2. Gene
  3. Mertk - MER proto-oncogene, tyrosine kinase Gene

Mertk - MER proto-oncogene, tyrosine kinase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as rdy

Gene ID: 65037 | Gene type: protein coding

About Mertk

Summary

Predicted to enable transmembrane receptor protein tyrosine kinase activity. Involved in phagocytosis; positive regulation of phagocytosis; and protein phosphorylation. Located in photoreceptor outer segment. Used to study retinal degeneration. Human ortholog(s) of this gene implicated in retinitis pigmentosa 38. Orthologous to human MERTK (Mer proto-oncogene, tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Mertk Products(1)

mRNA Protein Name
NM_022943.1 NP_075232.1 tyrosine-protein kinase Mer precursor
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in phagocytosis IDA
IDA: Inferred from direct assay
11861639 RGD
involved in phagocytosis IMP
IMP: Inferred from mutant phenotype
11861639 RGD
involved in positive regulation of phagocytosis IDA
IDA: Inferred from direct assay
11592982 RGD
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
11861639 RGD
Cellular Component GO Annotation Evidence Reference Source
located in photoreceptor outer segment IDA
IDA: Inferred from direct assay
11861639 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tyrosine-protein kinase Mer

Receptor tyrosine tinase gene probably the gene for Rdy

c-mer proto-oncogene tyrosine kinase

proto-oncogene c-Mer

proto-oncogene tyrosine-protein kinase MER

receptor tyrosine kinase MerTK

retinal dystrophy

Recombinant Mertk Proteins

Cat. No. Product Name Accession Purity
HY-P700594 MERTK Protein, Rat (HEK293, His) P57097 (G19-M497) ≥95%

Related Agents

Clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-15514 Merestinib Inhibitor 99.99% Phase 2
HY-101549 MRX-2843 Inhibitor 99.70% Phase 2
HY-15514A Merestinib dihydrochloride Inhibitor 99.36% Phase 2
Pre-clinical Phase
Bioactive Molecules (12)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12344 UNC2025 Inhibitor 99.83% Unkown
HY-125510 UNC2541 Inhibitor 99.71% Unkown
HY-12344A UNC2025 hydrochloride Inhibitor 99.87% Unkown
HY-132200 UNC5293 Inhibitor 99.93% Unkown
HY-117548 UNC1062 Inhibitor 99.48% Unkown
HY-124502 UNC4203 Inhibitor 99.80% Unkown
HY-131909 CJ-2360 Inhibitor / Unkown
HY-162406 UNC8969 / Unkown
HY-162940 MerTK/Axl-IN-1 Inhibitor / Unkown
HY-169208 MerTK-IN-1 Inhibitor / Unkown
HY-RS08340 MERTK Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-101549A MRX-2843 hydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mertk NCBI NCBI:10461
Macaca fascicularis Mertk NCBI NCBI:102143798
Mus musculus Mertk NCBI NCBI:17289