2. Protein Tyrosine Kinase/RTK
  3. TAM Receptor Anaplastic lymphoma kinase (ALK) FLT3
  4. UNC5293

UNC5293 is a MERTK-selective and potent inhibitor (Ki=190 pM). UNC5293 inhibits MERTK (IC50=0.9 nM) and is more selective over Axl, Tyro3 and Flt3. UNC5293 exhibits excellent mouse PK properties and is used for bone marrow leukemia research.

For research use only. We do not sell to patients.

UNC5293 Chemical Structure

UNC5293 Chemical Structure

CAS No. : 2226789-82-6

Size Price Stock Quantity
5 mg USD 265 In-stock
10 mg USD 425 In-stock
25 mg USD 850 In-stock
50 mg USD 1360 In-stock
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Based on 1 publication(s) in Google Scholar

UNC5293 Related Antibodies

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Description

UNC5293 is a MERTK-selective and potent inhibitor (Ki=190 pM). UNC5293 inhibits MERTK (IC50=0.9 nM) and is more selective over Axl, Tyro3 and Flt3. UNC5293 exhibits excellent mouse PK properties and is used for bone marrow leukemia research[1].

IC50 & Target

Axl

 

Tyro3

 

In Vitro

UNC5293?provides selective target inhibition in cell-based assays. In cultures of the human B-cell?acute lymphoblastic leukemia?(B-ALL) cell line,?UNC5293 inhibits phosphorylation of MERTK with an IC50?of 9.4?nM.?In the SEM B-ALL cell line, UNC5293 is less potent against FLT3, with an IC50?of 170?nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

UNC5293 Related Antibodies
In Vivo

UNC5293 (oral administration; 120?mg/kg; single dose) effectively inhibit MERTK?in?vivo in orthotopic 697?B-ALL mice xenografts[1].
UNC5293 (oral gavage; 3 mg/kg; single dose) has excellent mouse PK properties (7.8 h half-life and 58% oral bioavailability), and the Cmax and AUClast are 9.2 μM and 2.5 h*μM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

518.69

Formula

C30H42N6O2
CAS No.
Appearance

Viscous Liquid

Color

Colorless to light yellow

SMILES

O=C(C1=CC(C)=NC(C)=C1)N2CCC(C3=CN([C@H]4CC[C@H](O)CC4)C5=NC(N[C@@H](C)CCC)=NC=C53)CC2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (192.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9279 mL 9.6397 mL 19.2793 mL
5 mM 0.3856 mL 1.9279 mL 3.8559 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (4.82 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (4.82 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9279 mL 9.6397 mL 19.2793 mL 48.1983 mL
5 mM 0.3856 mL 1.9279 mL 3.8559 mL 9.6397 mL
10 mM 0.1928 mL 0.9640 mL 1.9279 mL 4.8198 mL
15 mM 0.1285 mL 0.6426 mL 1.2853 mL 3.2132 mL
20 mM 0.0964 mL 0.4820 mL 0.9640 mL 2.4099 mL
25 mM 0.0771 mL 0.3856 mL 0.7712 mL 1.9279 mL
30 mM 0.0643 mL 0.3213 mL 0.6426 mL 1.6066 mL
40 mM 0.0482 mL 0.2410 mL 0.4820 mL 1.2050 mL
50 mM 0.0386 mL 0.1928 mL 0.3856 mL 0.9640 mL
60 mM 0.0321 mL 0.1607 mL 0.3213 mL 0.8033 mL
80 mM 0.0241 mL 0.1205 mL 0.2410 mL 0.6025 mL
100 mM 0.0193 mL 0.0964 mL 0.1928 mL 0.4820 mL
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UNC5293 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UNC52932226789-82-6UNC 5293UNC-5293TAM ReceptorAnaplastic lymphoma kinase (ALK)FLT3Tyro3AxlMerAnaplastic lymphoma kinaseALK tyrosine kinase receptorCD246Cluster of differentiation 246Cluster of differentiation antigen 135CD135Fms like tyrosine kinase 3MERTKCancerimmunotherapyFlt3bone marrowleukemiaInhibitorinhibitorinhibit

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