2. Gene
  3. Mfge8 - milk fat globule EGF and factor V/VIII domain containing Gene

Mfge8 - milk fat globule EGF and factor V/VIII domain containing Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as P47; MP47; Mfgm; SED1; MFG-E8; lactadherin

Gene ID: 17304 | Gene type: protein coding

About Mfge8

Summary

Enables Integrin binding activity; phosphatidylethanolamine binding activity; and phosphatidylserine binding activity. Involved in apoptotic cell clearance. Acts upstream of or within phagocytosis, engulfment; phagocytosis, recognition; and positive regulation of phagocytosis. Located in external side of plasma membrane and extracellular space. Is extrinsic component of plasma membrane. Is expressed in several structures, including alimentary system; cap mesenchyme; central nervous system; reproductive system; and sensory organ. Human ortholog(s) of this gene implicated in temporal arteritis. Orthologous to human MFGE8 (milk fat globule EGF and factor V/VIII domain containing). [provided by Alliance of Genome Resources, Apr 2022]

Mfge8 Products(2)

mRNA Protein Name
NM_001045489.1 NP_001038954.1 lactadherin isoform 2 precursor
NM_008594.2 NP_032620.2 lactadherin isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables integrin binding IDA
IDA: Inferred from direct assay
20826760 MGI
Biological Process GO Annotation Evidence Reference Source
involved in apoptotic cell clearance IDA
IDA: Inferred from direct assay
20826760 MGI
Cellular Component GO Annotation Evidence Reference Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
12000961 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
12000961 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lactadherin

EGF/factor VIII

milk fat globule glycoprotein

milk fat globule-EGF factor 8 protein

sperm surface protein SP47

Recombinant Mfge8 Proteins

Cat. No. Product Name Accession Purity
HY-P77749 MFG-E8 Protein, Mouse (HEK293, His) P21956 (A23-C463) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08381 MFGE8 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mfge8 NCBI NCBI:4240