogene tyrosine-protein kinase Mer

receptor tyrosine kinase MerTK

Recombinant Mertk Proteins

Cat. No. Product Name Accession Purity
HY-P73289 Mer Protein, Mouse (sf9, His-GST) Q60805 (E573-Y867) ≥95%
HY-P73820 Mer Protein, Mouse (HEK293, Fc) Q60805 (M1-F498) ≥95%
HY-P700446 MERTK Protein, Mouse (HEK293, His) Q60805 (G19-M497) ≥95%

Related Agents

Clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-15514 Merestinib Inhibitor 99.99% Phase 2
HY-101549 MRX-2843 Inhibitor 99.70% Phase 2
HY-15514A Merestinib dihydrochloride Inhibitor 99.36% Phase 2
Pre-clinical Phase
Bioactive Molecules (12)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12344 UNC2025 Inhibitor 99.83% Unkown
HY-125510 UNC2541 Inhibitor 99.71% Unkown
HY-12344A UNC2025 hydrochloride Inhibitor 99.87% Unkown
HY-132200 UNC5293 Inhibitor 95.07% Unkown
HY-117548 UNC1062 Inhibitor 99.48% Unkown
HY-124502 UNC4203 Inhibitor 99.80% Unkown
HY-131909 CJ-2360 Inhibitor / Unkown
HY-162406 UNC8969 / Unkown
HY-162940 MerTK/Axl-IN-1 Inhibitor / Unkown
HY-169208 MerTK-IN-1 Inhibitor / Unkown
HY-RS08340 MERTK Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-101549A MRX-2843 hydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mertk NCBI NCBI:10461
Macaca fascicularis Mertk NCBI NCBI:102143798
Rattus norvegicus Mertk NCBI NCBI:65037